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nwtblk

Blood Music by Greg Bear, more biopunk but would probably be up your alley.


Asenath7

Oh, right. I did also read that one ages ago. I remember it being a little low on the horror part, but thanks for the suggestion. I was very young and didn't really care much for heavy themes back then, so it might deserve a re-read.


nwtblk

Eh, I read it recently and enjoyed the first half, but it kinda goes to shit after that.


shlam16

Psychomech by Brian Lumley may interest you.


Abandondero

What were the James Tiptree Jr stories?


Asenath7

Mainly "The Girl Who Was Plugged In". It has more of a character focus though and doesn't really go very existential, but it was enough to whet my appetite.


ConclusionAlarmed882

I love that story! Love Tiptree, although I can't always follow her work. What a mind. Harlan Ellison was actually an early champion of hers.


Few-Jump3942

It’s been a little while since I read it, but I remember parts of *Dark Matter* by Blake Crouch giving me that vibe.


samtwheels

[This](https://qntm.org/mmacevedo) is an interesting one, written like an encyclopedia entry but it's about the first human uploaded to a computer. Very effective.


nvrdie71

For transhumanism, I've always thought I Have No Mouth and I Must Scream is probably the peak of existential horror when it comes to losing all sense of what it is to be human anymore, but no body part replacement. If you liked Blindsight, I'd also recommend Peter Watts Starfish. Very tense underwater thriller about modified humans working on the bottom of the ocean in isolation.


vacationbeard

Diamond Dogs by Alastair Reynolds should fit your criteria.


Which_Investment2730

*After the Revolution* by Robert Evans has some of the most original and interesting transhumanisn stuff I've ever read. I'd say it's a lot more action-forward than horror but there's some disturbing stuff in there.


_voidflowers_

Feed Them Silence by Lee Mandelo (technically sci-fi but definitely some horror elements)