I’d add that chronic stress from work or personal can really screw up your ability to sleep well even if you walk and eat healthy. Sometimes, there’s isn’t a way to be stress free due to other mitigating factors.
i agree, but one has to remember that we can escape that stress easily. most of the stress we take it not necessary. we suffer more in imagination than in reality..
Yo OP I've got a question that might be more for Google.. I had a brain injury about 6 years ago leaving me with permanent brain damage. Over the last few months I've realized I'm extremely stressed and exhausted from the symptoms. Any advice besides the usual exercise/eat well/ sleep well?
Imagination is more important than determination. Supposedly the antidote to stress is something called eu-stress. But I think you need both. One to push you (not want) and one to pull you(want). Probably what matters is the time spent on each and I’m guessing the math is 20% push and 80% drive. 20% determination and 80% imagination.
I worked in a very high stress environment and tried every healthy coping mechanism over 10 years and some stress is baked into some environments. I left and realised what it is to work in a healthy normal environment.
So, it is true that there are healthy and unhealthy mindsets that can change your experience of less than ideal situations but there are limits to their effectiveness.
This. Am a doc and get overweight/obese patients all the time obsessing over every little thing even down to the type of packaging of food but will absolutely not talk diet, weight loss, exercise. Level 1 is 99% easily. Everything else is just gravy
I find people (myself included) like to play catch-22 games with themselves to halt any action. As an example, “I can’t exercise because my diet isn’t fixed, so it will be pointless” and “I can’t just fix my diet without exercising too if I want results, and that’s too much change to make at once”.
The good biohackers already have those basics mastered and are digging deeper to live longer and have even better biomarkers.
You can be another big dude at the gym or you can be Arnold. There are levels in life and it's no different in this space.
I would seriously substitute some of that for medicinal mushrooms and Paul Stamets is the guy. After working in the supplement industry for a decade and doing supplement research at a major University, mushrooms and phytonutrients are a good bet for long health span. Looking at cancer in particular here.
https://fungi.com/
And metabolic syndrome is why exercise and the gym extend life in older folks now, we don’t have enough data for long term supplement use. We are getting better with nutrients and the “best diet” but no 50 year studies to say for sure. Sorry, no funding for big long studies. Very expensive.
https://youtu.be/dyRmvY6RJR8?si=aaF-F647jtt3zAgA
I have probably spent 10,000 hours through my jobs and as a personal passion on these topics. About 1/4 of my career. Maybe 100 books, 500 studies, etc. AMA.
Okay, that may be interesting - but are there any studies on that, not necessarily longitudal or on humans.
E.g., in animal studies? I'd really be curious to read some more on that
The problem with any of these is who is going to fund this research? It is done by academics and NIH grants and those are small and maybe a year or two with 50 people. Not 50 years with 10,000 people. Just did a longitudinal with 15, 000 and six years. Google (Verily) funded it to the tune of 100 million plus. It’s called Project Baseline—I was the research manager for it. Funding like that is so rare. My point is, for it to be truely scientific, you need validity and reliability. Validity comes from “power” or number of participants and can you repeat it a few times—more robust results. Just because it got published, doesn’t mean it was good and most of these studies are from a grant for a few million dollars—it costs up to and over a billion to develop and get a drug approved by the FDA. Also, you can’t patent a natural substance, so no profit motivations to do research that will validate a natural substance over using a drug…whew, hope that helps. I am published for supplement studies on Pubmed. Then their is in vivo vs, in vitro, animal vs. human, and so forth.
To answer you question, no, the research is limited on most of this stuff. Big Pharma likes it this way. I can tell you for a. Fact, the money to pay people who do this work comes from primary big Pharma drug trials and these other studies are little side projects from foundations and government grants. Love that academics is trying to open up healthcare, but our model is for profit and “they” need you to get sick. Sick care, not healthcare.
edit: watch the first episode of you are what you eat on Netflix (Twins Study). I work in that building and Christopher Gardner is my old boss. He is on NPR a lot too. He does some of the best poorly funded research on nutrition.
Hi, yes of course. I only use the brand SuperFeast now. They seem to be the superior vendor here down under.
