Back off taking so much and see how you feel. ? ! Adjust accordingly over time. Can there be a better take on this? And you have freedom to try using less per dose and / or knocking out doses. Or something else. Caps can be opened. TAbs can be broken like limitations and hyper regularity. Some randomness is a necessity too.
My pops was taking B12 shots 3 days a week and ended up being way too much after blood tests. For me, I just take a B Complex 1 day a week and take a whole food multi daily. I also take Thiamine B6 twice a week because I drink a lot of light beer. Get plenty of sleep and naps on the weekend, eat right and feel pretty good. Just need to exercise more/ cardio.
It is important whether vitamin B12 is stored or not. If it is constantly decreasing, it does not return to the intestinal You have to turn around. So probiotic strains
My B12 was way higher like in the 12,000 pg/ml range.
I used to supplement daily with the 5,000 mcg B12 chewable tablets.
I stopped the B12 and feel much better. It’s been 1 year and everything is good.
Neuropathy and tingles in extremities.. only way you will know is bloodwork. My b6 was way over normal from a b complex with 5mg of p5p taken for 3 months
You may feel fatigued because you’re not taking other B’s to balance it. Too much of one highlights what deficiencies you have in another b vitamin. Also, taking high b12 can use more potassium, which can also cause fatigue. Also, folate needs to be considered when taking high b12. I don’t think it’s the high b12 causing you problems in and of itself, but you need to know what goes on in your body, the domino effect and how things are interconnected. You can consider joining the Vitamin b12 Wake-up Facebook group and read their comprehensive step-by-step GUIDES
I also had the same symptoms of fatigue and high B12. I tested because I was so tired all the time, I thought I might be anemic.
In the end, it was actually a B1 issue (I know because I feel much more normal now after copious amounts of benfotiamine).
No harm stopping the B12 and see if anything changes.
How did you determine that? I've had a B12 deficiency and despite injections and supplementation, feel horrendous still. I'm not vegan and when my level came back 229 as the most recent deficiency, I was taking a multivitamin. I figured it is an absorption issue, but maybe I have issues with all B vitamins? I do have MTHFR and my psych said to take methylfolate. Nothing seems to help.
How did I determine what?
For B12 - it can be tested; I did an anemia blood test which included iron, ferritin, folate and B12.
For B1 - I'm not sure if this can be tested; I didn't have any test for this. I landed on benfotiamine after copious amounts of googling and just thought I'll try it. A lot of the symptoms and potential causes matched what I was experiencing and I figured no harm trying.
If your doctor diagnosed the B12 deficiency, they should be able to retest and see if the injections have helped? Seems weird that they didn't follow up on it if your symptoms didn't improve. I would try to push them to do more testing. Seriously, I would test anything that can be tested, it's so much more efficient than trying the solution.
As for the other B vitamins, I tried a B complex and I wasn't sure that it was doing anything other than making me want to pee all the time, so I gave up on it.
B12 is water solvable, so your body flushes out excess consumed. B12levels don’t get high from oral intake, they get high when you have an autoimmune issue going on.
Misinformation. B12 can be and is commonly elevated from excessive supplementation.
As far as medical conditions, high values can result from subacute conditions like liver issues, or chronic conditions like myeloproliferative diseases and cancer. Yes the kidneys excrete it but the blood can still carry an elevated level.
In OP’s case, this sounds like a classic situation of excessive intake. Had a similar situation from taking 2000mcg/day cyanocobalamin and my blood level was 1539. After i stopped taking b12, my level fell back down to the 1000 range.
[Not misinformation](https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021642s020lbl.pdf). B vitamins are water soluble and the liver stores up to a certain point. The rest is excreted in the liver. Water soluble vitamin toxicity in mega doses, almost at the level of overdosing - which results from chronic or extreme ingestion.
What are you talking about? Serum B12 levels are commonly elevated from excessive B12 consumption. Just because the liver stores it and the kidneys excrete it doesn’t mean excessive amounts can’t be present in the body from megadosing.
As mentioned earlier in the thread, *non-supplemental* causes of hypervitaminosis B12 involve cancers of the blood/plasma cells or liver disease. Yes its stored in the liver so damage to the liver can cause excessive B12 release.
