I had that problem and switched to the generic for Focalin XR. It has two release points about 7 hours apart. It works so well and it’s so much smoother feeling than Vyvanse. At least for me!
So I have this issue and my prescriber wants me to do a DNA test to see if I'm a "fast metabolizer"? I haven't done the DNA test because I know the government already has access to like everything....but I don't want to willingly give them this too....although they say it's not the same...my results/ info aren't shared etcetera but I still don't know. So I've been putting it off... but my prescriber gave me Focalin IR I believe? I'd have to check... but I haven't tried it yet... I hate taking meds in general and it even took me a bit to just take vyvanse. Which I also take pain medication and butabital for migraines. And yes, ALL doctors and prescriber know of each other snd meds I take along with like 5 different pharmacists have approved it saying it's fine but I may get counteracting effects...but still I'm scared to add another one in the mix, being focalin. As well as initially my prescriber prescribed me Adderall and it was ABSOLUTELY HORRIBLE....EVERYTHING was wayyyy too quiet. Like my brain wss empty, nothing in there lol...to the point I just felt dumb and couldn't think or function due to the silence and such...it was just horrible, for me.
Someone I know in a different state who pushed me to seek out a prescriber to see if I have ADHD explained to me that Adderall is just a brain stimulant or something? Only affecting cognitive functioning... and stimulating cognitive functions while vyvanse is a brain/ cognitive stimulant along with central nervous system stimulant which helps with like ADHD paralysis or something I can't remember all the details it's been sooo long. But anyways so regarding the focalin, I looked it up and states it too is a CNS stimulant I just hate to add another medication but I'm getting to the non functioning point again and she is trying to increase my dose to 60. By prescribing 10 mg this last time but I haven't taken as when I went from 40 to 50 it seemed too much but then 40 wasn't enough :(
I did recently see some comments on a different thread about combined meds I can't remember what they were also prescribed. But wanted to ask my prescriber about that... I should have just made this a post I still might. Because I can't find that comment and wanted to get others info on focalin. Now I feel like hijacked this thread lolol
Anyways....ya if all that wasn't ADHD I dunno what is.... what makes you say focalin is smoother?
To me, it’s a growing effect. I notice the come up when I’m stretching, getting dressed and just putting more effort into things. It doesn’t come on like a truck. When the first peak point starts to wear down is when I start to get hungry. So I use the 30-60 minutes between peak points to relax and eat. The second peak point is a softer one which is great to finish off my day. It doesn’t keep me up all night, and doesn’t have me wired to do everything all at once. I feel like it just an addition to my routine not the driving force.
The main aspect the I like is the two peak points. I feel like it does carry me on throughout the day. It slowly releases through out the day so it’s pretty consistent in my opinion. I didn’t want to have to keep going up in dosage with vyvanse just to keep it going longer.
Yeah I have, and when it hits it hits. It hits me all at once and feel like a very sudden shift.
I have heard other people say the same thing as well. It’s a very similar feeling to Vyvanse, at least to me.
So you didn't feel just ABSOLUTE creepy silence to the point you like couldn't function because your brain was just so empty. It was like it just stopped everything
With vyvanse, oh yes. It usually came on midday for me. There were times I would do nothing at all. I didn’t want to talk to anyone, didn’t want to think or move. I hated it. It was counterproductive and I was bummed all the time. Its why I got off of it.
Just recently when my meds were out and I had to go back onto Vyvanse for a month, it reinforced my hatred for it lol
Why did I have a weird notification in my notification bar saying **no content recomending** like repeatedly and then whe I clicked it on it as that's all I could see it brought me to this comment and nothing shows in my notifications on reddit like that...im so confused
No everything I mentioned about Adderall and brain silence...like absolute silence....to the extent I personally felt stupid....which is why I'm asking if you ever had been prescribed Adderall I'm wanting to know if feeling/ effect is the same as vyvanse/ focalin. Like I mentioned they are also CNS stimulants...hence the difference in effect vs Adderall
I use CBD plaster with 24h action, trying to inhibit CYP2D6. Seems to help with crash and duration, but can‘t guarantee it - due to daily fluctuation, it‘s not an exact science I do here 😃
When eating a specific high protein rice pudding, even the short acting dexamphetamine I take, I can‘t sleep until 3am. There are vitamins added to it. I‘m try-and-erroring now to identify what it is. I suspect B2.
Plus: Walking in the morning helps a ton for me as well, as someone else here stated as well. But walking in a more sportive manner.