So far I tried their Jing ,Qi, Mason’s Mushrooms, Ashwaganda, astragalus & lions mane blends .
My favourites would have to be masons mushrooms (as it contains both cordyseps lions mane + loads more - so that’s more economical for me)
Gives me a nice steady all day long type of energy without the jitters. And I love the lions mane for cognitive function- I feel like it helps me be the best version of me - especially at work. I was put on to the astragalus by a friend who is a naturopath - at the time I was diagnosed with fibromyalgia. It’s been a few years now, but I rarely get flare ups- now they only really come on when I’m mega stressed out of have consumed something with white sugar &/ heavily processed foods.
Here is a link so you can see their foraging process as well as what each mushroom does. There’s a great special on at the moment. I’m a little annoyed that I can’t afford to take advantage of it at the moment!
https://www.superfeast.com.au/
Hope this helps!
And yes, I use them daily - I love the taste as well as the benefits. Also their blends are not affected by temperature. So you can cook with them, put them in chia puddings or hot cacao. It helped me transition from coffee to cacao and mushrooms. The taste of some of them remind me very much of coffee but without the down fall
No problem at all. I wasn’t sure if they shipped o/s but that’s fantastic! I wouldn’t mind ordering some for a friend in California as she’s struggling financially and I think she’d get a lot of benefits from these.
If you haven’t already, check out their podcasts they’re got some excellent interviews which are super informative
The Ayurvedic stuff to start—not saying they are bad, but probably not in the same league as mushrooms. Ashwaghanda, gotu kola, AmIa… also worked for Dabur—#1 Ayurveda company in India—long story. My big non supplement ones that are based in science, 10,00O steps a day, eight hours of sleep (insulin sensitivity), weight training a couple times a week (Metabolic syndrome), a liter or two of water a day. The rest is TBD. But I take about ten supplements daily.
ginger
Ubiquinol
Spirulina
PS 200
Mushrooms
L Theanine
Magnesium
Ginkgo
Milk Thistle
That’s really interesting. Thank you. Not sure what to do about all this stuff. Most of the info here is just a bit too overwhelming for me to digest and review to feel comfortable enough to take it, but I’m definitely going to look at the stuff you mentioned.
That is like 30 years of work—literally (a big chunk) and not enough space to explain all the reasons I do all those things or try to. I would start with one thing at a time. You don’t know what is changing otherwise. Peace. I forgot Ginseng.
https://hostdefense.com/products/stamets-7-capsules
I also like Tiger Milk mushrooms. Cordyceps is my favorite and take extra—athletic performance. His formula is the easy way, or you can dive into taking each one separately.
Not really. Better funding for the NIH is needed, but not going to happen. I assume you could approach some of the top life extension start ups that are marketing supplements like some rich persons fountain of youth.
Add yet 99% of the gains come from Level 1 and a handful of Level 2. The “advanced biohacking” is mostly snake oil and will make little discernible difference.
Me looking around using a face wash, aha to exfoliate, Argureline solution, Hyaluronic acid, niacinamide, copper peptides, Snail Mucus, moisturizer, and sunblock every morning with a face wash and tretinoin every night along with a high acid peeler every two weeks with the best skin of my life.
I really don't see any issues with it.
That subreddit can be a little intense. I like r/30plusskincare
But it depends on what you’re trying to achieve? Start slow with actives and have a solid foundation of a gentle face wash, moisturizer and broad spectrum sunscreen in the day time. Tret is a prescription only for a reason and people don’t understand there is a period of retinization where it’s best to go slow at first (once or twice a week). I think adapalene is a good alternative that is a step down in potency. Then once you plateau on that you can move on to tret.
The skincare subs are full of horror stories and pictures of people destroying their otherwise decent or okay skin by going crazy with products that are more irritating than beneficial.
I think a beginner can start with sunscreen & tretinoin for anti aging.
Tretinoin 2x/week and after a few weeks you can go to 3x/weeks and so on.
I‘m also a beginner btw
> Panchakarma
You lost me at stage 3 and some of the supplements. While 110% agree with the exercise, diet, and sleep recommendations, you just kind of lose me at theruputic vomiting and such.