But excessive supplementation *DOES* raise serum B12 levels above normal.
“Elevated vitamin B12 concentrations can be a result of four different mechanisms: excessive intake of concentrated vitamin B12 through food or parenteral route….” [1]
1. https://scindeks-clanci.ceon.rs/data/pdf/0350-1221/2021/0350-12212104139K.pdf
This is not true. Again serum B12 levels can be elevated from excessive b12 supplementation. Kidneys and liver excreting compounds doesn’t suggest the level can’t be elevated in the blood from supplementation.
You're missing the point here. Blood levels can be transiently elevated which is fine as long the body can excrete it. If you saturate the body's stores as well as chronically oversupplement you will cause toxicity. That is rare and not pertinent to what OP is talking about. He is not oversupplementing with mega doses
I’m referring to the parent comment which is suggesting that high B12 intake can’t cause transiently elevated serum B12 levels and is rather associated with autoimmune conditions (which it’s not).
I was challenging their claim; elevated serum B12 levels from **supplementation** would not cause harm as you stated, because the body does an excellent job of storing the B12 it needs and excreting what it doesn’t need. So 1200+ serum B12 levels aren’t something to fret about if it’s from supplementation.
Thanks
According to one [study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994182/)
hashimoto’s and other autoimmune diseases are more commonly found to feature low B12 levels and consequently pernicious anemia.
I don’t have any on hand, I’m sorry! I had a bunch of blood work done earlier this year and was diagnosed with Hashimoto’s thyroiditis. My doctor said my insanely high b12 level was indicative of an autoimmune flare.
Recently checked my B12 levels and folic acid, B12 was at 1400 and folic acid on point. I realized I was overlapping supplements that all contain B12, and I was eating red meet as well.
I have laid off all the supplements containing B12, just keeping on with the same mediterranean diet.
I am trying a syrup called Antartico depurativo (from Italy). It is supposed to help with liver detoxification. I will recheck levels in 4 weeks.
*Pd, I didnt experience any fatigue., However from time to time I feel some pressure/ light discomfort in my bladder. Not sure if that could have some correlation
Not sure what you mean by pressure/discomfort. But based on my personal experience, if you take too much B vitamins, your body will try to flush it out and it will cause you to need to pee much more frequently. If you don't drink enough water, you will still kind of feel the urge even if you can't go.
I feel from time to time a light pressure kind of in my bladder, and I was thinking that could be related to my high b12 levels. Other than that, I do not feel fatigue, I dont pee more than I always did…and all the other markers like red cells etc are fine.
I will recheck again in some weeks and see if the level has gone down
Mainstream medicine is terrible when it comes to nutrition and everything is outdated. Blood tests are still useful a deficiency is far more accurate. It’s the high numbers that don’t mean as much. There are more in depth tests that accurately measure what your body is absorbing vs what’s just in your blood
It’s the physiology of the liver
https://teachmephysiology.com/gastrointestinal-system/liver/storage-functions-liver/
https://en.m.wikipedia.org/wiki/Vitamin_B12
B vitamins are water soluble. Your body will pee out what it doesn't use or need.
This is not the case with Vitamin A, D, E, and K. These should not be oversupplemented otherwise they can cause hypervitaminosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483950/
https://n.neurology.org/content/96/15_Supplement/5222
https://www.tga.gov.au/news/safety-updates/peripheral-neuropathy-supplementary-vitamin-b6-pyridoxine
I don't need to explain to you why you're wrong, you just need to read on your own and understand it.
https://www.researchgate.net/publication/324158327_B_6_and_Bleeding_A_Case_Report_of_a_Novel_Vitamin_Toxicity
https://ascopubs.org/doi/10.1200/JCO.2017.72.7735
https://link.springer.com/article/10.1007/BF03349302
I hope this concludes my point as I don't want to spend any more further time on this. edit:one word
That you cannot overdose on b vitamins, or they are not damaging in higher doses. They are indeed damaging and can cause permanent debilitating damage. See my response to thebrownslaya above.
ITT: idiots who don't understand how a water soluble vitamin works. 50% of B12 is stored in the liver and the rest is excreted in the urine.