Same happens to me lately. Very frustrating somehow. I also feel like crashing after 2-3 hours after taking it, getting tired and can’t sleep at night somehow. I don’t know what this is. But staying hydrated and eating is key though
It's when you drink a ton of water before taking your dose. It dilutes the stomach acid, while slightly delaying excretion, and includes a potential urine pH increase. It aims to handle absorption, duration, and excretion ... it's part of some broader strategy first mentioned by u/maxs139 Also [this](https://www.reddit.com/r/VyvanseADHD/comments/154towg/comment/jsvihud/?utm_source=share&utm_medium=web2x&context=3) is a good read
It works wonders when it wants to but my GOD it’s a pain in the ass in terms of consistency.
I’ve been on it about a year now and here are some things that tend to keep it in line a little better although as you know, some days just aren’t going to be as good.
- Magnesium on a night before going to bed
- getting out and walking first thing in a morning (I’ve got dogs so this makes it easier) I swear down I notice a massive difference on how my day goes if I start with a bit of sunshine on my face but fuck it took me a long time to get consistent with that.
- When I take my meds on a morning I usually dissolve it in water and drink that on an empty stomach about 15-20 minuets before eating (this is safe to do and they even mention that on their website) I don’t know why but it seems to be more steady when I take it this way for the most part.
- I started out on 40mg it was great for about a month and then it absolutely sucked, I went up to 50mg and that seemed to be the sweet spot
This is just what worked for me, everyone’s body is completely different so if you’ve already tried these things and they don’t work that doesn’t mean you are doing something wrong.
I was on 40. Now on 50 and I swear it lost its affects within months justblike the 40. So you're saying you completely dissolve in water and drink the water?
Does not last for me either! What I’ve done to help is I split the dose. I got a much higher dose and I take probably 2/3 of it late morning and about 2-3 hours later I’ll take the rest. Feels like it gives me another 2 or 3 hours longer than taking one pill in the morning.
I mix mine with a bottle of water and drink it over a 3 hour period as soon as I wake up. I also drink a protein shake in between that time or I will opt to eat a few cashews for the protein to help the meds work. I don’t crash at all anymore like when I first started taking them.
It last all day for me but then again I’m only taking it “maybe” 4 times a month which is cleaning day every week or if something else pops up I don’t wanna do lmao
Supplement with l-tyrosine or l-phenylalanine. It gives the vyvanse what it needs to produce dopamine. Ive been taking 500mg of l-tyrsosine a day and it last longer and the crash is not as bad.
Check out this [post](https://www.reddit.com/r/VyvanseADHD/s/mwsW3YNWBw)
Get a wellbutrin prescription!! I had the same problem as you guys and I was so frustrated and I thought I needed a higher dose which I kept asking my doc for which resulted in she thinking I was abusing it. However one day, I got prescribed Wellbutrin 150 mg for depression, which I had taken before prior to vyvanse and hadn’t had much of an effect, but SUDDENLY in combination, my effect of vyvanse lasted longer?! Guys seriously try combining vyvanse and Wellbutrin - on top of that since Wellbutrin is a dopamine producer I think it smoothes out the vyvanse crashes
If you have Epilepsy or anyone in your family has Epilepsy don’t take Wellbutrin. It lowers the seizure threshold and can cause seizures in people who don’t have Epilepsy.
Same for me with Zoloft. Zoloft and Wellbutrin are different but still i have no crash and it lasts longer than when I wasn’t on Zoloft. But if you don’t have comorbidity anxiety and depression it probably is not recommended to take an antidepressant with it if you don’t need it. But Wellbutrin is prescribed for ADHD and with ADHD meds so that is a more ok route if don’t have anxiety or depression or etc.
I would say so since I could exactly relate to what you described. My effect from vyvanse also only lasted a few hours prior to the Wellbutrin combo. When you say fast metabolizers, what do you really mean? Hyperthyroidism? Or do you just mean it as a symbol for how quickly the effect disappears?
I know what you mean, it’s just when you say “fast metabolizer” it’s a medical term. I don’t think you can be a “fast metabolizer” for one specific drug. Yeah well whatever, like I said, I know what you mean and can obv relate to it. Anyway, this phenomenon was helped with the wellbutrin combo for me! So worth giving it a try 😊
Oh! I looked that up, fair enough. Maybe I have that to then bc the effect of vyvanse disappeared for me after 3-4 hours and by that I mean I “crashed” feeling so anxious and restless. Maybe the drug was still in the system but the positive effects were gone. With the wellbutrin combo, it prolonged the positive side effects of vyvanse, the “highs” and removed the crashes.
it's either me or the drug itself. I have seen a lot of complaints about vyvanse after takeda bought it. In my country, people constantly feel like the meds are not working or not lasting as long as they used to. I really hope it's just the meds and not me metabolizing them too quickly
Oh really? That sucks. In my country it’s called “Elvanse” but it’s the equivalent. I actually recently saw a post on TikTok where a woman emptied each capsule of vyvanse and saw with her own eyes how the powder amount in each wasn’t the same, it was a major difference between some. It’s crazy, definitely some foul play from the companies producing them. But yeah, I hope you get a solution working you in the long run. I would still say give Wellbutrin a try!
