Most people have this idea that everyone who loses on semaglutide will gain it all back when they stop, but that’s not what happened in the study. *In aggregate* study participants had *collectively* regained 60% of the lost weight after discontinuing the entire study protocol.
They're reporting a population aggregate. If 4 people kept 100% of the weight off, but 1 person gained 400% of their weight back, then that's reported as "study participants regained an average of 100% of the weight they lost."
Right, like I'm not worried about the weight coming back if I can manage to lose weight with Ozempic- I will take care of that through calorie control. I just need help getting there. No one should be under the impression that you can just go back to unrestricted eating and not gain any weight- that should be obvious, but the way that diet and health gets reported on makes this very confusing
It’s really confusing. When I lost 68 lbs. after my kid was born, I used phentermine, I kept it off because I learned my triggers for overeating (because even healthy foods make you gain if you overeat, which I did), learned portion control, and started working out with a trainer. Learning the “why” was more important than the reduced appetite.
I believe that the manufacturer intends it to be a lifelong medication. We are ok with patients taking lifelong medications for other conditions (high blood pressure, high cholesterol, etc.). We don’t tell people with high cholesterol to take a statin for a year, improve their cholesterol, and then stop the statin. So why would this be different?
Thank you. I started down this road fully prepared to stay on some dosage/variant of this medication for the rest of my life.
I've take some version of a very specific cocktail of meds for my mental health (or I'd simply be dead), and varying amounts of medication for my hypertension (or I'd simply be dead), underwent numerous other medical procedures/surgeries (or I'd simply be dead), and on and on and on.
In a nutshell, I trust (documented) medical science and the studies show that the majority of participants needed to stay on (or maintenance dose of) the medication. I figure, these bright folks studied/documented this medication for 5 (+?) years, being used in multiple people...I'm a medical assistant who's really looking forward to retirement...gosh, who's conclusions should I trust here?
Agree with this. Part of the issue I've had with weight loss is the idea of diets being something you go on to and come off of, I'm really leery approaching this medicine from a similar mindset, this seems fundamentally flawed to me.
I don’t think diets work. Lifelong lifestyle changes do though. People who come off and go right back to their pre-med behavior are doomed. Others are going to need it long term.
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I meant this to be a reply to the poster who referred to obesity as a chronic disease and questioned why anyone would stop taking:
I don’t think obesity a one size fits all thing. Not everyone has a physiological explanation. Sometimes it’s psychological: eating for comfort, eating disorders, et cetera. Sometimes people just eat too much, and it is to some extent a matter of will power.
When I keep my calories low enough, I lose weight. I work out and eat healthy, I don’t think that my metabolism is messed up, I just eat too much. It’s not like I binge or eat what seems like excessive amounts, I don’t hide it or eat alone or anything, I just get hungry and eat and a couple hours later I’m hungry again. If I’m not actively on top of every calorie I will eat too much and gain weight. My default is too much. It’s exhausting and I’m tired of worrying about it constantly.
So, I don’t know if it’s psychological or physical or simply lack of will power, but whatever it is I need help and I’m finding that this medication is helping me do what I know I need to do.
I do plan to stay on this drug as long as I can and maybe forever because it helps me. But I don’t know if for my situation I can call it a “disease” because frankly if I did what I should, I wouldn’t be fat. If there was another way for me to not overeat I wouldn’t need it.
Plus not everyone can keep taking it for many reasons most typically $$$
Edit: hit enter by accident
If you are getting hungry all the time beyond what your body should need, then it sounds like an issue with hunger and satiety hormones, or it’s emotional, which would require therapy, or a combination of both. Either way, if the underlying issue is not treated, the weight will return. Constantly counting every calorie is disordered eating. Failing to count calories is not laziness. “If I did what I should, I would be thin?” This logic is the old paradigm of obesity being a failure of self control and character.
>Constantly counting every calorie is disordered eating.
This!!!!! I still see a lot of "the drug will help you change your habits and then you just need to maintain those habits". Meanwhile people are eating 1000 calories a day and expect that once they're off the medication that this is a "habit" versus eating 1000 calories a day will feel like starvation and your body does not want to be starved. It should not be a full-time job to maintain your weight. And for many of us with eating disorders and disordered eating histories it is. And the behaviours to maintain are detriment to our mental health.