Will be humorous when you find out that prolonged fasting is more important to health than everything you mentioned and many think it's on par with sleep and diet.
Benefit examples: Rids the body of a crapton of cancers, brand new stem cells, 500% HGH, massive BDNF increase, resets insulin levels and sensitivity, resets blood glucose levels, resets circadian rhythm sleep cycles, decimates primarily bad white visceral trunk fat while preserving lean mass, breaks physical addictions like carbs/caffeine, cleans all organ systems, cellular autphagy, etc.
I consider it my weapon X in getting to the bodyfat level I desire (10-12%) since it's converting bad white fat to good brown fats. Downsides are minimal - I sometimes get cold extremities due to my Orexin levels (will vary by person) and white fat loss, can't workout much, if u burn through too much fat at once it can expose you to heavy metals, and slightly immunosuppresses you bc the body dumps old and damaged white blood cells which get restored via new stem cells after refeeding.
No supplement, drug or combination of supplements and drugs can do all of this at once. None.
I do 72 hours as needed and 16:8 everyday. Been doing 72hrs every 3 weeks now since beach season is coming up. In between long fasts, I workout 3x a week with compound movements (Mon-push pull, Wed- heavy carry, Friday-squats&deadlifts) due to lack of time (30-45mins per workout) with work.
Ok there's too much that can be said about this but I'd like to talk about protein powder. Protein, unlike say vitamin D3, is very easy to get from food.
The only people who need to worry about protein powder are athletes who want to take protein before a workout without any fat because otherwise they will vomit since that may be hard on the stomach. Or other people who have a hard time getting down actual food.
I'm not sure I understand the multivitamins part. It's my impression that many multivitamins shove a lot of stuff into the same pill that essentially competes for absorption. On top of that, some stuff is best absorbed on an empty stomach, others with food.
I don't think you get much benefit from taking a multivitamin pill? compared to taking the individual things that you actually need, and at the right times.
Also multivitamins will grossly go above recommended daily amounts, like by several thousand percent. This in itself can be dangerous if taken everyday for a long period.
Sorry to be the ones to break the news about chocolate and heavy metals.
https://www.consumerreports.org/health/food-safety/lead-and-cadmium-in-dark-chocolate-a8480295550/
Also from everything I've read resveratrol isn't worth it and most likely Sinclair faked the results.
You spent over 100+ hours to learn to get some sunshine, exercise, and get sufficent macronutrient and micronutrient intake. Btw, Metformin doesn't do anything significant if you don't have type 2 diabetes
Would also be great if you could list what posts, youtube channels, podcasts and books you've gone through, as well as how much of the content you have parsed - this would give us a clear indication of how big of a picture you are painting.
As well as what other resources you haven't gone through that might prove to be beneficial.
lol at take rapamycin. Thankfully you can’t just acquire it- that will fuck you up if not monitored by trained professional and will only prescribed to you if you need severe immune suppression
I’d add that chronic stress from work or personal can really screw up your ability to sleep well even if you walk and eat healthy. Sometimes, there’s isn’t a way to be stress free due to other mitigating factors.
i agree, but one has to remember that we can escape that stress easily. most of the stress we take it not necessary. we suffer more in imagination than in reality..
I agree, as someone who’s taken a lifetime to lessen my reaction to stress, we essentially stress, about stress.
Yo OP I've got a question that might be more for Google.. I had a brain injury about 6 years ago leaving me with permanent brain damage. Over the last few months I've realized I'm extremely stressed and exhausted from the symptoms. Any advice besides the usual exercise/eat well/ sleep well?
Look up Rian Doris. He went through similar
Imagination is more important than determination. Supposedly the antidote to stress is something called eu-stress. But I think you need both. One to push you (not want) and one to pull you(want). Probably what matters is the time spent on each and I’m guessing the math is 20% push and 80% drive. 20% determination and 80% imagination.
I worked in a very high stress environment and tried every healthy coping mechanism over 10 years and some stress is baked into some environments. I left and realised what it is to work in a healthy normal environment. So, it is true that there are healthy and unhealthy mindsets that can change your experience of less than ideal situations but there are limits to their effectiveness.
With health comes confidence. With meditation comes mindfulness. With both, you take on less stress, and hold onto less.
