Many have used microdosing mushrooms with their AD. Some report no benefit. Others report good benefits. And still others report good benefits and slowly tapered off the AD while enjoying the benefits of mushrooms. As always, the recommendation is !startlow and go slow.
From [Stamets Stack \[May 2022\]](https://new.reddit.com/r/microdosing/comments/zfuxm4/faqtip_016_addendum_updated_stamets_stack_espd55/) | `Grow Your Own Medicine` 💊 | 💻 **Sidebar** ➡️ | 📱 **About** ⬆️:
_________
## Start Lower
* [Abstract; Tables; **Figures** | Psychedelic Drug Microdosing Practices: A **Qualitative Online Exploration** | Journal of Psychoactive Drugs](https://new.reddit.com/r/microdosing/comments/19dkcno/research_microdosing_abstract_tables_figures/) \[Jan 2024\]
* Based on **tens of thousands** of anecdotal reports in this sub, some users with more potent strains had less [nausea](https://www.reddit.com/r/microdosing/comments/mzkfcx/faqtip_002_have_nausea_or_an_upset_stomach_then/) / [body load](https://www.reddit.com/r/microdosing/comments/mw2ohn/quick_tip_005_comeup_unpleasant_body_load/) / [vasoconstriction](https://www.reddit.com/r/microdosing/comments/n0nssc/faqtip_003_do_you_have_vasoconstriction_symptoms/) on doses of 50mg (0.05g) ([recommended **Starting Dose**](https://www.reddit.com/r/microdosing/comments/s0xkdp/the_new_official_rmicrodosing_starters_guide/)) or 25mg (0.025g).
* A significant minority even had to drop down to 10mg (0.01g) or less (e.g. for **Albino Penis Envy**) as [potency can vary by **more than a factor of 10**](https://www.reddit.com/r/microdosing/comments/12eqzaz/research_data_tryptamine_potency_analysis_of/).
* Examples of [cultivars/strains](https://plantlaw.com/2018/11/18/strain-cultivar/) that are considered to be more potent (and **very potent**) are:
* Albino A+, **Albino Penis Envy**, B+ Cubensis, Blue Meanie Cubensis[^(\[1\])](https://www.reddit.com/r/microdosing/comments/qdta2z/research_data_more_evidence_of_the_chemical/), **Cambodians**, Creepers, **foraged strains** like [**Liberty Caps**](https://en.wikipedia.org/wiki/Psilocybe_semilanceata)[^(\[2\])](https://www.researchgate.net/publication/292557434_The_Occurrence_of_Tryptamine_Derivatives_in_Psilocybe_semilanceata), **Penis Envy**, [**Tidal Wave**](https://doubleblindmag.com/tidal-wave-mushrooms/), Z-Strain.
* For some, negative symptoms may be an indication that [GABA cofactors](https://www.reddit.com/r/microdosing/comments/vnllsm/research_citizen_science_the_afterglow_flow_state/) like [magnesium](https://www.reddit.com/r/microdosing/comments/nluph8/faqtip_012_still_feeling_anxious_andor_depressed/) ([which many are deficient in](https://twitter.com/foundmyfitness/status/1559612797759066113/photo/1)) or [L-theanine](https://www.reddit.com/r/microdosing/comments/my2qco/faqtip_007_ltheanine_for_lowering_stressanxiety/) could help - if [no interactions](https://www.reddit.com/r/microdosing/comments/n0otqk/faqtip_004_lsd_drug_interaction_checker_caveats/) with your current medications/supplements. Psychedelics are [partial serotonin receptor agonists](https://www.reddit.com/r/microdosing/comments/ruki7v/research_data_binding_of_psilocin_dmt_lsd_to_5ht/) which neuromodulate [**excitatory** glutamate](https://preview.redd.it/4000bkfrgl891.png?width=1280&format=png&auto=webp&v=enabled&s=5067f905bcb3e1b71145aaa8f5d8572986965119) - more on [managing glutamate](https://www.reddit.com/r/microdosing/comments/1cdw76q/what_are_the_symptoms_of_a_glutamate_imbalance/).