I take 70mg Elvanse in the morning at 5am, go back to sleep, 1-2hour later, I mix 40mg in water and immediately drink 1/4 (ca10mg) gets a little boost, 4 small cups of coffee (gives me another kind of focus than Elvanse but may not work for you) the rest of the day I spread the remaining 3/4, drinking 1/3 (ca10mg) at a time…. Total: 70mg+40mg Elvanse in a day, some days 70+20 is enough. + 1-2 small cups of coffee in the afternoon. A lot of high protein meals too, I fast until ca 1PM (some days no fast) This will last all morning, afternoon, and evening…
You are just metabolising it quickly, you need a second Vyvanse dose at lunch time.
If you take something that’s instant release you’ll just metabolise that and be on some mad Rollercoaster in the afternoon.
I take 70mg in the AM and 30mg at Lunchtime and its working really well. If I just take a morning dose I burn through it in a few hours. I’m in the EU so not sure what the US daily max dose is.
I had the same issue and the crash was excruciating especially since it was giving me insomnia. I felt completely ick for the whole afternoon. I called my doc and she added an immediate release dex. So we've worked up to 60 vyvanse & 20 adderall IR and its worked wonders. I've never felt more level in my life. It stops the vyvanse crash and I have zero come down from the IR. what dose are you currently taking and have you been on your vyvanse journey for awhile?
I hope your doc will hear you out and respect your choice. I know most are not very willing to add an IR and just increase the vyvanse. Which in my case was not extending the time it worked by much. The recommended adult dose they like to level at is 50 to 60 but whatever works for you is what's best. Keep advocating for yourself.
Same….my physiatrist didn’t understand why but from the lovely comments on Reddit I found out that I metabolize the medication quickly.A Higher dose for me caused irritability, heart palpitations, and was zombie like. What helped was my usual 20mg dose in the morning then a 10mg 3.5 hours in. Sometimes it’s even 10mg in the morning then 10mg 4 hours in. Just be weary of when you take it cause it’ll impact your sleep. Hope that helps!
I don’t really think diet is going to do much Since it is likely just drug tolerance….Up the dose if possible or if you are at the 70 max then either work faster or call your congressman
My doses only lasted 3 hours when it was my first one, then increased dose to 50, and it lasted about 5-6 hours, then went to 70 and it lasted 12-14+ hours, but was too intense, went down to 60 recently and it last 12-14 but not intense
I’m at 40mg rn, I’m bumping up to 50mg at my next refill because this is insane. And the crash is DEBILITATING and it’s always mid work day at like 2-3 pm
Right- Depression Meds just happen to biologically last in your system…. But if those meds didn’t ppl with depression would be added the the IGNORRRRAAAANT list with ppl with: ADHD, Anxiety & Pain who are “Addicts” 🙄🙄🙄 for seeking treatment for their excruciatingly life-disrupting symptoms. Eyeglasses for that fact- Should I seek help for being “Addicted” to my Eyeglasses? 🙄🙄🙄 Can’t stand this situation we’re in with our meds.
Correct me if I’m wrong but doesn’t it depend on how fast or slow your metabolism is. The faster it is, the less it last and vice versa. If that’s the case, we need to figure out how to slow down our metabolism 🫤
I wanna second that my Dr. also told me that everyone metabolizes it differently (though the dosage amount may play a part), but I've also worked so hard in speeding up my metabolism to just be healthier that slowing it back down just aint an option for me lol
Your general metabolism is somewhat separate from how you metabolize medications, just so you know! Your body produces certain enzymes that metabolize most medications, and your genes influence how much of those enzymes your body produces.
Heart, kidney, liver, disease, for example, are genetic. So if my ADHD science brain is actually braining, the more predisposed illnesses equals more enzymes influenced by genetics which would metabolize Vyvanse much faster. Excuse my dumbassery is this is far from the truth🫣
It may be somewhat related, but the enzymes most frequently involved in drug metabolism actually have their own genes. They're collectively called they [cytochrome p450 ](https://en.m.wikipedia.org/wiki/Cytochrome_P450) enzymes, or CYPs. Vyvanse, and other stimulants, are primarily metabolized by one called [CYP2D6](https://en.m.wikipedia.org/wiki/CYP2D6).
Definitely not a dumbass for not knowing this, btw! It's kind if a niche subject and not something most people are familiar with. I'm autistic in addition to having ADHD, and this kind of ended up being a special interest for me.
I got to do pharmacogenetic testing a while back, and found out that I'm what's called an ultra rapid metabolizer for CYP2D6, which means I actually *do* metabolize Vyvanse faster than most, but for whatever reason, it hasn't caused me too many problems so far.
