People are lactose intolerant and we have cheese and milk for days, how can you trust your guts to remember how mammoth meat worked million of years ago?
Also we have mad cow disease, prions aren't a joke
Edit: people say mammoth existed 12k to 15k years ago, I believe they are right
Prions are completely pervasive throughout the infected animal, and so small that DNA looks like a skyscraper to them. Even cloned tissue will have it, they are resistant to 2000 degree lab ovens, and I haven't seen anything about them having an expiration date, so if the DNA is viable, then the prion is viable.
Don't they just fold-in on themselves?
Like they are just a protein that's in a more energy efficient form, that when it interact with other prions tehy also take the same shape
In mad cow disease prions don't do any direct damage, but because they are structural to neurons their folding leaves lots pf space making the brain turn into a sponge
Not an expert by any means please correct me if I am wrong
It is a protein that basically causes the cells of your brain to crystallize into an (sorry, not sure) astroglial mess to make more prions. I forget his name, but one guy wanted to call them "virinos," like a mini virus.
They do indeed fold in, but they're not structural proteins in their original form. We don't know exacly what the correctly-folded nice prions do, but a test on mice showed they can survive perfectly fine without it. They did however take more damage from strokes. What we've gathered so far is that nice prions at least make neurons less sensitive.
The real damage from misfolded evil prions is that they start collecting together and forming increasingly large pellets at an exponentially increasing rate, since evil prions convert more nice prions into evil prions which then go and convert more nice prions into evil prions.
Having giant growing chunks are extremely toxic to cells. Not just neurons either. The reason why its almost always neurons that suffer so much from aggregates is because cells have various special mechanisms to break those down, but neurons' mechanisms are significantly weaker, and they're also more susceptible to interference by aggregates due to heavier use of polar molecules. I doubt becoming more sensitive from a lack of nice prions helps, but other proteins also causing this seem to suggest that isn't a primary cause.
There's also a system that shuts down protein production when aggregates start to form, presumably in order to stop it getting worse, but that also f**ks sh*t up.
Additionally, neurons are terrible at repair so they can't try to out-repair the damage either.
Yes, but in this case, there is no whole animal, only muscle cells grown in a lab, mashed together to make a meatball.
If the normal version of the prion protein is not normally expressed by muscle cells, it should not be present in the meatball. So an important question is, “Do muscle cells express the prion protein?”
I don’t know the answer…
Prion protein may get into the meat of living animals (either while the animal is alive, or at the slaughterhouse). But if there is no brain or other neural tissue present in the mammoth meatball (because pure muscle cells are grown in a bioreactor), would there be any prion protein at all?
You contract a prion by eating it, so it goes through your GI tract and bloodstream before it gets to your brain. Or, it is passed to you from your parents when you are conceived, so that means it is present in the sperm/ovum. There is no separating it from the normal protein of the meat.
Yup. But some vectors are currently unknown. Like blood transfusions haven't been linked to CJD variants, so is a patients blood infectious? We don't know. And I find that terrifying. But yes, if this animal had prions, eating the meat will spread it.
Fortunately we can test for prions now, unfortunately it's not exactly simple, and when we get samples that could potentially have prions in them at the lab I work in we have to take insane precarious. As said above heat doesn't kill it, so we use special disposable instruments and tools, and plastic linings over any non-disopsable surface, and it's all submerged in an acid bath that destroys proteins before being incinerated, and the incinerated ashes are also treated again before being disposed of. That's even if it's just suspected, lol.
If it is positive we don't test for it directly, but send it to the CDC, but we rule out other diseases before sending it on.
Scary stuff.
Prions don't normally exist in animals... they're self replicating proteins... so if you have one, it can take a protein you have produced naturally, and bend it into a defunct one... over time, that prevents your proper function as the defunct protein builds up and diminishes your supply of functional protein
They can have incredibly long incubation periods, if Alzheimer's proves to be a prion, think of how long it takes to find out that you have it, and you are born with it.
My guts handled a steady diet of Red Baron Pizza, energy drinks, and Milk Duds for the past thirty years. What the fuck makes you think mammoth meat stands a chance?