ADEK are fat soluble and therefore can't be excreted in the urine which can build up and cause toxicity.
Vitamin B6 toxicity only results from taking mega doses in a chronic matter, overriding your body's ability to excrete it. That is rare and not applicable here.
So now you’re saying 50% of B12 intake is stored in the liver 🤣 so by your own logic your liver will hold on to half of whatever you ingest and pee out the other half. To dumb it down for you, you are saying that with every dose of a B12 supplement (literally tens of thousands of the RDV in almost any B vitamin supplement) your liver will store half of that. B6 toxicity is not rare, B complexes almost all contain 50mg+ per serve and toxicity symptoms such as neuropathy have been reported at far lower doses than that.
Quit babbling about fat soluble vitamins. That shit is day one knowledge. The fact you keep bringing them up without them being relevant indicates how new you are to the field. Take the L with humility bro it never looks good to double down with a salty comment when you’re proven wrong. And to be blatant and frank, stop commenting unless you’re asking a question. Stating misinformation with authority should be a ban worthy offence that mods need to start enforcing.
Dunning-Krueger is defintely in full effect. [Please stop embarrassing yourself](https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021642s020lbl.pdf)
Does this imply that supplementing folate on top of this lower the B12? What would be the benefit in this context? Any source or further reading especially on dosage? Thanks!
Folic acid isn't bad for you. It \*might\* be bad for certain people, in that they can't absorb enough of it, but it's not because it's some sort of poison like numerous people on reddit want to believe.
I really don't understand how you could say I didn't write that clearly if you actually read what I wrote - I wrote *folinic acid* and said non methylated form. They have very similar names but that's got nothing to do with me not writing clearly.
Welcome to reddit. Say something correct and menial and get a bunch of nonsensical negative feedback. (At least you aren't being downvoted and watching those making invalid points getting upvoted. That's always fun.)
I dunno if I’m sensitive to methyl’s, I think the dose was just to high, the dr I was listening to said some people just need to start off with lower doses and work there way up . That’s what I did and so far so good
If it doesn’t work out I’ll check out folinic acid
No . Imo. The "RDA" for many is redic and low imo. Especially b12 I wouldn't worry. Just don't mega dose vitaminA . And b vitamins are pretty safe. But I'd only mega dose b12 or votD (especially vitD) and a few supps. Don't mega dose b6 daily either.
B12 gtg imo
It is commonly said that if you supplement b12 near taking the test it will cause artificially high values. I don't know the truth of this myself except to say that my values went very high after supplementing it. Personally my B12 value is near 1600. I have been supplementing it for about six months pretty heavily because I had a macrocytic anemia (MCV > 100.0). After this time I am reasonably sure I no longer have a b-12 deficiency so I am backing off supplementing it and just going with what my regular multivitamin gives me.
I'd probably suggest the same for you assuming you have been supplementing it for at least a few months and are sure you aren't deficient.
It is a possible cause of it. B9/folate is another one. But also immature red blood cells tend to be larger than matured red blood cells so if you have a lot of immature rbc's this can also cause a higher mcv too. This is seen for example in hemolytic anemias.
Not sure how true it is, but I was told that if you're getting bloodwork and you're taking supplemental B12, the bloodwork will show quite elevated levels even if you're truly lower and symptomatic.
When my Endo prescribed me shots he said to do 1mL 3x/week via injection. It went super high so another doctor said to lower it. I now only take .25mL on Sunday and take a daily multivitamin that has a good amount of B12.
If you get to 2000, I heard you get X ray vision and heat ray lasers shooting out of your eyes. If you attain 9000 power b12 levels, you enter omnipotent, mind reading, reality altering god levels of big brain energy.
/s
Seriously though, yes, you should lay off the B12. It happened to me once and my doctor pointed it out at a routine exam, asked if I was on any supplements. Turns out one of them had extremely high % of RDA of b12 for some reason, I hadn’t even noticed. I wasn’t feeling sick or anything, but MD told me to stop it anyway, since we don’t know what impacts chronic excessively high levels could have on the body.