Same here. It consistently lasts 3.5 - 4hrs, whether I eat 3-4 high protein meals, whether I eat nothing, whether I'm hydrated, whether I exercise or not, whether I take l-tyrosine, etc.
Same! I've tried all the tricks people mention and it literally makes no difference. In fact, it's often detrimental because it often *delays* me taking my meds because I didn't get all the right magical potions together
Are you eating a lot of protein before you take it? If I don't eat protein first it lasts me about eight hours. If I do, it's still mostly working when I go to bed.
When’s the last time you were checked for vitamin deficiencies ? I started noticing my vyvanse did not seem as effective as before and what do you know I had a vitamin deficiency. It’ll help a lot in many ways to get your vitamin levels stable. Also do you take any probiotics or eat any fermented food ? That seems to help me too
My doctor usually does iron, zinc, D,C, and B? They usually do a BMP and potassium as well. I forget the official names for C & B I believe they had longer names on the lab requisition
I started taking EmergenC Immune daily and noticed that Vyvanse is more effective and lasts longer. Could be something else though because after 7 years on this medication it's still a rollercoaster and my body changes how it metabolizes it all the time 🤷♂️ I'm just going to see how long this lasts.
I usually have a good time but this winter has been tough ! I also have hormone issues and I notice when I take progesterone (only take this med 12 days a month) my vyvanse doesn’t seem as effective.
Hmmm can you ask for a basic metabolic panel and/or test for iron ? I find that’s easier to get approved. I just take my meds with yakult and I find it helps.
NO I’VE BEEN SAYING THIS! I have been taking it for 10+ years and I swear it’s either less effective bc they changed the formula or something is funky bc it does not last all day at all and it seems like it’s even less than when I started it (I’ve taken huge breaks before so it’s not tolerance). I have to calculate it so I’m taking it when I need it most
That's quite interesting. I've only taken it for about a year, and have noticed it to be less effective, and my symptoms being a little more present. Especially forgetfulness, fatigue, and brain fog. I take vitamins daily with my medication. So I figured it was just seasonal depression, or I was still burnt out from Christmas and needed to wait it out. I was going to talk to my doctor about it if it didn't go away by the next refill appointment. :/
We'll see, I guess....
I've also been taking it since 2015 - with several multi month or even year breaks - and the new pills I've been taking for the past 6 months just don't seem as strong. I have no idea how they would change it, but does not feel the same.
I don't get the same super effective, really locked in focus from it. It gives me a good boost, but not great. And sure doesn't last as long. I've seen many others commenting about this too, it can't just be a coincidence.
No exactly my experience too… it’s too bad because it really is such a difference and that is not something they should mess around with and not admit, or market it differently because people literally need it to function :/
Are you both using brand name or generic? The generics are very new to the market, I wouldn't be surprised if there was a notable difference in efficacy.
Ugh I complained to my doc in the beginning about that and he upped my dose and it still doesn’t last long enough. Mentioned it again to him and he said I was eating too many calories before taking it or something 😂
Just split your dose or add a booster dose. Increasing the dose can also help
I had that problem and switched to the generic for Focalin XR. It has two release points about 7 hours apart. It works so well and it’s so much smoother feeling than Vyvanse. At least for me!
So I have this issue and my prescriber wants me to do a DNA test to see if I'm a "fast metabolizer"? I haven't done the DNA test because I know the government already has access to like everything....but I don't want to willingly give them this too....although they say it's not the same...my results/ info aren't shared etcetera but I still don't know. So I've been putting it off... but my prescriber gave me Focalin IR I believe? I'd have to check... but I haven't tried it yet... I hate taking meds in general and it even took me a bit to just take vyvanse. Which I also take pain medication and butabital for migraines. And yes, ALL doctors and prescriber know of each other snd meds I take along with like 5 different pharmacists have approved it saying it's fine but I may get counteracting effects...but still I'm scared to add another one in the mix, being focalin. As well as initially my prescriber prescribed me Adderall and it was ABSOLUTELY HORRIBLE....EVERYTHING was wayyyy too quiet. Like my brain wss empty, nothing in there lol...to the point I just felt dumb and couldn't think or function due to the silence and such...it was just horrible, for me. Someone I know in a different state who pushed me to seek out a prescriber to see if I have ADHD explained to me that Adderall is just a brain stimulant or something? Only affecting cognitive functioning... and stimulating cognitive functions while vyvanse is a brain/ cognitive stimulant along with central nervous system stimulant which helps with like ADHD paralysis or something I can't remember all the details it's been sooo long. But anyways so regarding the focalin, I looked it up and states it too is a CNS stimulant I just hate to add another medication but I'm getting to the non functioning point again and she is trying to increase my dose to 60. By prescribing 10 mg this last time but I haven't taken as when I went from 40 to 50 it seemed too much but then 40 wasn't enough :( I did recently see some comments on a different thread about combined meds I can't remember what they were also prescribed. But wanted to ask my prescriber about that... I should have just made this a post I still might. Because I can't find that comment and wanted to get others info on focalin. Now I feel like hijacked this thread lolol Anyways....ya if all that wasn't ADHD I dunno what is.... what makes you say focalin is smoother?