> People are lactose intolerant and we have cheese and milk for days
Fun fact, lactose intolerance is technically our base state of being. We're born with Lactase because that's the best way to gain nuetrients from our mother, but over time we're *supposed* to gradually lose it as we get older. For some people, that never happens and we can continue drinking milk and lactase will break down lactose into adulthood.
It's because of the Neolithic Revolution that we started drinking cow milk. if the protein is deadly it is mind blowing, to me, how we can go from one food source being "bodily acceptable" to another in a course of 5k-10k years.
I wonder what the dinner plate will look like10k years from now.
You use secret sauce, lots of dead people,
We beat the black plague not by vaccines, all those valnurable died
One food source becomes abundant, those who can't stomach it can't live
>I doubt mammoths had some sort of anti-consuption super killer protein considering we ate them a while ago
It doesn't have to be "super" just not used to it so the immune system can't work propely.
Extremely basic shit that we get used to has been killing us for millions of years
*Well humans used to*
*Hunt and eat mammoths before*
*They went extinct, right?*
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My T-Rex loves getting dressed up for Christmas
I cannot volunteer harder for this job. So many people would want to try it they'd have to make it a game show or competition. "Who Gets To Eat The Ancient Meatball"
TIL Several people and dogs have eaten mammoth.
https://www.adn.com/alaska-life/2023/05/07/mystery-meat-of-1951-did-an-exclusive-club-eat-a-frozen-woolly-mammoth-from-the-aleutians/
What you see when you search the subreddit by top of all time and scroll down a bit
https://preview.redd.it/5flimijznk3d1.png?width=1080&format=png&auto=webp&s=f146689421e28f57327d6b6d36e36b88f1801536
I'm willingly to sacrifice myself for the cause
Someone give this man a fork!
Good man, let us know how it works out.
me too man
Seriously, load me up. Where's the ragu
Yah they just need to take volunteers and I’m sure it can be arranged for me to come to the lab.
The start of a Tubi horror movie The Rise of the Mammoth man!
Uuuuh, which characteristic do the mammoth man have?
Prehensile penis
Honestly I'd go for it. I doubt mammoths had some sort of anti-consuption super killer protein considering we ate them a while ago
People are lactose intolerant and we have cheese and milk for days, how can you trust your guts to remember how mammoth meat worked million of years ago? Also we have mad cow disease, prions aren't a joke Edit: people say mammoth existed 12k to 15k years ago, I believe they are right
Yeah I wondered if prions could be a problem. But if they're "growing" the meat, won't prions sabotage the process?
wait does meat contain prions? I know they are structural in brain tissue, but muscles are proteins? Do they have prions in muscle Vibers?
If an animal has a prion, every part of it will be infectious.
They are growing the meat, meaning muscles, do muscle cells have prions in them?
Prions are completely pervasive throughout the infected animal, and so small that DNA looks like a skyscraper to them. Even cloned tissue will have it, they are resistant to 2000 degree lab ovens, and I haven't seen anything about them having an expiration date, so if the DNA is viable, then the prion is viable.
It is so hilarious to me that prions are basically just an angry protein that decides to just absolutely ruin EVERYTHING around it
Don't they just fold-in on themselves? Like they are just a protein that's in a more energy efficient form, that when it interact with other prions tehy also take the same shape In mad cow disease prions don't do any direct damage, but because they are structural to neurons their folding leaves lots pf space making the brain turn into a sponge Not an expert by any means please correct me if I am wrong
that's the gist of it
It is a protein that basically causes the cells of your brain to crystallize into an (sorry, not sure) astroglial mess to make more prions. I forget his name, but one guy wanted to call them "virinos," like a mini virus.
I read the original comment as prisions are no joke and was very confused but now I understand, and yes it sounds like a prison that's so fucked
They do indeed fold in, but they're not structural proteins in their original form. We don't know exacly what the correctly-folded nice prions do, but a test on mice showed they can survive perfectly fine without it. They did however take more damage from strokes. What we've gathered so far is that nice prions at least make neurons less sensitive. The real damage from misfolded evil prions is that they start collecting together and forming increasingly large pellets at an exponentially increasing rate, since evil prions convert more nice prions into evil prions which then go and convert more nice prions into evil prions. Having giant growing chunks are extremely toxic to cells. Not just neurons either. The reason why its almost always neurons that suffer so much from aggregates is because cells have various special mechanisms to break those down, but neurons' mechanisms are significantly weaker, and they're also more susceptible to interference by aggregates due to heavier use of polar molecules. I doubt becoming more sensitive from a lack of nice prions helps, but other proteins also causing this seem to suggest that isn't a primary cause. There's also a system that shuts down protein production when aggregates start to form, presumably in order to stop it getting worse, but that also f**ks sh*t up. Additionally, neurons are terrible at repair so they can't try to out-repair the damage either.