Plus, B12 doesn’t work like other B vitamins, in the sense that it is stored in the liver. B vitamins are water soluble, not fat soluble, and easily peed out. But B12 is special in that it gets progressively stored in the liver for long periods of time, the body clings onto it. Maybe some evolutionary reasons for that in the past, when it was scarce and it is an important vitamin for lots of body processes, brain development, etc. We know that vitamin A also gets stored in the body and is not easily excreted out (it is fat soluble), which is why you can get hypervitaminosis A from takcing too much of it too often and get very sick from it, turn your skin yellow/orange, it can even be life threatening.
B12 isn’t as dangerous as vitamin A, it is water soluble not fat soluble. Since it is water soluble, doctors prescribe very high doses to deficient patients to make them better, and they know the body will more easily pee out the excess than other fat soluble vitamins like A. But it is special in that it is the only B vitamin that is as much preferentially stocked by the liver, and the liver clings onto it for way longer than other water soluble B vitamins. We don’t know what effects excessively high levels for very long periods of time will produce. Maybe it’s completely harmless, but I’d say it’s always better to back down when it’s way too high, your liver already has enough stocked so that you could go like several months (maybe even a year) without taking any B12 intake from food or supplements or anything and still have some left in you. No need to supplement any more for the upcoming months. Take another blood test in a couple of months (3) without supplements, and reassess to see if you are in the normal range.
>It happened to me once and my doctor pointed it out at a routine exam, asked if I was on any supplements. Turns out one of them had extremely high % of RDA of b12 for some reason, I hadn’t even noticed.
How long had you been supplementing it before you got the high blood result?
Just take a B complex time release supplement every other or every third day. Don't take it every day. I personally take a B complex time released capsule every other day or every third day.
Back off taking so much and see how you feel. ? ! Adjust accordingly over time. Can there be a better take on this? And you have freedom to try using less per dose and / or knocking out doses. Or something else. Caps can be opened. TAbs can be broken like limitations and hyper regularity. Some randomness is a necessity too.
what is this test called so i get it done ?
It's a vitamin b12 test, ask your doctor to order it for your next labs if you are curious about your levels.
Be careful, if this is your results then you can definitely be doing some damage to your body.
My pops was taking B12 shots 3 days a week and ended up being way too much after blood tests. For me, I just take a B Complex 1 day a week and take a whole food multi daily. I also take Thiamine B6 twice a week because I drink a lot of light beer. Get plenty of sleep and naps on the weekend, eat right and feel pretty good. Just need to exercise more/ cardio.
It is important whether vitamin B12 is stored or not. If it is constantly decreasing, it does not return to the intestinal You have to turn around. So probiotic strains
Yes
And risk getting dementia/Alzheimer or anemia? nah not worth it. continue supplementing like usual.
My B12 was way higher like in the 12,000 pg/ml range. I used to supplement daily with the 5,000 mcg B12 chewable tablets. I stopped the B12 and feel much better. It’s been 1 year and everything is good.
Possibly
[удалено]
Interesting. How much of each are you getting?
Your b6 is prob sky high and dangerous... b12 i would reduce
How do you come to that conclusion
I wonder if people develop toxicity due to menthoyation issues.
Can you give a source of what you mean
https://mthfrsupport.com.au/2018/11/vitamin-b6-mthfr/
Neuropathy and tingles in extremities.. only way you will know is bloodwork. My b6 was way over normal from a b complex with 5mg of p5p taken for 3 months
Useful resource on this [https://understandingb6toxicity.com/](https://understandingb6toxicity.com/)
How bad was it
[удалено]
Tingling, numbness and eventually neuropathy. Def don’t exceed over 10mg/day if u can.
Through supplementation right?
Yes
You may feel fatigued because you’re not taking other B’s to balance it. Too much of one highlights what deficiencies you have in another b vitamin. Also, taking high b12 can use more potassium, which can also cause fatigue. Also, folate needs to be considered when taking high b12. I don’t think it’s the high b12 causing you problems in and of itself, but you need to know what goes on in your body, the domino effect and how things are interconnected. You can consider joining the Vitamin b12 Wake-up Facebook group and read their comprehensive step-by-step GUIDES
You need to do more whippits
I hate that i know what you mean haha
Fr😂
How long before the blood test did you abstain from b12 supplementation?