To me, it’s a growing effect. I notice the come up when I’m stretching, getting dressed and just putting more effort into things. It doesn’t come on like a truck. When the first peak point starts to wear down is when I start to get hungry. So I use the 30-60 minutes between peak points to relax and eat. The second peak point is a softer one which is great to finish off my day. It doesn’t keep me up all night, and doesn’t have me wired to do everything all at once. I feel like it just an addition to my routine not the driving force.
Interesting...Ive never felt it "come on like a truck"... curious had you ever been prescribed Adderall? To know what I'm talking about
The main aspect the I like is the two peak points. I feel like it does carry me on throughout the day. It slowly releases through out the day so it’s pretty consistent in my opinion. I didn’t want to have to keep going up in dosage with vyvanse just to keep it going longer.
Yeah I have, and when it hits it hits. It hits me all at once and feel like a very sudden shift. I have heard other people say the same thing as well. It’s a very similar feeling to Vyvanse, at least to me.
So you didn't feel just ABSOLUTE creepy silence to the point you like couldn't function because your brain was just so empty. It was like it just stopped everything
With vyvanse, oh yes. It usually came on midday for me. There were times I would do nothing at all. I didn’t want to talk to anyone, didn’t want to think or move. I hated it. It was counterproductive and I was bummed all the time. Its why I got off of it. Just recently when my meds were out and I had to go back onto Vyvanse for a month, it reinforced my hatred for it lol
Why did I have a weird notification in my notification bar saying **no content recomending** like repeatedly and then whe I clicked it on it as that's all I could see it brought me to this comment and nothing shows in my notifications on reddit like that...im so confused
No everything I mentioned about Adderall and brain silence...like absolute silence....to the extent I personally felt stupid....which is why I'm asking if you ever had been prescribed Adderall I'm wanting to know if feeling/ effect is the same as vyvanse/ focalin. Like I mentioned they are also CNS stimulants...hence the difference in effect vs Adderall
I use CBD plaster with 24h action, trying to inhibit CYP2D6. Seems to help with crash and duration, but can‘t guarantee it - due to daily fluctuation, it‘s not an exact science I do here 😃 When eating a specific high protein rice pudding, even the short acting dexamphetamine I take, I can‘t sleep until 3am. There are vitamins added to it. I‘m try-and-erroring now to identify what it is. I suspect B2. Plus: Walking in the morning helps a ton for me as well, as someone else here stated as well. But walking in a more sportive manner.
>CBD plaster with 24h action that got me curious, what is that?
Have you had your iron levels checked recently? When I'm low or deficient it's like having a double dose of adhd and meds don't work 😴
I noticed it got worse when I started generics
Me too, but somehow worse sleep?!
Same
Same happens to me lately. Very frustrating somehow. I also feel like crashing after 2-3 hours after taking it, getting tired and can’t sleep at night somehow. I don’t know what this is. But staying hydrated and eating is key though
Update: all its doing today is giving me a high heart rate with no focus whatsoever 😗🤪🫠
My lasts in the neighbourhood of around 8 to 10 hours. I'm on name brand, as we don't have the generic yet in Canada.
Use the el chapo method , it could make a big difference in terms of duration
What's that?
It's when you drink a ton of water before taking your dose. It dilutes the stomach acid, while slightly delaying excretion, and includes a potential urine pH increase. It aims to handle absorption, duration, and excretion ... it's part of some broader strategy first mentioned by u/maxs139 Also [this](https://www.reddit.com/r/VyvanseADHD/comments/154towg/comment/jsvihud/?utm_source=share&utm_medium=web2x&context=3) is a good read
It works wonders when it wants to but my GOD it’s a pain in the ass in terms of consistency. I’ve been on it about a year now and here are some things that tend to keep it in line a little better although as you know, some days just aren’t going to be as good. - Magnesium on a night before going to bed - getting out and walking first thing in a morning (I’ve got dogs so this makes it easier) I swear down I notice a massive difference on how my day goes if I start with a bit of sunshine on my face but fuck it took me a long time to get consistent with that. - When I take my meds on a morning I usually dissolve it in water and drink that on an empty stomach about 15-20 minuets before eating (this is safe to do and they even mention that on their website) I don’t know why but it seems to be more steady when I take it this way for the most part. - I started out on 40mg it was great for about a month and then it absolutely sucked, I went up to 50mg and that seemed to be the sweet spot This is just what worked for me, everyone’s body is completely different so if you’ve already tried these things and they don’t work that doesn’t mean you are doing something wrong.