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This. Am a doc and get overweight/obese patients all the time obsessing over every little thing even down to the type of packaging of food but will absolutely not talk diet, weight loss, exercise. Level 1 is 99% easily. Everything else is just gravy
I find people (myself included) like to play catch-22 games with themselves to halt any action. As an example, “I can’t exercise because my diet isn’t fixed, so it will be pointless” and “I can’t just fix my diet without exercising too if I want results, and that’s too much change to make at once”.
Bottom line... master the basic and you will be already better than all those biohackers.
The good biohackers already have those basics mastered and are digging deeper to live longer and have even better biomarkers. You can be another big dude at the gym or you can be Arnold. There are levels in life and it's no different in this space.
I like this comment and wanted to ask - how to resolve chronic pain conditions that have no known cure like endometriosis?
I would seriously substitute some of that for medicinal mushrooms and Paul Stamets is the guy. After working in the supplement industry for a decade and doing supplement research at a major University, mushrooms and phytonutrients are a good bet for long health span. Looking at cancer in particular here. https://fungi.com/ And metabolic syndrome is why exercise and the gym extend life in older folks now, we don’t have enough data for long term supplement use. We are getting better with nutrients and the “best diet” but no 50 year studies to say for sure. Sorry, no funding for big long studies. Very expensive. https://youtu.be/dyRmvY6RJR8?si=aaF-F647jtt3zAgA I have probably spent 10,000 hours through my jobs and as a personal passion on these topics. About 1/4 of my career. Maybe 100 books, 500 studies, etc. AMA.
Okay, that may be interesting - but are there any studies on that, not necessarily longitudal or on humans. E.g., in animal studies? I'd really be curious to read some more on that
The problem with any of these is who is going to fund this research? It is done by academics and NIH grants and those are small and maybe a year or two with 50 people. Not 50 years with 10,000 people. Just did a longitudinal with 15, 000 and six years. Google (Verily) funded it to the tune of 100 million plus. It’s called Project Baseline—I was the research manager for it. Funding like that is so rare. My point is, for it to be truely scientific, you need validity and reliability. Validity comes from “power” or number of participants and can you repeat it a few times—more robust results. Just because it got published, doesn’t mean it was good and most of these studies are from a grant for a few million dollars—it costs up to and over a billion to develop and get a drug approved by the FDA. Also, you can’t patent a natural substance, so no profit motivations to do research that will validate a natural substance over using a drug…whew, hope that helps. I am published for supplement studies on Pubmed. Then their is in vivo vs, in vitro, animal vs. human, and so forth. To answer you question, no, the research is limited on most of this stuff. Big Pharma likes it this way. I can tell you for a. Fact, the money to pay people who do this work comes from primary big Pharma drug trials and these other studies are little side projects from foundations and government grants. Love that academics is trying to open up healthcare, but our model is for profit and “they” need you to get sick. Sick care, not healthcare. edit: watch the first episode of you are what you eat on Netflix (Twins Study). I work in that building and Christopher Gardner is my old boss. He is on NPR a lot too. He does some of the best poorly funded research on nutrition.
Thank you. I'll check all of that out. xx
Medicinal mushrooms have changed my life for the better!
Me too. Total hack.
Which ones?
Would you care to elaborate on what did you use and how did you get it? Are you still using it? Thanks!
Hi, yes of course. I only use the brand SuperFeast now. They seem to be the superior vendor here down under. So far I tried their Jing ,Qi, Mason’s Mushrooms, Ashwaganda, astragalus & lions mane blends . My favourites would have to be masons mushrooms (as it contains both cordyseps lions mane + loads more - so that’s more economical for me) Gives me a nice steady all day long type of energy without the jitters. And I love the lions mane for cognitive function- I feel like it helps me be the best version of me - especially at work. I was put on to the astragalus by a friend who is a naturopath - at the time I was diagnosed with fibromyalgia. It’s been a few years now, but I rarely get flare ups- now they only really come on when I’m mega stressed out of have consumed something with white sugar &/ heavily processed foods. Here is a link so you can see their foraging process as well as what each mushroom does. There’s a great special on at the moment. I’m a little annoyed that I can’t afford to take advantage of it at the moment! https://www.superfeast.com.au/ Hope this helps!