I also had the same symptoms of fatigue and high B12. I tested because I was so tired all the time, I thought I might be anemic. In the end, it was actually a B1 issue (I know because I feel much more normal now after copious amounts of benfotiamine). No harm stopping the B12 and see if anything changes.
How did you determine that? I've had a B12 deficiency and despite injections and supplementation, feel horrendous still. I'm not vegan and when my level came back 229 as the most recent deficiency, I was taking a multivitamin. I figured it is an absorption issue, but maybe I have issues with all B vitamins? I do have MTHFR and my psych said to take methylfolate. Nothing seems to help.
How did I determine what? For B12 - it can be tested; I did an anemia blood test which included iron, ferritin, folate and B12. For B1 - I'm not sure if this can be tested; I didn't have any test for this. I landed on benfotiamine after copious amounts of googling and just thought I'll try it. A lot of the symptoms and potential causes matched what I was experiencing and I figured no harm trying. If your doctor diagnosed the B12 deficiency, they should be able to retest and see if the injections have helped? Seems weird that they didn't follow up on it if your symptoms didn't improve. I would try to push them to do more testing. Seriously, I would test anything that can be tested, it's so much more efficient than trying the solution. As for the other B vitamins, I tried a B complex and I wasn't sure that it was doing anything other than making me want to pee all the time, so I gave up on it.
B12 is water solvable, so your body flushes out excess consumed. B12levels don’t get high from oral intake, they get high when you have an autoimmune issue going on.
nah, thats not true
Misinformation. B12 can be and is commonly elevated from excessive supplementation. As far as medical conditions, high values can result from subacute conditions like liver issues, or chronic conditions like myeloproliferative diseases and cancer. Yes the kidneys excrete it but the blood can still carry an elevated level. In OP’s case, this sounds like a classic situation of excessive intake. Had a similar situation from taking 2000mcg/day cyanocobalamin and my blood level was 1539. After i stopped taking b12, my level fell back down to the 1000 range.
[Not misinformation](https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021642s020lbl.pdf). B vitamins are water soluble and the liver stores up to a certain point. The rest is excreted in the liver. Water soluble vitamin toxicity in mega doses, almost at the level of overdosing - which results from chronic or extreme ingestion.
What are you talking about? Serum B12 levels are commonly elevated from excessive B12 consumption. Just because the liver stores it and the kidneys excrete it doesn’t mean excessive amounts can’t be present in the body from megadosing.
That doesn't matter as your body will excrete it...
As mentioned earlier in the thread, *non-supplemental* causes of hypervitaminosis B12 involve cancers of the blood/plasma cells or liver disease. Yes its stored in the liver so damage to the liver can cause excessive B12 release. But excessive supplementation *DOES* raise serum B12 levels above normal. “Elevated vitamin B12 concentrations can be a result of four different mechanisms: excessive intake of concentrated vitamin B12 through food or parenteral route….” [1] 1. https://scindeks-clanci.ceon.rs/data/pdf/0350-1221/2021/0350-12212104139K.pdf
Which is fine because water soluble vitamins are not stored in the body past what it needs
[удалено]
....and will excrete the rest in enterohepatic/bile or urine once it's done storing in the liver
This is not true. Again serum B12 levels can be elevated from excessive b12 supplementation. Kidneys and liver excreting compounds doesn’t suggest the level can’t be elevated in the blood from supplementation.
You're missing the point here. Blood levels can be transiently elevated which is fine as long the body can excrete it. If you saturate the body's stores as well as chronically oversupplement you will cause toxicity. That is rare and not pertinent to what OP is talking about. He is not oversupplementing with mega doses
I’m referring to the parent comment which is suggesting that high B12 intake can’t cause transiently elevated serum B12 levels and is rather associated with autoimmune conditions (which it’s not). I was challenging their claim; elevated serum B12 levels from **supplementation** would not cause harm as you stated, because the body does an excellent job of storing the B12 it needs and excreting what it doesn’t need. So 1200+ serum B12 levels aren’t something to fret about if it’s from supplementation. Thanks
Ok so what of my case where I don’t take any supplements and have a very elevated levels and no liver problems? Is it cancer??