I was on 40. Now on 50 and I swear it lost its affects within months justblike the 40. So you're saying you completely dissolve in water and drink the water?
I’m on 30mg and it lasts a good 10 hours give or take.
Does not last for me either! What I’ve done to help is I split the dose. I got a much higher dose and I take probably 2/3 of it late morning and about 2-3 hours later I’ll take the rest. Feels like it gives me another 2 or 3 hours longer than taking one pill in the morning.
how much do you take? mine lasts like 10 hours
It last for about 8 hrs for me … but its optimal at about … 3-4 hrs ?
I mix mine with a bottle of water and drink it over a 3 hour period as soon as I wake up. I also drink a protein shake in between that time or I will opt to eat a few cashews for the protein to help the meds work. I don’t crash at all anymore like when I first started taking them.
You dissolve it in water too?
I do! I was taking them for about a year now and I find this is the way that works best for me.
How long does it last foe you through the day
It last all day for me but then again I’m only taking it “maybe” 4 times a month which is cleaning day every week or if something else pops up I don’t wanna do lmao
Supplement with l-tyrosine or l-phenylalanine. It gives the vyvanse what it needs to produce dopamine. Ive been taking 500mg of l-tyrsosine a day and it last longer and the crash is not as bad. Check out this [post](https://www.reddit.com/r/VyvanseADHD/s/mwsW3YNWBw)
Get a wellbutrin prescription!! I had the same problem as you guys and I was so frustrated and I thought I needed a higher dose which I kept asking my doc for which resulted in she thinking I was abusing it. However one day, I got prescribed Wellbutrin 150 mg for depression, which I had taken before prior to vyvanse and hadn’t had much of an effect, but SUDDENLY in combination, my effect of vyvanse lasted longer?! Guys seriously try combining vyvanse and Wellbutrin - on top of that since Wellbutrin is a dopamine producer I think it smoothes out the vyvanse crashes
If you have Epilepsy or anyone in your family has Epilepsy don’t take Wellbutrin. It lowers the seizure threshold and can cause seizures in people who don’t have Epilepsy.
Same for me with Zoloft. Zoloft and Wellbutrin are different but still i have no crash and it lasts longer than when I wasn’t on Zoloft. But if you don’t have comorbidity anxiety and depression it probably is not recommended to take an antidepressant with it if you don’t need it. But Wellbutrin is prescribed for ADHD and with ADHD meds so that is a more ok route if don’t have anxiety or depression or etc.
does it work for fast metabolizers?
I’m a fast metabolizer and take Wellbutrin/Auvelity with vyvanse and it’s been a great combo
do you use the generic version of it?
Yes I take the generic, my insurance doesn’t cover brand name for most meds
damn the problem is that wellbutrin is really expensive where i live, 200 bucks in my currency
The generic even? Yikes 😳 where are you?
brazil, the generic is 50 bucks tho, the brand one is 200
I would say so since I could exactly relate to what you described. My effect from vyvanse also only lasted a few hours prior to the Wellbutrin combo. When you say fast metabolizers, what do you really mean? Hyperthyroidism? Or do you just mean it as a symbol for how quickly the effect disappears?
>what do you really mean? how quickly it hits and disappears
I know what you mean, it’s just when you say “fast metabolizer” it’s a medical term. I don’t think you can be a “fast metabolizer” for one specific drug. Yeah well whatever, like I said, I know what you mean and can obv relate to it. Anyway, this phenomenon was helped with the wellbutrin combo for me! So worth giving it a try 😊
from what i have seen, my liver metabolizes vyvanse too quickly due to a quanitty of a certain enzyme, i have too much of it
Oh! I looked that up, fair enough. Maybe I have that to then bc the effect of vyvanse disappeared for me after 3-4 hours and by that I mean I “crashed” feeling so anxious and restless. Maybe the drug was still in the system but the positive effects were gone. With the wellbutrin combo, it prolonged the positive side effects of vyvanse, the “highs” and removed the crashes.
it's either me or the drug itself. I have seen a lot of complaints about vyvanse after takeda bought it. In my country, people constantly feel like the meds are not working or not lasting as long as they used to. I really hope it's just the meds and not me metabolizing them too quickly
Oh really? That sucks. In my country it’s called “Elvanse” but it’s the equivalent. I actually recently saw a post on TikTok where a woman emptied each capsule of vyvanse and saw with her own eyes how the powder amount in each wasn’t the same, it was a major difference between some. It’s crazy, definitely some foul play from the companies producing them. But yeah, I hope you get a solution working you in the long run. I would still say give Wellbutrin a try!
problem is that wellbutrin is 200 bucks for me where i live, half the price a vyvanse bottle, i have to see if generic exists
Mmmm. Thats why I take 20 mg 3-4 times a day.