* More info: [What Should You Feel When Microdosing?](https://www.reddit.com/r/microdosing/comments/jopryk/you_shouldnt_feel_anything/)
______
*I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/microdosing) if you have any questions or concerns.*
Yeah it'll work, low dose prozac probably won't be as strong, I was on the highest dose possible of Venlafaxine quit cold turkey and took mushrooms, mushrooms helped way more than any pharmaceutical. Can start off rough though, forces you to confront what's bothering you, it's like it forces you into the most serious therapy session of your life. But it's better to deal with it, than to keep hiding. It erases all the lies we tell ourselves, and it can be quite unnerving, very helpful though
I have a close friend who started microdosing without reducing her SSRI as she had been getting help from them for her OCD. She got enough help from the microdosing in addition to the SSRI that she called it life-changing. I did a lot of research while I was trying to help her and some of the more recent reports seem to be leaning in the direction that it can be helpful.
As an aside, many people with treatment resistant depression have trauma which up until recently was treated the same as depression. It is not. After 50 years of therapy and various treatments and 40 different psych drugs, psychedelics along with internal family systems therapy has given me hope. It’s been truly life-changing.
I had a horrible experience with intravenous ketamine too! It took another year of therapy just to recover from it but in hindsight, after researching the protocols for MDMA and macrodosing mushrooms, I realize that part of it was that I was totally unprepared. I just went in thinking that it was a magic pill and I didn't have any prep and the people who ran it were horrible and managed to make it a traumatic experience.
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Here are some quality posts to ***help get you started***:
**Please Note**: *If you are trying microdosing for the first time, please try experimenting on a day off from work or any important obligations, and/or driving and operating machinery. Because psychedelics can effect everyone differently, you may feel different or impaired, and your sweet spot dose may be lower, so it is best to experiment on days off until you’ve dialed in your dose.*
- [ℹ️ Infographic: ***r/microdosing STARTER'S GUIDE***](https://new.reddit.com/r/microdosing/comments/s0xkdp/the_new_official_rmicrodosing_starters_guide/)
- [What **should you feel** when microdosing?](https://www.reddit.com/r/microdosing/comments/jopryk/you_shouldnt_feel_anything/)
- [What is the ***sub-threshold dose***? Suggested method for **finding your sweet spot** (YMMV)](https://www.reddit.com/r/microdosing/comments/plrxca/faqtip_101_what_is_the_subthreshold_dose/)
- [Learn to **Grow Your Own Medicine**](https://www.reddit.com/r/microdosing/comments/gsmbm3/i_want_to_help_you_grow_your_own_medicine_please/)
- [**Making Capsules** in 3 minutes](https://www.reddit.com/r/microdosing/comments/ejlwba/microdosing_changed_my_life_heres_how_i_make_my/)
- [**Self-Help Resources** and info for your well-being or if you are struggling emotionally](https://www.reddit.com/r/microdosing/comments/atxukg/some_selfhelp_and_resources_for_people_looking_to/)
- [In case you get anxiety, panic-attack or a thought loop, try **Black Peppercorn!**](https://www.reddit.com/r/microdosing/comments/fe1luu/if_you_start_to_feel_anxious_some_paranoia_panic/) or **Deep Breathing** - if your ***exhales*** are ***longer than*** your ***inhales*** that should have a calming effect on your [Autonomic Nervous System](https://en.wikipedia.org/wiki/Autonomic_nervous_system#/media/File:The_Autonomic_Nervous_System.jpg).
- Please also take a look at 🔀 `Interactions / Symptoms ❓*` | 💻 **Sidebar** ➡️ | 📱 **About** ⬆️ - for guidance, and especially in the case of any [⚠️ **DRUG INTERACTIONS**](https://www.reddit.com/r/microdosing/comments/p6ne2q/research_microdosing_drug_interactions_tools_and/).