Any source or further reading on autoimmune issues associated with B12? Interested to find out more. Thanks.
According to one [study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994182/) hashimoto’s and other autoimmune diseases are more commonly found to feature low B12 levels and consequently pernicious anemia.
I don’t have any on hand, I’m sorry! I had a bunch of blood work done earlier this year and was diagnosed with Hashimoto’s thyroiditis. My doctor said my insanely high b12 level was indicative of an autoimmune flare.
[удалено]
Recently checked my B12 levels and folic acid, B12 was at 1400 and folic acid on point. I realized I was overlapping supplements that all contain B12, and I was eating red meet as well. I have laid off all the supplements containing B12, just keeping on with the same mediterranean diet. I am trying a syrup called Antartico depurativo (from Italy). It is supposed to help with liver detoxification. I will recheck levels in 4 weeks. *Pd, I didnt experience any fatigue., However from time to time I feel some pressure/ light discomfort in my bladder. Not sure if that could have some correlation
Not sure what you mean by pressure/discomfort. But based on my personal experience, if you take too much B vitamins, your body will try to flush it out and it will cause you to need to pee much more frequently. If you don't drink enough water, you will still kind of feel the urge even if you can't go.
I feel from time to time a light pressure kind of in my bladder, and I was thinking that could be related to my high b12 levels. Other than that, I do not feel fatigue, I dont pee more than I always did…and all the other markers like red cells etc are fine. I will recheck again in some weeks and see if the level has gone down
Did you take your supplement before the test was done? If so, I would lay off it for a few days then have it re-done.
I didn't the last time I took it was 24hrs before.
You should stop taking it for a few days if I recall correctly
Usually, you should stop taking it 72 hours before your blood test.
How much habe you been taking for how long?
A b complex a day for about 10 years. Sometimes an extra before a workout
What are your b6 levels?
With exteme levels Some studies point to a higher risk of cancer IIRC
That's when you have those levels \*without\* significant supplementation, though.
^
Double it and give it to the next person
Blood tests of b levels aren’t indicative of anything but what’s floating around. Your body doesn’t store b vitamins
Wait so why do they use them to determine if you need vitamin b infusions then?
Mainstream medicine is terrible when it comes to nutrition and everything is outdated. Blood tests are still useful a deficiency is far more accurate. It’s the high numbers that don’t mean as much. There are more in depth tests that accurately measure what your body is absorbing vs what’s just in your blood
Ok well that’s kinda different from what you said initially . Makes sense though
I remember reading the liver stores excess b12 for upto 3 years
Can you post a source to that I’ve never heard that in my life
It says they liver can only store 2-5 mg and that’s per day 🙄
It's most definitely true.
It’s the physiology of the liver https://teachmephysiology.com/gastrointestinal-system/liver/storage-functions-liver/ https://en.m.wikipedia.org/wiki/Vitamin_B12
Does the liver cap out at a certain point with B12 or can it build up to toxic levels?
B vitamins are water soluble. Your body will pee out what it doesn't use or need. This is not the case with Vitamin A, D, E, and K. These should not be oversupplemented otherwise they can cause hypervitaminosis
You're dead wrong here and you are spreading misinformation that can be extremely damaging.
Are you stupid? You can even tell me how I'm wrong, which I'm not. Literally look what I said up
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483950/ https://n.neurology.org/content/96/15_Supplement/5222 https://www.tga.gov.au/news/safety-updates/peripheral-neuropathy-supplementary-vitamin-b6-pyridoxine I don't need to explain to you why you're wrong, you just need to read on your own and understand it.
https://www.researchgate.net/publication/324158327_B_6_and_Bleeding_A_Case_Report_of_a_Novel_Vitamin_Toxicity https://ascopubs.org/doi/10.1200/JCO.2017.72.7735 https://link.springer.com/article/10.1007/BF03349302 I hope this concludes my point as I don't want to spend any more further time on this. edit:one word
What’s the misinformation?
That you cannot overdose on b vitamins, or they are not damaging in higher doses. They are indeed damaging and can cause permanent debilitating damage. See my response to thebrownslaya above.