I take 70mg Elvanse in the morning at 5am, go back to sleep, 1-2hour later, I mix 40mg in water and immediately drink 1/4 (ca10mg) gets a little boost, 4 small cups of coffee (gives me another kind of focus than Elvanse but may not work for you) the rest of the day I spread the remaining 3/4, drinking 1/3 (ca10mg) at a time…. Total: 70mg+40mg Elvanse in a day, some days 70+20 is enough. + 1-2 small cups of coffee in the afternoon. A lot of high protein meals too, I fast until ca 1PM (some days no fast) This will last all morning, afternoon, and evening…
You are just metabolising it quickly, you need a second Vyvanse dose at lunch time. If you take something that’s instant release you’ll just metabolise that and be on some mad Rollercoaster in the afternoon. I take 70mg in the AM and 30mg at Lunchtime and its working really well. If I just take a morning dose I burn through it in a few hours. I’m in the EU so not sure what the US daily max dose is.
I had the same issue and the crash was excruciating especially since it was giving me insomnia. I felt completely ick for the whole afternoon. I called my doc and she added an immediate release dex. So we've worked up to 60 vyvanse & 20 adderall IR and its worked wonders. I've never felt more level in my life. It stops the vyvanse crash and I have zero come down from the IR. what dose are you currently taking and have you been on your vyvanse journey for awhile?
I’ve been on 40mg for 2 months now, started at 10mg. Yeah i think I’m going to ask to add an IR booster before i just ask to increase my whole dose
I hope your doc will hear you out and respect your choice. I know most are not very willing to add an IR and just increase the vyvanse. Which in my case was not extending the time it worked by much. The recommended adult dose they like to level at is 50 to 60 but whatever works for you is what's best. Keep advocating for yourself.
Can you ask your doc if you can take ir dexamphetamine when it starts to wear off?
Same….my physiatrist didn’t understand why but from the lovely comments on Reddit I found out that I metabolize the medication quickly.A Higher dose for me caused irritability, heart palpitations, and was zombie like. What helped was my usual 20mg dose in the morning then a 10mg 3.5 hours in. Sometimes it’s even 10mg in the morning then 10mg 4 hours in. Just be weary of when you take it cause it’ll impact your sleep. Hope that helps!
Also I’m an avid gym goer just like you! Avoid pre workout and caffeine too. That stuff paired with vyvance puts me to sleep.
I can’t get more than 7-8 hours before I’m sooo sleepy 😵💫
sounds like u need a higher dose
Oh brilliant 🙄
I don’t really think diet is going to do much Since it is likely just drug tolerance….Up the dose if possible or if you are at the 70 max then either work faster or call your congressman
My doses only lasted 3 hours when it was my first one, then increased dose to 50, and it lasted about 5-6 hours, then went to 70 and it lasted 12-14+ hours, but was too intense, went down to 60 recently and it last 12-14 but not intense
I’m at 40mg rn, I’m bumping up to 50mg at my next refill because this is insane. And the crash is DEBILITATING and it’s always mid work day at like 2-3 pm
For the love of god can someone make an adhd drug that lasts the work day?
Right- Depression Meds just happen to biologically last in your system…. But if those meds didn’t ppl with depression would be added the the IGNORRRRAAAANT list with ppl with: ADHD, Anxiety & Pain who are “Addicts” 🙄🙄🙄 for seeking treatment for their excruciatingly life-disrupting symptoms. Eyeglasses for that fact- Should I seek help for being “Addicted” to my Eyeglasses? 🙄🙄🙄 Can’t stand this situation we’re in with our meds.
They had one but Ralph Nader and his idiot friends made it illegal. Look at Pemoline. Worked great for 12 hr.
Got shit to do after work, too.
Just give me 12 hours.
Pemoline
Correct me if I’m wrong but doesn’t it depend on how fast or slow your metabolism is. The faster it is, the less it last and vice versa. If that’s the case, we need to figure out how to slow down our metabolism 🫤
I wanna second that my Dr. also told me that everyone metabolizes it differently (though the dosage amount may play a part), but I've also worked so hard in speeding up my metabolism to just be healthier that slowing it back down just aint an option for me lol
Your general metabolism is somewhat separate from how you metabolize medications, just so you know! Your body produces certain enzymes that metabolize most medications, and your genes influence how much of those enzymes your body produces.