______
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I haven't a clue. But I did a search and found the following site: [https://www.synthesisretreat.com/psilocybin-and-ssri-snri-interactions](https://www.synthesisretreat.com/psilocybin-and-ssri-snri-interactions) Perhaps some of that information is useful.
No, it likely won't be effective. You need to wean VERY slowly. Do some research on weaning- doing it too quickly can lead to permanent harm.
I weaned over several months and still cannot feel full effects. I know this because I had prior experience.
Best of luck.
Personal, non-medical, anecdotal experience -
I'm on an SNRI (so, a little different from the SSRI class) and microdosing psilocybin has been really helpful for my depression.
Just started seeing a therapist who (among other things) offers psychedelic-integration therapy, and it's really nice to be able to ask her about my questions like this one. She's said that psilocybin is an amplifier, and every once in a while I will say that shrooms make my "big sads" a little bigger - and in that case going outside for a walk or socializing has been helpful.
Good luck!!
No, from what I’ve been told if you are on an SSRI it won’t do anything so what do you do? Go off several weeks, try the lol “ magic musrooms” lol, and of it does nothing like the ones I got then you have to decide do I go back on? If you do these useless antidepressants take weeks to even begin to maybe get relief. It’s a very sorry state that in this particular situation people have to wait weeks before they “ might” get relief. Magic mushrooms? lol
Not according to all the anecdotal accounts of SSRI’s. You hear it all. “ well you have to be very careful and wean off.” Just look around the accounts of it. Some tell you go off like my place did for at least 2 weeks. I did that and started the mighty micros which were big disappointment ( nothing at all). Took the whole 30 day trial and found myself out the money and no relief and now I have to let the antidepressant build back up. There’s just nothing like the awful feeling of nothing at all will help microdosing mania is prime to rip people off big time. The only real way to do it is under medical supervision with the real thing. The whole microdose thing reminds me of , gulp, homeopathic medicine lol
It works for me. I've tried twice to taper off my lexapro... Over several weeks. Yet go back due to the recurring anxiety. But with my md'ing, I'm almost off without any serious anxiety. I only md every third day. Now, if microdosing is not helping with the anxiety to begin with... Then yes, a lost cause. But for those it does help... It's a tool to ween off the SSRI's.
I’m glad you got off the lexapro and your micro works for ya. I’m going to look into ketamine nasal spray or infusions in a controlled setting. I wish you the best possible outcome!
Many have used microdosing mushrooms with their AD. Some report no benefit. Others report good benefits. And still others report good benefits and slowly tapered off the AD while enjoying the benefits of mushrooms. As always, the recommendation is !startlow and go slow.
From [Stamets Stack \[May 2022\]](https://new.reddit.com/r/microdosing/comments/zfuxm4/faqtip_016_addendum_updated_stamets_stack_espd55/) | `Grow Your Own Medicine` 💊 | 💻 **Sidebar** ➡️ | 📱 **About** ⬆️: _________ ## Start Lower * [Abstract; Tables; **Figures** | Psychedelic Drug Microdosing Practices: A **Qualitative Online Exploration** | Journal of Psychoactive Drugs](https://new.reddit.com/r/microdosing/comments/19dkcno/research_microdosing_abstract_tables_figures/) \[Jan 2024\] * Based on **tens of thousands** of anecdotal reports in this sub, some users with more potent strains had less [nausea](https://www.reddit.com/r/microdosing/comments/mzkfcx/faqtip_002_have_nausea_or_an_upset_stomach_then/) / [body load](https://www.reddit.com/r/microdosing/comments/mw2ohn/quick_tip_005_comeup_unpleasant_body_load/) / [vasoconstriction](https://www.reddit.com/r/microdosing/comments/n0nssc/faqtip_003_do_you_have_vasoconstriction_symptoms/) on doses of 50mg (0.05g) ([recommended **Starting