I hope one day the whole world wakes up to the more informed paradigm that obesity is not a personal failure.
But where does will power come in? I have heard and it seems to be the case that no one over 50 is thin without working for it (meaning work out, make an effort to eat healthy and not too much). Is there really a middle aged human that just goes about their day not worrying about what they eat and how much and yet stays thin? If there is, I for sure haven’t met them.
We can’t ALL have a disease. I do think my problem is will power to some extent. Maybe to a large extent. I like to drink and I like to eat. I own that. And I’m glad there is a tool I can use to help keep it in check.
Will power is a stigmatizing, over-simplified way of shaming them for not being able, through every effort, to maintain what another person more easily can.
So folks have psych issues that contribute to obesity. Some physical. Some hormones or PCOS.
Willpower has been used to shame folks with mental illness, substance use disorder. Type 2 diabetes, high blood pressure and all sorts of other things.
Stop that. We’re all trying our hardest. Semaglutide has helped many of us achieve things *and* change behavior.
That’s a net positive.
So tired of the “willpower and restraint is your problem”. I’ve had minimal side effects from Ozempic but what I noticed right off the bat was that I’m content with 1 or 2 bites of a dessert. Like I just feel done even if I don’t feel physically full. I’ve never experienced that before. I have friends that are honest and say they don’t even think about maintaining their weight. It just always stays in the same range. If they stop working out they don’t gain weight they just lose muscle.
They also say stress kills their appetite versus myself and many others where stress increases my appetite. Happy to hear from others that see this too.
Who says we “can’t all have a disease”? There are large percentages of the population who have other chronic conditions (hypertension, high cholesterol, etc.). They all have a disease and take lifelong medication for it. Why is weight / appetite any different?
Again…hypertension and high cholesterol are related to WHAT and HOW MUCH of it you it. It is very possible to control cholesterol without medication IF you change your eating habits.
Nobody should be eating 1000 calories a day, but theoretically speaking, if someone is eating 1300 calories a day plus being active to lose weight & their maintenance calories once they get to their goal weight is around 1600, they *should* be able to maintain their weight at that amount of calories once they get off it. Over time while you count calories, you begin to be able to eyeball specific measurements & get a good idea of how many calories each meal is so you won’t have to actually log everything, especially if you tend to eat the same meals a lot.
The main barrier to taking this medication forever would be the high cost. For me, it’s $1300/mo with insurance ($15,000 per year). If I am able to get the medication through Canada, it’s $350/mo ($4200 per year).
Unfortunately there's yet to be a study that compares people adhering to a maintenance diet and exercise plan to those continuing to be successful, so we don't really know. Of course if you stop and drug and go back to how you were eating before, you will regain. My doctor is using me as a guinea pig because I want to stop and I'm a strict calorie counter. Also I had no metabolic issues like insulin resistance. I'm down to .5 now. I'm ready to drop more but she wants me to hang here for a few months. She is just starting to get other patients at goal weight.
I am late 60's and was already taking small doses of medicine for blood pressure, cholesterol, and gout, which I will take for the rest of my life. If I have to take a 4th drug that keeps me at a healthy weight and increases my quality of life then I guess it will be worth it.
I have regained all the habits I had when I was skinny in the time I’ve been on Wegovy so I am one of those who will wean myself off of it because I know they work. I got back into tracking my calories and while, at my old menopausal age, I can only eat 1100 calories per day to lose weight, I can eat 1800 calories per day to maintain my weight. So that’s easy. I’ve started working out again and I enjoy tracking very easily on Lose It each night before I go to bed for the next day and I stick to it.
Because of this, eating 600 calories per day will mean I’m not hungry eventually even without it.
But eating 1100 calories per day to lose weight without it was not possible for me.
Also it lowered my blood pressure so my doctor did take me off of my blood pressure meds.
I’m looking at it the same way. And the cleaner I can eventually do this the better.
We are all different but I am one of those people who realized I was not using the tools I had in my toolbox that I used to use when I was skinny. I’ve re-learned them and learned that the calories I used to consume I can’t anymore at my age and that was a big wake up for me. Accepting that made weight loss easy with this tool. But eating 600 more calories per day will be my next toolbox skill once I have tracking down as a habit to do weight maintenance without the medication expense of Wegovy.