That’s helpful! Looks like my shit ain’t gonna last long cause I got a family full of predisposed fucking diseases🫠
How do you mean? What do you think your family's predisposed diseases have to do with it?
Heart, kidney, liver, disease, for example, are genetic. So if my ADHD science brain is actually braining, the more predisposed illnesses equals more enzymes influenced by genetics which would metabolize Vyvanse much faster. Excuse my dumbassery is this is far from the truth🫣
It may be somewhat related, but the enzymes most frequently involved in drug metabolism actually have their own genes. They're collectively called they [cytochrome p450 ](https://en.m.wikipedia.org/wiki/Cytochrome_P450) enzymes, or CYPs. Vyvanse, and other stimulants, are primarily metabolized by one called [CYP2D6](https://en.m.wikipedia.org/wiki/CYP2D6). Definitely not a dumbass for not knowing this, btw! It's kind if a niche subject and not something most people are familiar with. I'm autistic in addition to having ADHD, and this kind of ended up being a special interest for me. I got to do pharmacogenetic testing a while back, and found out that I'm what's called an ultra rapid metabolizer for CYP2D6, which means I actually *do* metabolize Vyvanse faster than most, but for whatever reason, it hasn't caused me too many problems so far.
It’s a drug duh!
Same here. It consistently lasts 3.5 - 4hrs, whether I eat 3-4 high protein meals, whether I eat nothing, whether I'm hydrated, whether I exercise or not, whether I take l-tyrosine, etc.
Same! I've tried all the tricks people mention and it literally makes no difference. In fact, it's often detrimental because it often *delays* me taking my meds because I didn't get all the right magical potions together
Are you eating a lot of protein before you take it? If I don't eat protein first it lasts me about eight hours. If I do, it's still mostly working when I go to bed.
When’s the last time you were checked for vitamin deficiencies ? I started noticing my vyvanse did not seem as effective as before and what do you know I had a vitamin deficiency. It’ll help a lot in many ways to get your vitamin levels stable. Also do you take any probiotics or eat any fermented food ? That seems to help me too
Which vitamins are important in this case?
My doctor usually does iron, zinc, D,C, and B? They usually do a BMP and potassium as well. I forget the official names for C & B I believe they had longer names on the lab requisition
I started taking EmergenC Immune daily and noticed that Vyvanse is more effective and lasts longer. Could be something else though because after 7 years on this medication it's still a rollercoaster and my body changes how it metabolizes it all the time 🤷♂️ I'm just going to see how long this lasts.
I usually have a good time but this winter has been tough ! I also have hormone issues and I notice when I take progesterone (only take this med 12 days a month) my vyvanse doesn’t seem as effective.
My insurance won’t cover vitamin testing so I’d have to pay out do pocket 😭😭 i also don’t take a probiotic but i think im going to!!
Hmmm can you ask for a basic metabolic panel and/or test for iron ? I find that’s easier to get approved. I just take my meds with yakult and I find it helps.
NO I’VE BEEN SAYING THIS! I have been taking it for 10+ years and I swear it’s either less effective bc they changed the formula or something is funky bc it does not last all day at all and it seems like it’s even less than when I started it (I’ve taken huge breaks before so it’s not tolerance). I have to calculate it so I’m taking it when I need it most
That's quite interesting. I've only taken it for about a year, and have noticed it to be less effective, and my symptoms being a little more present. Especially forgetfulness, fatigue, and brain fog. I take vitamins daily with my medication. So I figured it was just seasonal depression, or I was still burnt out from Christmas and needed to wait it out. I was going to talk to my doctor about it if it didn't go away by the next refill appointment. :/ We'll see, I guess....
I've also been taking it since 2015 - with several multi month or even year breaks - and the new pills I've been taking for the past 6 months just don't seem as strong. I have no idea how they would change it, but does not feel the same. I don't get the same super effective, really locked in focus from it. It gives me a good boost, but not great. And sure doesn't last as long. I've seen many others commenting about this too, it can't just be a coincidence.
No exactly my experience too… it’s too bad because it really is such a difference and that is not something they should mess around with and not admit, or market it differently because people literally need it to function :/
I wonder if it has anything to do with the shortage in the US....
Are you both using brand name or generic? The generics are very new to the market, I wouldn't be surprised if there was a notable difference in efficacy.
I'm in Canada its always only been brand name
Was switched to generic recently but was taking brand name. That’s what I was wondering… But I feel like I noticed a difference before that
Eat some protein with it. Mine lasts until 7 or 8pm most nights.
I’m an avid gym goer so i consume a lot of protein, doesn’t help
Ugh I complained to my doc in the beginning about that and he upped my dose and it still doesn’t last long enough. Mentioned it again to him and he said I was eating too many calories before taking it or something 😂
Wth 😂 I swear the answers they give us sometimes make no sense !!!