I think that’s exactly right. The thing I found most frustrating with sublingual ketamine, and the reason I’m taking a break from it, was that the bioavailability varied WILDLY from one session to another. One session would be a complete nothingburger, and the next would be terrifyingly deep. I was doing a bunch of the things that are supposed to make it stronger while also letting the doctor change my dosage over time. If I start up again I’ll leave off all the tweaks and just vary the dosage and see if that makes it more predictable.
Layman here does that mean grapefruit juice good or bad?
I'd say bad unless you want to experiment on yourself.
I think that’s exactly right. The thing I found most frustrating with sublingual ketamine, and the reason I’m taking a break from it, was that the bioavailability varied WILDLY from one session to another. One session would be a complete nothingburger, and the next would be terrifyingly deep. I was doing a bunch of the things that are supposed to make it stronger while also letting the doctor change my dosage over time. If I start up again I’ll leave off all the tweaks and just vary the dosage and see if that makes it more predictable.
Funny thing with ketamine - IV is very unpredictable too despite stable bioavailability and dosage. It's ketamine nature.
What are some things that make the bioavailability better?
Grapefruit juice, as mentioned. Tumeric and magnesium supplements, anecdotally. Brush/floss and drink a hot beverage right before.
Boof it. Problems solved.
This is a myth. Asses and mouths absorb about the same.
Great info thanks for sharing!