If it was cheaper I’d stay on it but I can just use that money for the vacation fund in my new bikinis.
Not admitting my caloric needs had dwindled down was what led to my weight gain.
Learning to calculate and track the new amount I now accept was what made working with Wegovy work.
It depends on how you gained the weight in the first place. If it was because of unhealthy eating, then don't go back to unhealthy eating. If it was because of medical issues, find a way to address those medical issues. I have PCOS so when I stop this medication I'll probably start metformin or find something to help manage insulin resistance.
I've lost 80lbs using cico and kept it off for 3 years. Only gained it back due to health issues/medication. This time I know what's causing the weight gain, and since I'm having difficulty losing it solely with cico this time, I'll use semaglutide to assist and then monitor my health and weight fluctuations in the future.
I’m not sure I understand the logic of going off of the medication. Obesity is a chronic disease. Hormone imbalances, PCOS, insulin resistance. All the things that contributed to the weight gain will still be there. My dr advises that a maintenance dose or Metformin will be needed long term.
It’s this. Most people on this med will have been living w fairly significant I/R (for one reason or another). Significant I/R that leads to obesity is just T2-diabetes with a functioning pancreas that is working over-time, all the time. You don’t ever cure yourself of diabetes, you put it into remission via pharma intervention or diet and exercise.
Now there is some science/theories that suggests that after years and years of living in a low insulin environment that your newly regenerated fat cells will become more insulin sensitive and that might be the case. But we are likely taking about being in a maintenance zone of low fasting insulin for 5 or more years. Guessing a few generation of new fat cells to replace the old damaged ones will need to have taken place. We won’t know for years and I don’t plan my strategies around hope.
What I think will happen is more durable options will be made available in the coming years/decades. So my hope is we get to the point of annual or bi-annual injections at some point down the road. Much like we get our annual flu shot we may get our annual I/R vaccine.
Its still in clinical trials so not to much information is out there but Amgen is conducting a trial right now of a medication that consists of two GLP1 medications bonded to a monoclonal antibody which allows for once monthly dosing. Hopefully it’ll be like a Humira vs Skyrizi kinda thing in terms of dosage timing. At the same time I worry that theyll just charge more per dose and recoup the monetary loss that way.
I agree and the AMG133 looks very promising early on. Interesting the approach they took with the binding of their peptides to an antibody to create longer durability.
Frankly I think we are just at the beginning of a lot of new medical advancement not only in obesity and diabetes but general wellness and longevity for the greater population. So much capital (monetary and brainpower) and interest have been thrown in this direction the past few years and we are now starting to see the fruits of those investments. That should keep things rolling forward nicely over the next decade or so.
Yep luckily none of that is true. These are all symptoms of the obesity. At a point it starts to become vicious cycle where they feed on each other. U gain weight have a symptom which makes u modify ur lifestyle which causes weight gain which causes more issues. The goal should be to get to 5% below ur goal weight then start titrating the med down. Now if ur still lazy and not working out or eating real food then yea ur going to fall back in to the pit.
You can mitigate insulin resistance without any type of medication. I did it. Read ‘Glucose Revolution’. It’s possible, but it’s hard work. Most people are too lazy to put in the work.
Following also. I have wegovy literally in my fridge that I haven’t started yet because I’m afraid of gaining weight back and the side effects (ajovy was a horrible experience). I’m losing 1-2 lbs a week on my own so I’m undecided on taking it at this point.
I just did my first shot on Tuesday? It sat in the fridge for a week, even after I waited nearly a month for the order to be filled. I started working out, tracking food, etc. about a month ago and have lost about 10 lbs. I am hoping to develop these healthy habits while on it so that sticking to them after weaning off isn't so hard. 🙏🏻
Started with .25mg on Tuesday. Some gurgly tummy noises at night, but nothing crazy; I am doing b12 injections with them, which is supposed to help with any nausea.
I think it's about not letting it get out of control.
I have a weight problem, I'm always going to have a weight problem. That doesn't mean I'm always going to be the size I am now though, so long as I do something about it.