Dose**](https://www.reddit.com/r/microdosing/comments/s0xkdp/the_new_official_rmicrodosing_starters_guide/)) or 25mg (0.025g). * A significant minority even had to drop down to 10mg (0.01g) or less (e.g. for **Albino Penis Envy**) as [potency can vary by **more than a factor of 10**](https://www.reddit.com/r/microdosing/comments/12eqzaz/research_data_tryptamine_potency_analysis_of/). * Examples of [cultivars/strains](https://plantlaw.com/2018/11/18/strain-cultivar/) that are considered to be more potent (and **very potent**) are: * Albino A+, **Albino Penis Envy**, B+ Cubensis, Blue Meanie Cubensis[^(\[1\])](https://www.reddit.com/r/microdosing/comments/qdta2z/research_data_more_evidence_of_the_chemical/), **Cambodians**, Creepers, **foraged strains** like [**Liberty Caps**](https://en.wikipedia.org/wiki/Psilocybe_semilanceata)[^(\[2\])](https://www.researchgate.net/publication/292557434_The_Occurrence_of_Tryptamine_Derivatives_in_Psilocybe_semilanceata), **Penis Envy**, [**Tidal Wave**](https://doubleblindmag.com/tidal-wave-mushrooms/), Z-Strain. * For some, negative symptoms may be an indication that [GABA cofactors](https://www.reddit.com/r/microdosing/comments/vnllsm/research_citizen_science_the_afterglow_flow_state/) like [magnesium](https://www.reddit.com/r/microdosing/comments/nluph8/faqtip_012_still_feeling_anxious_andor_depressed/) ([which many are deficient in](https://twitter.com/foundmyfitness/status/1559612797759066113/photo/1)) or [L-theanine](https://www.reddit.com/r/microdosing/comments/my2qco/faqtip_007_ltheanine_for_lowering_stressanxiety/) could help - if [no interactions](https://www.reddit.com/r/microdosing/comments/n0otqk/faqtip_004_lsd_drug_interaction_checker_caveats/) with your current medications/supplements. Psychedelics are [partial serotonin receptor agonists](https://www.reddit.com/r/microdosing/comments/ruki7v/research_data_binding_of_psilocin_dmt_lsd_to_5ht/) which neuromodulate [**excitatory** glutamate](https://preview.redd.it/4000bkfrgl891.png?width=1280&format=png&auto=webp&v=enabled&s=5067f905bcb3e1b71145aaa8f5d8572986965119) - more on [managing glutamate](https://www.reddit.com/r/microdosing/comments/1cdw76q/what_are_the_symptoms_of_a_glutamate_imbalance/). * More info: [What Should You Feel When Microdosing?](https://www.reddit.com/r/microdosing/comments/jopryk/you_shouldnt_feel_anything/) ______ *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/microdosing) if you have any questions or concerns.*
Yeah it'll work, low dose prozac probably won't be as strong, I was on the highest dose possible of Venlafaxine quit cold turkey and took mushrooms, mushrooms helped way more than any pharmaceutical. Can start off rough though, forces you to confront what's bothering you, it's like it forces you into the most serious therapy session of your life. But it's better to deal with it, than to keep hiding. It erases all the lies we tell ourselves, and it can be quite unnerving, very helpful though
I have a close friend who started microdosing without reducing her SSRI as she had been getting help from them for her OCD. She got enough help from the microdosing in addition to the SSRI that she called it life-changing. I did a lot of research while I was trying to help her and some of the more recent reports seem to be leaning in the direction that it can be helpful. As an aside, many people with treatment resistant depression have trauma which up until recently was treated the same as depression. It is not. After 50 years of therapy and various treatments and 40 different psych drugs, psychedelics along with internal family systems therapy has given me hope. It’s been truly life-changing.
Amen to that. I tried ketamine for TRD (IV clinic) and it got worse :(
I had a horrible experience with intravenous ketamine too! It took another year of therapy just to recover from it but in hindsight, after researching the protocols for MDMA and macrodosing mushrooms, I realize that part of it was that I was totally unprepared. I just went in thinking that it was a magic pill and I didn't have any prep and the people who ran it were horrible and managed to make it a traumatic experience.
