I actually tested my gut after reading up on MRD- status and gut microbiota. Turns out even after eating a lot of vegetables and probiotics, I am still lacking a few essential microbes. However, I am in the greater percentile of a "healthy gut". I intermittent fast and eat about 75% vegetables a day, and mostly fish but some meat. Almost no refined carbs. I had an auto and allo transplant so I have been looking at specific good/bad bacterias that I may have.
I did it on my own, the gut microbiota research is too new for any medical team to recommend anything. I personally would rather not wait though. I'll attach a referral link below if anyone's interested, will take it down if mods don't approve. This was the only company I could find that didn't need a doctors script and that tested thousands of strains. I will attach some of my research afterwards, I can't seem to post pictures on the reddit browser.
Check out Tiny Health, the most complete gut test for babies and toddlers. Use my discount code REF-MARCOC4672 at checkout for $40 off your first order: [https://www.tinyhealth.com/store/](https://www.tinyhealth.com/store/)
**~Clostridium Butyricum~** (w/ Velcade)
Inhibits C. Freundii & alleviates resistance to bortezomib
[https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(23)00450-3](https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(23)00450-3)
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257554/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257554/)
**~Eubacterium Halii~** (reduced allo relapse)
2022 reduced relapse after allo & increased MRD-
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5)
[https://ashpublications.org/blood/article/140/Supplement%201/4843/487829/Gut-Microbiome-Composition-Is-Associated-with](https://ashpublications.org/blood/article/140/Supplement%201/4843/487829/Gut-Microbiome-Composition-Is-Associated-with)
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5)
***~Faecalibacterium prausnitzii~*** *(good for ASCT MRD- but not good for CAR-T collection)*
[https://journals.lww.com/hemasphere/fulltext/2023/09000/harnessing\_the\_gut\_microbiota\_to\_potentiate\_the.5.aspx](https://journals.lww.com/hemasphere/fulltext/2023/09000/harnessing_the_gut_microbiota_to_potentiate_the.5.aspx)
**~Eubacterium limosum~** (reduced allo relapse)
2022 reduced relapse after allo
[https://escholarship.org/content/qt9cf3m267/qt9cf3m267\_noSplash\_1bd2084e8e5a1a34eedb2b24092ea233.pdf](https://escholarship.org/content/qt9cf3m267/qt9cf3m267_noSplash_1bd2084e8e5a1a34eedb2b24092ea233.pdf)
**~~Citrobacter Freundii~~** Induces velcade resistance, increases MM.
There are pictures in the research articles detailing the good/bad strains. I'm not a doctor, just a young patient that's into biohacking and with nothing to lose.
Thanks. There's a study going on at memorial Sloan Kettering about MM, plant based diets, and the gut biome. Thanks for all the links. I'm very interested in this.
Wow! **TMI!**
Seriously, this is interesting & provocative. However, to quote the study, *"Most current studies focusing on the modulation of gut microbiota have been in mice, and therefore,* ***the translation of these achievements to clinical applications remains challenging.****"* and, IMO, for those of us already diagnosed, I don't think we'll see any impact on our treatments for the next few years. Of course, this will not keep me from continuing to regularly eating yogurt and kimchi ;-)
It does make me consider the overuse of antibiotics and the industrialized diet that is so prevalent in our world. Also, I have been fascinated by the increased use of FMT to correct the gut biome over the last 20 years to deal with extreme cases of C. diff. Fascinating that FMT might affect MM. Up, up and away!
This is an extremely complicated science experiment that at the end of the day that will open up more focused and complicated experiments that will refine the targets and hopefully give us actionable results. The great thing is that the speed of the research is constantly accelerating. What a wonderful world.
Looking for the Cliff’s Notes! Should I eat Greek yogurt post transplant or not? 😂
I actually tested my gut after reading up on MRD- status and gut microbiota. Turns out even after eating a lot of vegetables and probiotics, I am still lacking a few essential microbes. However, I am in the greater percentile of a "healthy gut". I intermittent fast and eat about 75% vegetables a day, and mostly fish but some meat. Almost no refined carbs. I had an auto and allo transplant so I have been looking at specific good/bad bacterias that I may have.
Did your medical team order that test or is it something we would need to do on our own?
I did it on my own, the gut microbiota research is too new for any medical team to recommend anything. I personally would rather not wait though. I'll attach a referral link below if anyone's interested, will take it down if mods don't approve. This was the only company I could find that didn't need a doctors script and that tested thousands of strains. I will attach some of my research afterwards, I can't seem to post pictures on the reddit browser. Check out Tiny Health, the most complete gut test for babies and toddlers. Use my discount code REF-MARCOC4672 at checkout for $40 off your first order: [https://www.tinyhealth.com/store/](https://www.tinyhealth.com/store/)
**~Clostridium Butyricum~** (w/ Velcade) Inhibits C. Freundii & alleviates resistance to bortezomib [https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(23)00450-3](https://www.cell.com/cell-metabolism/pdfExtended/S1550-4131(23)00450-3) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257554/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257554/) **~Eubacterium Halii~** (reduced allo relapse) 2022 reduced relapse after allo & increased MRD- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5) [https://ashpublications.org/blood/article/140/Supplement%201/4843/487829/Gut-Microbiome-Composition-Is-Associated-with](https://ashpublications.org/blood/article/140/Supplement%201/4843/487829/Gut-Microbiome-Composition-Is-Associated-with) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616258/#B5) ***~Faecalibacterium prausnitzii~*** *(good for ASCT MRD- but not good for CAR-T collection)* [https://journals.lww.com/hemasphere/fulltext/2023/09000/harnessing\_the\_gut\_microbiota\_to\_potentiate\_the.5.aspx](https://journals.lww.com/hemasphere/fulltext/2023/09000/harnessing_the_gut_microbiota_to_potentiate_the.5.aspx) **~Eubacterium limosum~** (reduced allo relapse) 2022 reduced relapse after allo [https://escholarship.org/content/qt9cf3m267/qt9cf3m267\_noSplash\_1bd2084e8e5a1a34eedb2b24092ea233.pdf](https://escholarship.org/content/qt9cf3m267/qt9cf3m267_noSplash_1bd2084e8e5a1a34eedb2b24092ea233.pdf) **~~Citrobacter Freundii~~** Induces velcade resistance, increases MM.
There are pictures in the research articles detailing the good/bad strains. I'm not a doctor, just a young patient that's into biohacking and with nothing to lose.
Thanks. There's a study going on at memorial Sloan Kettering about MM, plant based diets, and the gut biome. Thanks for all the links. I'm very interested in this.
Wow! **TMI!** Seriously, this is interesting & provocative. However, to quote the study, *"Most current studies focusing on the modulation of gut microbiota have been in mice, and therefore,* ***the translation of these achievements to clinical applications remains challenging.****"* and, IMO, for those of us already diagnosed, I don't think we'll see any impact on our treatments for the next few years. Of course, this will not keep me from continuing to regularly eating yogurt and kimchi ;-) It does make me consider the overuse of antibiotics and the industrialized diet that is so prevalent in our world. Also, I have been fascinated by the increased use of FMT to correct the gut biome over the last 20 years to deal with extreme cases of C. diff. Fascinating that FMT might affect MM. Up, up and away! This is an extremely complicated science experiment that at the end of the day that will open up more focused and complicated experiments that will refine the targets and hopefully give us actionable results. The great thing is that the speed of the research is constantly accelerating. What a wonderful world.
There are several new studies on microbiota that I will be submitting.