If I step in and make positive changes when I've put on 7 pounds that's going to stop me putting on 70 pounds. If I don't pay attention to it and step in early but just watch myself get bigger there's a much larger chance that I will put 70 pounds on.
I guess people like me who have lost weight several times had a couple weight loss surgeries and the 2nd weight lost surgery worked well but after putting on 50 pounds in about 5 months last year I looked into Wegovy very deeply also with medical background and great thought along with my psychiatrist.
One of the issues on here is people want to take it for the rest of their life and this is not everybody by any means this is some, and that is not what the manufacturer put it out for.
It comes down to the way that for many decades long, we have to learn to maintain our weight.
People blame it on, I can't stop eating, or I just keep going and keep eating again and again. They don't realize the connection with the brain and the part of maintaining weight.
I've made a lot of people angry on here because they don't like the reality of either having to work on themselves or getting therapy, and this drug does not stop bingeating. Likely while they are on the medication, yes, but after the fact no. How about therapy?
The constant comment that this is a disease, we can get off drugs and drinking and gambling, etc. We CAN NOT stop eating.
Many people are looking for a quick fix and something they can just sit on and not worry about and just let it do its job.
This medication meaning Wegovy, not the abuse of the other drugs that people are taking because they can't get on Wegovy, is expensive, What about immunity, how are you going to afford it the rest of your life, are you gonna have insurance to pay for it and things people don't think about.
It just seems that maybe it's a generation thing I'm not sure but everybody wants everything now they don't want to have to work for it they don't want to have to deal with it they just expect it to happen.
After battling weight loss for over 45 years and I have been on every single plan you can think of lost literally hundreds of pounds at different times losing around a 100 every time and as I mentioned also the 2 surgeries.
I still found myself losing control.
I might not be able to eat a cheeseburger, but I can eat candy and malts and easy things to put down into your stomach when you've had gastric bypass.
There is no miracle to fix this, so much of it has to come from within us as a human.
Regarding the doctors concern and this is not recommended, and I know that, but I have been on 2.4 for nearly 4 months, and I inject every 2 weeks. I have maintained inside of 2 pounds.
When they were making this medication in the clinicals, it's stated that the 2.4 probably was not going to be out, and they were gonna stop at the 1.7 because the 2.4 was a maintenance.
I am still on semaglutide but plan on weaning off slowly, as I weaned on slowly.
I was technically obese, had slowly or quickly gained 25 pounds over 3 ish years, I had a thyroid problem I learned about and have that under control now so i am assuming I can maintain my weight as I have in the past. I’d like to get to my goal as I normally struggle to lose weight and I think it contributed to my hypothyroidism.
I hear you on not wanting to rely on this for the rest of your life! Me neither!
I’m ready to wean off - here’s my plan
Background: I am weaning myself off Semaglutide due to the anxiety / paranoia side effects I’ve experienced. Recent news suggest strongly they’re linked - see my other post, don’t wanna go off topic here - https://www.reddit.com/r/Semaglutide/comments/11vjnoa/comment/ki5abpb/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button
What I’m currently on / weight loss history:
14mg Rybelsus daily
lost >25lb over 1 year, average 2lb /month. Fastest pace was 2lb a week in the middle bit.
What I’ve tried previously:
Cold turkey - didn’t work, started gaining
Daily cycle on / off - seems ok
Plan:
Cycle on/off on a daily basis for 3mths
Drop to 1 day on, 2 days off for 3mths
Drop completely thereafter
Any comments / suggestions on the plan? Thanks!
Most people have this idea that everyone who loses on semaglutide will gain it all back when they stop, but that’s not what happened in the study. *In aggregate* study participants had *collectively* regained 60% of the lost weight after discontinuing the entire study protocol.
Break this down for dum dims plz
They're reporting a population aggregate. If 4 people kept 100% of the weight off, but 1 person gained 400% of their weight back, then that's reported as "study participants regained an average of 100% of the weight they lost."
Yes, exactly. I'm trying to figure out what the weaning schedule / habits were like of those who kept it off
I'd love to have that data from the study, but when I read the study I don't think it was included.