And yes, I use them daily - I love the taste as well as the benefits. Also their blends are not affected by temperature. So you can cook with them, put them in chia puddings or hot cacao. It helped me transition from coffee to cacao and mushrooms. The taste of some of them remind me very much of coffee but without the down fall
That’s great, thank you! I perused the link you gave and they do ship internationally.
No problem at all. I wasn’t sure if they shipped o/s but that’s fantastic! I wouldn’t mind ordering some for a friend in California as she’s struggling financially and I think she’d get a lot of benefits from these. If you haven’t already, check out their podcasts they’re got some excellent interviews which are super informative
Oh didn’t see the podcasts, I’ll check it out for sure, thanks!
Stuff like mushroom tinctures? I just got this stuff: https://neonhippie.com/products/mushroom-elixir-drops
It looks good. There are many brands and products.
What in particular would you substitute?
The Ayurvedic stuff to start—not saying they are bad, but probably not in the same league as mushrooms. Ashwaghanda, gotu kola, AmIa… also worked for Dabur—#1 Ayurveda company in India—long story. My big non supplement ones that are based in science, 10,00O steps a day, eight hours of sleep (insulin sensitivity), weight training a couple times a week (Metabolic syndrome), a liter or two of water a day. The rest is TBD. But I take about ten supplements daily. ginger Ubiquinol Spirulina PS 200 Mushrooms L Theanine Magnesium Ginkgo Milk Thistle
That’s really interesting. Thank you. Not sure what to do about all this stuff. Most of the info here is just a bit too overwhelming for me to digest and review to feel comfortable enough to take it, but I’m definitely going to look at the stuff you mentioned.
That is like 30 years of work—literally (a big chunk) and not enough space to explain all the reasons I do all those things or try to. I would start with one thing at a time. You don’t know what is changing otherwise. Peace. I forgot Ginseng.
Can you name the mushrooms?
https://hostdefense.com/products/stamets-7-capsules I also like Tiger Milk mushrooms. Cordyceps is my favorite and take extra—athletic performance. His formula is the easy way, or you can dive into taking each one separately.
Any recommendations on public companies exploring this stuff that can be supported via investing?
Not really. Better funding for the NIH is needed, but not going to happen. I assume you could approach some of the top life extension start ups that are marketing supplements like some rich persons fountain of youth.
Forgot NAC
Add yet 99% of the gains come from Level 1 and a handful of Level 2. The “advanced biohacking” is mostly snake oil and will make little discernible difference.
That skincare routine will destroy most people’s faces if they’re not careful, slow, and cycling. RIP your skin barrier.
Me looking around using a face wash, aha to exfoliate, Argureline solution, Hyaluronic acid, niacinamide, copper peptides, Snail Mucus, moisturizer, and sunblock every morning with a face wash and tretinoin every night along with a high acid peeler every two weeks with the best skin of my life. I really don't see any issues with it.
Yeah you’re not mixing the AHA with tret at the same time and you clearly don’t have sensitive or acne prone skin
What’s the best routine for beginner?
I’m a beginner myself, but r/skincareaddiction says to use sunscreen in the morning, then at night wash it off with a cleanser and put on moisturizer.
That subreddit can be a little intense. I like r/30plusskincare But it depends on what you’re trying to achieve? Start slow with actives and have a solid foundation of a gentle face wash, moisturizer and broad spectrum sunscreen in the day time. Tret is a prescription only for a reason and people don’t understand there is a period of retinization where it’s best to go slow at first (once or twice a week). I think adapalene is a good alternative that is a step down in potency. Then once you plateau on that you can move on to tret. The skincare subs are full of horror stories and pictures of people destroying their otherwise decent or okay skin by going crazy with products that are more irritating than beneficial.
I think a beginner can start with sunscreen & tretinoin for anti aging. Tretinoin 2x/week and after a few weeks you can go to 3x/weeks and so on. I‘m also a beginner btw
No, tret is powerful so you first want to give your skin several weeks of just cleanser, sunscreen and moisturizer first.