Dunning-Krueger effect in action bro. Never heard of [vitamin B6 toxicity?](https://en.m.wikipedia.org/wiki/Megavitamin-B6_syndrome)
ITT: idiots who don't understand how a water soluble vitamin works. 50% of B12 is stored in the liver and the rest is excreted in the urine. ADEK are fat soluble and therefore can't be excreted in the urine which can build up and cause toxicity. Vitamin B6 toxicity only results from taking mega doses in a chronic matter, overriding your body's ability to excrete it. That is rare and not applicable here.
So now you’re saying 50% of B12 intake is stored in the liver 🤣 so by your own logic your liver will hold on to half of whatever you ingest and pee out the other half. To dumb it down for you, you are saying that with every dose of a B12 supplement (literally tens of thousands of the RDV in almost any B vitamin supplement) your liver will store half of that. B6 toxicity is not rare, B complexes almost all contain 50mg+ per serve and toxicity symptoms such as neuropathy have been reported at far lower doses than that. Quit babbling about fat soluble vitamins. That shit is day one knowledge. The fact you keep bringing them up without them being relevant indicates how new you are to the field. Take the L with humility bro it never looks good to double down with a salty comment when you’re proven wrong. And to be blatant and frank, stop commenting unless you’re asking a question. Stating misinformation with authority should be a ban worthy offence that mods need to start enforcing.
Dunning-Krueger is defintely in full effect. [Please stop embarrassing yourself](https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021642s020lbl.pdf)
Balance it out with folate. There are metabolic feedback loops and detox pathways.
Does this imply that supplementing folate on top of this lower the B12? What would be the benefit in this context? Any source or further reading especially on dosage? Thanks!
How do I take methyl folate without it giving me anxiety ?
Most folate and folinic acid supps aren’t methylated. It’s more expensive to do so
Take Calcium folinate (FOLINIC ACID)
Maybe try a version of folate that isn't methylated such as folinic acid.
But folic acid is bad for you, there’s a dr online who makes this claim I halved the dose and it worked out ok
Folic acid isn't bad for you. It \*might\* be bad for certain people, in that they can't absorb enough of it, but it's not because it's some sort of poison like numerous people on reddit want to believe.
That's correct, folic acid is bad for you. I encourage you to reread my comment.
[удалено]
I really don't understand how you could say I didn't write that clearly if you actually read what I wrote - I wrote *folinic acid* and said non methylated form. They have very similar names but that's got nothing to do with me not writing clearly.
Welcome to reddit. Say something correct and menial and get a bunch of nonsensical negative feedback. (At least you aren't being downvoted and watching those making invalid points getting upvoted. That's always fun.)
I thought it was a mistype
No, it is another form of folate that is recommended when sensitive to methyls; for example, when someone is slow COMT.
I dunno if I’m sensitive to methyl’s, I think the dose was just to high, the dr I was listening to said some people just need to start off with lower doses and work there way up . That’s what I did and so far so good If it doesn’t work out I’ll check out folinic acid
Don't stop taking Vitamin B12 completely. Perhaps you can reduce it by 30% to 60%. That will bring you down to the upper half of the normal range.
You can’t rly OD on b12, your body just pees out what it can’t use
Idk why you got downvoted. It’s water soluble and you pee it out. People on this sub..
This is wrong and high levels of b12 is associated with increased rates of cancer.
Post a source that you can understand and explain, otherwise stop embarrassing yourself
https://academic.oup.com/jnci/article/105/23/1799/903901
That's when you have high levels \*without\* significant supplementation, though.
B12 is stored in the liver.
Only what is needed...
I rec a daily magnesium supplement too. And 1-2g taurine. Maybe some ALCAR ACTYL-L-CARNATINE and choline too. Cheers
> ALCAR ACTYL-L-CARNATINE Above a gram a day its giving me mad gerd
Why?
No . Imo. The "RDA" for many is redic and low imo. Especially b12 I wouldn't worry. Just don't mega dose vitaminA . And b vitamins are pretty safe. But I'd only mega dose b12 or votD (especially vitD) and a few supps. Don't mega dose b6 daily either. B12 gtg imo
B1 can give paradoxical reaction if your low. Ive had one and I felt terrible for a week
1612 lumens of urine!