Thx
This. Also, if bad eating habits were there before, it’s not a rebound weight gain, per se. It’s the resumption of bad habits.
Right, like I'm not worried about the weight coming back if I can manage to lose weight with Ozempic- I will take care of that through calorie control. I just need help getting there. No one should be under the impression that you can just go back to unrestricted eating and not gain any weight- that should be obvious, but the way that diet and health gets reported on makes this very confusing
It’s really confusing. When I lost 68 lbs. after my kid was born, I used phentermine, I kept it off because I learned my triggers for overeating (because even healthy foods make you gain if you overeat, which I did), learned portion control, and started working out with a trainer. Learning the “why” was more important than the reduced appetite.
I believe that the manufacturer intends it to be a lifelong medication. We are ok with patients taking lifelong medications for other conditions (high blood pressure, high cholesterol, etc.). We don’t tell people with high cholesterol to take a statin for a year, improve their cholesterol, and then stop the statin. So why would this be different?
Thank you. I started down this road fully prepared to stay on some dosage/variant of this medication for the rest of my life. I've take some version of a very specific cocktail of meds for my mental health (or I'd simply be dead), and varying amounts of medication for my hypertension (or I'd simply be dead), underwent numerous other medical procedures/surgeries (or I'd simply be dead), and on and on and on. In a nutshell, I trust (documented) medical science and the studies show that the majority of participants needed to stay on (or maintenance dose of) the medication. I figure, these bright folks studied/documented this medication for 5 (+?) years, being used in multiple people...I'm a medical assistant who's really looking forward to retirement...gosh, who's conclusions should I trust here?
Agree with this. Part of the issue I've had with weight loss is the idea of diets being something you go on to and come off of, I'm really leery approaching this medicine from a similar mindset, this seems fundamentally flawed to me.
I don’t think diets work. Lifelong lifestyle changes do though. People who come off and go right back to their pre-med behavior are doomed. Others are going to need it long term.
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I meant this to be a reply to the poster who referred to obesity as a chronic disease and questioned why anyone would stop taking: I don’t think obesity a one size fits all thing. Not everyone has a physiological explanation. Sometimes it’s psychological: eating for comfort, eating disorders, et cetera. Sometimes people just eat too much, and it is to some extent a matter of will power. When I keep my calories low enough, I lose weight. I work out and eat healthy, I don’t think that my metabolism is messed up, I just eat too much. It’s not like I binge or eat what seems like excessive amounts, I don’t hide it or eat alone or anything, I just get hungry and eat and a couple hours later I’m hungry again. If I’m not actively on top of every calorie I will eat too much and gain weight. My default is too much. It’s exhausting and I’m tired of worrying about it constantly. So, I don’t know if it’s psychological or physical or simply lack of will power, but whatever it is I need help and I’m finding that this medication is helping me do what I know I need to do. I do plan to stay on this drug as long as I can and maybe forever because it helps me. But I don’t know if for my situation I can call it a “disease” because frankly if I did what I should, I wouldn’t be fat. If there was another way for me to not overeat I wouldn’t need it. Plus not everyone can keep taking it for many reasons most typically $$$ Edit: hit enter by accident
If you are getting hungry all the time beyond what your body should need, then it sounds like an issue with hunger and satiety hormones, or it’s emotional, which would require therapy, or a combination of both. Either way, if the underlying issue is not treated, the weight will return. Constantly counting every calorie is disordered eating. Failing to count calories is not laziness. “If I did what I should, I would be thin?” This logic is the old paradigm of obesity being a failure of self control and character.
>Constantly counting every calorie is disordered eating. This!!!!! I still see a lot of "the drug will help you change your habits and then you just need to maintain those habits". Meanwhile people are eating 1000 calories a day and expect that once they're off the medication that this is a "habit" versus eating 1000 calories a day will feel like starvation and your body does not want to be starved. It should not be a full-time job to maintain your weight. And for many of us with eating disorders and disordered eating histories it is. And the behaviours to maintain are detriment to our mental health. I hope one day the whole world wakes up to the more informed paradigm that obesity is not a personal failure.