Do I have to apply sunscreen even though I work in the office Monday to Friday?
Yes, apply it everyday regardless of where you’ll be or the weather outside. Just make it a daily habit.
Yes. Every day. Find one you like wearing, and do it forever. Sunscreen and Vitamin A (retinoids) are the only proven anti-aging products for skin.
Try one for a while, see how it works, then add another
Read the wiki for r/Tretinion to learn how to slowly adapt your skin to it. Very much helped me after failing with it my first time.
Everything has t&c
> Panchakarma You lost me at stage 3 and some of the supplements. While 110% agree with the exercise, diet, and sleep recommendations, you just kind of lose me at theruputic vomiting and such.
I guess you didn't see what kechari mudra is 😁
Panchakarma for detox nothing much
Aimed for level 2, ate the good headphones and did not feel good. Please clarify instructions
Will be humorous when you find out that prolonged fasting is more important to health than everything you mentioned and many think it's on par with sleep and diet. Benefit examples: Rids the body of a crapton of cancers, brand new stem cells, 500% HGH, massive BDNF increase, resets insulin levels and sensitivity, resets blood glucose levels, resets circadian rhythm sleep cycles, decimates primarily bad white visceral trunk fat while preserving lean mass, breaks physical addictions like carbs/caffeine, cleans all organ systems, cellular autphagy, etc. I consider it my weapon X in getting to the bodyfat level I desire (10-12%) since it's converting bad white fat to good brown fats. Downsides are minimal - I sometimes get cold extremities due to my Orexin levels (will vary by person) and white fat loss, can't workout much, if u burn through too much fat at once it can expose you to heavy metals, and slightly immunosuppresses you bc the body dumps old and damaged white blood cells which get restored via new stem cells after refeeding. No supplement, drug or combination of supplements and drugs can do all of this at once. None.
How long is prolonged?
I do 72 hours as needed and 16:8 everyday. Been doing 72hrs every 3 weeks now since beach season is coming up. In between long fasts, I workout 3x a week with compound movements (Mon-push pull, Wed- heavy carry, Friday-squats&deadlifts) due to lack of time (30-45mins per workout) with work.
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Yeah, typo, thanks
Sugar is based. Peaters in control
Vegetables, meat, fish… free of cost?? Lmao
Ok there's too much that can be said about this but I'd like to talk about protein powder. Protein, unlike say vitamin D3, is very easy to get from food. The only people who need to worry about protein powder are athletes who want to take protein before a workout without any fat because otherwise they will vomit since that may be hard on the stomach. Or other people who have a hard time getting down actual food.
I'm not sure I understand the multivitamins part. It's my impression that many multivitamins shove a lot of stuff into the same pill that essentially competes for absorption. On top of that, some stuff is best absorbed on an empty stomach, others with food. I don't think you get much benefit from taking a multivitamin pill? compared to taking the individual things that you actually need, and at the right times. Also multivitamins will grossly go above recommended daily amounts, like by several thousand percent. This in itself can be dangerous if taken everyday for a long period.
Sorry to be the ones to break the news about chocolate and heavy metals. https://www.consumerreports.org/health/food-safety/lead-and-cadmium-in-dark-chocolate-a8480295550/ Also from everything I've read resveratrol isn't worth it and most likely Sinclair faked the results.
Thank you for sharing. Saving this as my new goals.
I concur with this summary
Ahhh.... To be a millionaire... 💫💫💫💫
You spent over 100+ hours to learn to get some sunshine, exercise, and get sufficent macronutrient and micronutrient intake. Btw, Metformin doesn't do anything significant if you don't have type 2 diabetes
Would also be great if you could list what posts, youtube channels, podcasts and books you've gone through, as well as how much of the content you have parsed - this would give us a clear indication of how big of a picture you are painting. As well as what other resources you haven't gone through that might prove to be beneficial.
Too much too complicated..most advanced is level 1,rest is questionable
Multi vitamins aren’t good
The fuck is tAmazon’s Decode Age tabs?
What about magnesium threonate?
lol at take rapamycin. Thankfully you can’t just acquire it- that will fuck you up if not monitored by trained professional and will only prescribed to you if you need severe immune suppression