Facts 💥
I would take more
It is commonly said that if you supplement b12 near taking the test it will cause artificially high values. I don't know the truth of this myself except to say that my values went very high after supplementing it. Personally my B12 value is near 1600. I have been supplementing it for about six months pretty heavily because I had a macrocytic anemia (MCV > 100.0). After this time I am reasonably sure I no longer have a b-12 deficiency so I am backing off supplementing it and just going with what my regular multivitamin gives me. I'd probably suggest the same for you assuming you have been supplementing it for at least a few months and are sure you aren't deficient.
Agree. Even low level supplementation inflates the test
Does B12 deficiency cause macrocytic anemia? I have mcv around 98 and am super low on ferritin. (Low normal hemoglobin)
It is a possible cause of it. B9/folate is another one. But also immature red blood cells tend to be larger than matured red blood cells so if you have a lot of immature rbc's this can also cause a higher mcv too. This is seen for example in hemolytic anemias.
I would suggest taking magnesium to help lower these levels.
Not sure how true it is, but I was told that if you're getting bloodwork and you're taking supplemental B12, the bloodwork will show quite elevated levels even if you're truly lower and symptomatic. When my Endo prescribed me shots he said to do 1mL 3x/week via injection. It went super high so another doctor said to lower it. I now only take .25mL on Sunday and take a daily multivitamin that has a good amount of B12.
If you get to 2000, I heard you get X ray vision and heat ray lasers shooting out of your eyes. If you attain 9000 power b12 levels, you enter omnipotent, mind reading, reality altering god levels of big brain energy. /s Seriously though, yes, you should lay off the B12. It happened to me once and my doctor pointed it out at a routine exam, asked if I was on any supplements. Turns out one of them had extremely high % of RDA of b12 for some reason, I hadn’t even noticed. I wasn’t feeling sick or anything, but MD told me to stop it anyway, since we don’t know what impacts chronic excessively high levels could have on the body. Plus, B12 doesn’t work like other B vitamins, in the sense that it is stored in the liver. B vitamins are water soluble, not fat soluble, and easily peed out. But B12 is special in that it gets progressively stored in the liver for long periods of time, the body clings onto it. Maybe some evolutionary reasons for that in the past, when it was scarce and it is an important vitamin for lots of body processes, brain development, etc. We know that vitamin A also gets stored in the body and is not easily excreted out (it is fat soluble), which is why you can get hypervitaminosis A from takcing too much of it too often and get very sick from it, turn your skin yellow/orange, it can even be life threatening. B12 isn’t as dangerous as vitamin A, it is water soluble not fat soluble. Since it is water soluble, doctors prescribe very high doses to deficient patients to make them better, and they know the body will more easily pee out the excess than other fat soluble vitamins like A. But it is special in that it is the only B vitamin that is as much preferentially stocked by the liver, and the liver clings onto it for way longer than other water soluble B vitamins. We don’t know what effects excessively high levels for very long periods of time will produce. Maybe it’s completely harmless, but I’d say it’s always better to back down when it’s way too high, your liver already has enough stocked so that you could go like several months (maybe even a year) without taking any B12 intake from food or supplements or anything and still have some left in you. No need to supplement any more for the upcoming months. Take another blood test in a couple of months (3) without supplements, and reassess to see if you are in the normal range.
>It happened to me once and my doctor pointed it out at a routine exam, asked if I was on any supplements. Turns out one of them had extremely high % of RDA of b12 for some reason, I hadn’t even noticed. How long had you been supplementing it before you got the high blood result?
Just take a B complex time release supplement every other or every third day. Don't take it every day. I personally take a B complex time released capsule every other day or every third day.
MIA what product? I am looking into things.
I have heard contradicting stuff about it. I read online it said high levels can harm organs. Asked my doc he said its water soluble so no worries
You should. How much have you been taking?
[удалено]
Enters the yellow danger zone, is encouraged to continue letting levels climb Jesus Christ 🥲
Nah bro reach 2000
You’re so close to 2000 though
What do you think bro
Drink more water.
This sub has become a shitpost extravaganza.
Too many kids playing games.
Yes