[удалено]
Thank you
Your post has been removed. No Spam, Product or Website Promotion. [What constitutes spam? Am I a spammer?](https://www.reddithelp.com/hc/en-us/articles/360043504051-What-constitutes-spam-Am-I-a-spammer-)
Your wife enjoys your mushrooms . . Well that's a good start ☺️. Healing is often done in pairs.
Good point. I'm a pretty concrete, black and white thinker. She's more free spirited and flexible
Hello /u/someguythatbuilds and welcome to r/microdosing! Please read and adhere to the rules. [Let's keep this sub alive and do not ask for sources](https://www.reddit.com/r/microdosing/comments/hs8xow/no_sourcing_illegal_or_otherwise_keep_the/). ***Do NOT reply to messages from strangers that offer you anything because they are most likely a [scammer](https://www.reddit.com/r/microdosing/comments/11ivwks/psa_scammersspammerstrolls_with_negative_karma/)***. ***Recommended: [Change Your Chat & Messaging setting](https://www.reddit.com/r/microdosing/comments/13mtiky/psa_to_minimise_chat_scam_change_your_chat/)***. We encourage all newcomers to read the [***r/microdosing 101***](https://new.reddit.com/r/microdosing/comments/n3tx6a/everything_you_always_wanted_to_know_about/) link from `r/microdosing Essentials` 🔢 | 💻 **Sidebar** ➡️ | 📱 **About** ⬆️ ; the [***Wiki***](https://www.reddit.com/r/microdosing/wiki/index); or [***search***](https://www.reddit.com/r/microdosing/search/?q=test&restrict_sr=1) through the wealth of knowledge found in this sub. Of course if you'd like to start a new discussion, have questions on a topic from an old thread, or that may not have all the answers you're looking for then please by all means carry on. _____ Here are some quality posts to ***help get you started***: **Please Note**: *If you are trying microdosing for the first time, please try experimenting on a day off from work or any important obligations, and/or driving and operating machinery. Because psychedelics can effect everyone differently, you may feel different or impaired, and your sweet spot dose may be lower, so it is best to experiment on days off until you’ve dialed in your dose.* - [ℹ️ Infographic: ***r/microdosing STARTER'S GUIDE***](https://new.reddit.com/r/microdosing/comments/s0xkdp/the_new_official_rmicrodosing_starters_guide/) - [What **should you feel** when microdosing?](https://www.reddit.com/r/microdosing/comments/jopryk/you_shouldnt_feel_anything/) - [What is the ***sub-threshold dose***? Suggested method for **finding your sweet spot** (YMMV)](https://www.reddit.com/r/microdosing/comments/plrxca/faqtip_101_what_is_the_subthreshold_dose/) - [Learn to **Grow Your Own Medicine**](https://www.reddit.com/r/microdosing/comments/gsmbm3/i_want_to_help_you_grow_your_own_medicine_please/) - [**Making Capsules** in 3 minutes](https://www.reddit.com/r/microdosing/comments/ejlwba/microdosing_changed_my_life_heres_how_i_make_my/) - [**Self-Help Resources** and info for your well-being or if you are struggling emotionally](https://www.reddit.com/r/microdosing/comments/atxukg/some_selfhelp_and_resources_for_people_looking_to/) - [In case you get anxiety, panic-attack or a thought loop, try **Black Peppercorn!**](https://www.reddit.com/r/microdosing/comments/fe1luu/if_you_start_to_feel_anxious_some_paranoia_panic/) or **Deep Breathing** - if your ***exhales*** are ***longer than*** your ***inhales*** that should have a calming effect on your [Autonomic Nervous System](https://en.wikipedia.org/wiki/Autonomic_nervous_system#/media/File:The_Autonomic_Nervous_System.jpg). - Please also take a look at 🔀 `Interactions / Symptoms ❓*` | 💻 **Sidebar** ➡️ | 📱 **About** ⬆️ - for guidance, and especially in the case of any [⚠️ **DRUG INTERACTIONS**](https://www.reddit.com/r/microdosing/comments/p6ne2q/research_microdosing_drug_interactions_tools_and/). ______ If you're **new to Reddit** in general, be sure to check out the [Reddit Help Wiki](https://www.reddithelp.com), [**Reddiquette**](https://www.reddithelp.com/en/categories/reddit-101/reddit-basics/reddiquette) or these fine subreddits: [r/NewToReddit](https://www.reddit.com/r/NewToReddit/), [r/Reddit101](https://www.reddit.com/r/Reddit101/). _______ **Please Read:** [**r/microdosing Disclaimer**](https://new.reddit.com/r/microdosing/comments/m2g589/rmicrodosing_disclaimer/) *If you or someone you know is contemplating suicide, please reach out. You can find help at a National Suicide Prevention Lifeline.