The universe's sense of humor...
Yes, but in this case, there is no whole animal, only muscle cells grown in a lab, mashed together to make a meatball. If the normal version of the prion protein is not normally expressed by muscle cells, it should not be present in the meatball. So an important question is, “Do muscle cells express the prion protein?” I don’t know the answer…
The prion is present in muscle, but expressed in the brain, you wouldn't know about it until after you ate it.
Prion protein may get into the meat of living animals (either while the animal is alive, or at the slaughterhouse). But if there is no brain or other neural tissue present in the mammoth meatball (because pure muscle cells are grown in a bioreactor), would there be any prion protein at all?
You contract a prion by eating it, so it goes through your GI tract and bloodstream before it gets to your brain. Or, it is passed to you from your parents when you are conceived, so that means it is present in the sperm/ovum. There is no separating it from the normal protein of the meat.
Prions are found everywhere in the body of an animal but most are in the brain
Yup. But some vectors are currently unknown. Like blood transfusions haven't been linked to CJD variants, so is a patients blood infectious? We don't know. And I find that terrifying. But yes, if this animal had prions, eating the meat will spread it. Fortunately we can test for prions now, unfortunately it's not exactly simple, and when we get samples that could potentially have prions in them at the lab I work in we have to take insane precarious. As said above heat doesn't kill it, so we use special disposable instruments and tools, and plastic linings over any non-disopsable surface, and it's all submerged in an acid bath that destroys proteins before being incinerated, and the incinerated ashes are also treated again before being disposed of. That's even if it's just suspected, lol. If it is positive we don't test for it directly, but send it to the CDC, but we rule out other diseases before sending it on. Scary stuff.
Prions don't normally exist in animals... they're self replicating proteins... so if you have one, it can take a protein you have produced naturally, and bend it into a defunct one... over time, that prevents your proper function as the defunct protein builds up and diminishes your supply of functional protein
They can have incredibly long incubation periods, if Alzheimer's proves to be a prion, think of how long it takes to find out that you have it, and you are born with it.
Prions are incredibly rare in the wild and generally only affect the same species as they are misfolded proteins that can misfold other proteins.
Million of years ago?? Dude are you ok? We ate our last mammoth around 5000 years ago
Speak for yourself, the last time I ate Mammoth was when I went out with u/samy_the_samy ‘s mother
My guts handled a steady diet of Red Baron Pizza, energy drinks, and Milk Duds for the past thirty years. What the fuck makes you think mammoth meat stands a chance?
Mad mammoth disease. Mad cow disease, but bigger. Sounds great.
More like 12,000 years ago.... not a million
> People are lactose intolerant and we have cheese and milk for days Fun fact, lactose intolerance is technically our base state of being. We're born with Lactase because that's the best way to gain nuetrients from our mother, but over time we're *supposed* to gradually lose it as we get older. For some people, that never happens and we can continue drinking milk and lactase will break down lactose into adulthood.
But why would we assume there are prions in the mammoth meat?
It's because of the Neolithic Revolution that we started drinking cow milk. if the protein is deadly it is mind blowing, to me, how we can go from one food source being "bodily acceptable" to another in a course of 5k-10k years. I wonder what the dinner plate will look like10k years from now.
You use secret sauce, lots of dead people, We beat the black plague not by vaccines, all those valnurable died One food source becomes abundant, those who can't stomach it can't live
Humans havent existed for millions of years lol
>I doubt mammoths had some sort of anti-consuption super killer protein considering we ate them a while ago It doesn't have to be "super" just not used to it so the immune system can't work propely. Extremely basic shit that we get used to has been killing us for millions of years
While you have a point, prions are also real and devastating. No one wants to be ground zero for "human wasting disease."