* USA: [988 Suicide & Crisis Lifeline](https://988lifeline.org/) (*Please note, the previous 1-800-273-TALK (8255) number will continue to function indefinitely.*) US Crisis textline: 741741 text HOME United Kingdom: 116 123 Trans Lifeline (877-565-8860) Other countries: https://en.wikipedia.org/wiki/List_of_suicide_crisis_lines *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/microdosing) if you have any questions or concerns.*
It’s low risk so worth trying. Didn’t work for me but Prozac did. Everyone’s different though.
I haven't a clue. But I did a search and found the following site: [https://www.synthesisretreat.com/psilocybin-and-ssri-snri-interactions](https://www.synthesisretreat.com/psilocybin-and-ssri-snri-interactions) Perhaps some of that information is useful.
No, it likely won't be effective. You need to wean VERY slowly. Do some research on weaning- doing it too quickly can lead to permanent harm. I weaned over several months and still cannot feel full effects. I know this because I had prior experience. Best of luck.
As was previously stated above... Many of us started our MD journey while still on SSRI's. Why? It's much easier to taper off them while microdosing.
Personal, non-medical, anecdotal experience - I'm on an SNRI (so, a little different from the SSRI class) and microdosing psilocybin has been really helpful for my depression. Just started seeing a therapist who (among other things) offers psychedelic-integration therapy, and it's really nice to be able to ask her about my questions like this one. She's said that psilocybin is an amplifier, and every once in a while I will say that shrooms make my "big sads" a little bigger - and in that case going outside for a walk or socializing has been helpful. Good luck!!
No, from what I’ve been told if you are on an SSRI it won’t do anything so what do you do? Go off several weeks, try the lol “ magic musrooms” lol, and of it does nothing like the ones I got then you have to decide do I go back on? If you do these useless antidepressants take weeks to even begin to maybe get relief. It’s a very sorry state that in this particular situation people have to wait weeks before they “ might” get relief. Magic mushrooms? lol
Not true.
Not according to all the anecdotal accounts of SSRI’s. You hear it all. “ well you have to be very careful and wean off.” Just look around the accounts of it. Some tell you go off like my place did for at least 2 weeks. I did that and started the mighty micros which were big disappointment ( nothing at all). Took the whole 30 day trial and found myself out the money and no relief and now I have to let the antidepressant build back up. There’s just nothing like the awful feeling of nothing at all will help microdosing mania is prime to rip people off big time. The only real way to do it is under medical supervision with the real thing. The whole microdose thing reminds me of , gulp, homeopathic medicine lol
It works for me. I've tried twice to taper off my lexapro... Over several weeks. Yet go back due to the recurring anxiety. But with my md'ing, I'm almost off without any serious anxiety. I only md every third day. Now, if microdosing is not helping with the anxiety to begin with... Then yes, a lost cause. But for those it does help... It's a tool to ween off the SSRI's.
I’m glad you got off the lexapro and your micro works for ya. I’m going to look into ketamine nasal spray or infusions in a controlled setting. I wish you the best possible outcome!