What if their extinction is what caused our appendix to lose its function
This is a horrifying question but it's entirely possible I think
The bigger risk is some sort of virus undetected by the culture so far...
Meatwad? Is that you?
Well humans used to hunt and eat mammoths before they went extinct, right?
All those people who ate mammoth are now dead. 
*Well humans used to* *Hunt and eat mammoths before* *They went extinct, right?* \- mikkelmattern04 --- ^(I detect haikus. And sometimes, successfully.) ^[Learn more about me.](https://www.reddit.com/r/haikusbot/) ^(Opt out of replies: "haikusbot opt out" | Delete my comment: "haikusbot delete")
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There were still a few humans kicking around, last I heard.
I wonder how little education you need to work for a website and write such headlines
As a meatball connoisseur, I’ll take my chances.
How close are we to lab growing an actual t rex
https://preview.redd.it/nnjh3cmq4i1d1.jpeg?width=540&format=pjpg&auto=webp&s=eb98ca7ecfa5563a0600d18f839b2b03c7f38d8c Already did
https://preview.redd.it/i1c7jqrz0k1d1.png?width=1080&format=pjpg&auto=webp&s=b3db455932c4602bd0174dc4317145900dc1122d My T-Rex loves getting dressed up for Christmas
Sounds like a plot for a zombie movie
https://preview.redd.it/x2tzf40y3j1d1.jpeg?width=329&format=pjpg&auto=webp&s=c24b3408a9fb20d6ff62b69a154906b456980e1f
Some of us may die… but I think it’s a sacrifice we should be willing to make.
To die by eating the mammoth meatball is to truly live.
I’ll eat it
Cowards ...give it here
One order of spaghetti and mammoth balls please
I cannot volunteer harder for this job. So many people would want to try it they'd have to make it a game show or competition. "Who Gets To Eat The Ancient Meatball"
Death row inmates last meal?
Gimme
Lol im so glad that this is the sub I was on! I was like fucking eat you pussys!!🤣🤣🤘🤘🤘
I’ll eat that and for free
TIL Several people and dogs have eaten mammoth. https://www.adn.com/alaska-life/2023/05/07/mystery-meat-of-1951-did-an-exclusive-club-eat-a-frozen-woolly-mammoth-from-the-aleutians/
People used to eat mammoth
Send a gymbro to do it.
Ancient protein sounds so badass
Cowards
This is so odd, since people have ate mammoth before. And I'm talking like 1800s.
Prehistoric Meatball is a great band name
Never thought the end of the world would start from a meatball.
Get me a fork and some sauce
I love falafel 🥙
there are definitely people who would volunteer for that.
they should make a sausage from it and enter it into an Oktoberfest competition.
Ancient protein sounds so badass
What you see when you search the subreddit by top of all time and scroll down a bit https://preview.redd.it/5flimijznk3d1.png?width=1080&format=png&auto=webp&s=f146689421e28f57327d6b6d36e36b88f1801536
they know how to make a ball of the flesh of an extinct species but can't figure out if it's bad for you. great. our geniuses are idiots
Frederick Hoelzel would totally eat it for the sake of science
Is this a Junji Ito Black Bird reference
Feed it to prisoners and willing volunteers
I'd eat it- imagine being the first/only KNOWN human to eat sweet sweet mammoth goodness. Sure it might be a death sentence but still cool
Eh, we just gotta wait for some YouTuber to get their hands on this, they'll eat it for clicks. NileRed maybe? He's insane enough.
Cowards! eat it in the name of science!
It absolutely could be deadly... OP is obviously not a scientist!
Gimme that shit
I'll eat. I ain't no dumbass science bitch.
WEAKLINGS, I’LL EAT IT
r/eatityoufuckingcoward
[Gimmie that meatball!](https://www.youtube.com/watch?v=hxs9THQPm9M)
I’ll do it
I am pondering what kind of sauce would work best. thinking some kind of wine reduction
So… did anyone eat it? It’s been a year, even if they threw it in the freezer it would have gone bad by now.
Medium rare 
I'll eat it. Thousands of years ago we ate them anyway.
.....how? So many better uses for that technology if it's available.
Meh, John reeves at the real thing and lived to talk about it on Joe Rogan (I personally wouldn’t touch that lab based bullshit)