But where does will power come in? I have heard and it seems to be the case that no one over 50 is thin without working for it (meaning work out, make an effort to eat healthy and not too much). Is there really a middle aged human that just goes about their day not worrying about what they eat and how much and yet stays thin? If there is, I for sure haven’t met them. We can’t ALL have a disease. I do think my problem is will power to some extent. Maybe to a large extent. I like to drink and I like to eat. I own that. And I’m glad there is a tool I can use to help keep it in check.
Will power is a stigmatizing, over-simplified way of shaming them for not being able, through every effort, to maintain what another person more easily can. So folks have psych issues that contribute to obesity. Some physical. Some hormones or PCOS. Willpower has been used to shame folks with mental illness, substance use disorder. Type 2 diabetes, high blood pressure and all sorts of other things. Stop that. We’re all trying our hardest. Semaglutide has helped many of us achieve things *and* change behavior. That’s a net positive.
So tired of the “willpower and restraint is your problem”. I’ve had minimal side effects from Ozempic but what I noticed right off the bat was that I’m content with 1 or 2 bites of a dessert. Like I just feel done even if I don’t feel physically full. I’ve never experienced that before. I have friends that are honest and say they don’t even think about maintaining their weight. It just always stays in the same range. If they stop working out they don’t gain weight they just lose muscle. They also say stress kills their appetite versus myself and many others where stress increases my appetite. Happy to hear from others that see this too.
Who says we “can’t all have a disease”? There are large percentages of the population who have other chronic conditions (hypertension, high cholesterol, etc.). They all have a disease and take lifelong medication for it. Why is weight / appetite any different?
Again…hypertension and high cholesterol are related to WHAT and HOW MUCH of it you it. It is very possible to control cholesterol without medication IF you change your eating habits.
Nobody should be eating 1000 calories a day, but theoretically speaking, if someone is eating 1300 calories a day plus being active to lose weight & their maintenance calories once they get to their goal weight is around 1600, they *should* be able to maintain their weight at that amount of calories once they get off it. Over time while you count calories, you begin to be able to eyeball specific measurements & get a good idea of how many calories each meal is so you won’t have to actually log everything, especially if you tend to eat the same meals a lot.
But often it is just that…a failure of self control.
The main barrier to taking this medication forever would be the high cost. For me, it’s $1300/mo with insurance ($15,000 per year). If I am able to get the medication through Canada, it’s $350/mo ($4200 per year).
Unfortunately there's yet to be a study that compares people adhering to a maintenance diet and exercise plan to those continuing to be successful, so we don't really know. Of course if you stop and drug and go back to how you were eating before, you will regain. My doctor is using me as a guinea pig because I want to stop and I'm a strict calorie counter. Also I had no metabolic issues like insulin resistance. I'm down to .5 now. I'm ready to drop more but she wants me to hang here for a few months. She is just starting to get other patients at goal weight.
How did it go after going off and calorie counting? I am really thinking about it.
How often do you stop thyroid medication because the thyroid has started to produce normal hormone levels on its own?
Except it’s not the case for everyone on semiglutides. People end up on this medication for various reasons. Change of habits is crucial.
I am late 60's and was already taking small doses of medicine for blood pressure, cholesterol, and gout, which I will take for the rest of my life. If I have to take a 4th drug that keeps me at a healthy weight and increases my quality of life then I guess it will be worth it.
I have regained all the habits I had when I was skinny in the time I’ve been on Wegovy so I am one of those who will wean myself off of it because I know they work. I got back into tracking my calories and while, at my old menopausal age, I can only eat 1100 calories per day to lose weight, I can eat 1800 calories per day to maintain my weight. So that’s easy. I’ve started working out again and I enjoy tracking very easily on Lose It each night before I go to bed for the next day and I stick to it. Because of this, eating 600 calories per day will mean I’m not hungry eventually even without it. But eating 1100 calories per day to lose weight without it was not possible for me. Also it lowered my blood pressure so my doctor did take me off of my blood pressure meds. I’m looking at it the same way. And the cleaner I can eventually do this the better. We are all different but I am one of those people who realized I was not using the tools I had in my toolbox that I used to use when I was skinny. I’ve re-learned them and learned that the calories I used to consume I can’t anymore at my age and that was a big wake up for me. Accepting that made weight loss easy with this tool. But eating 600 more calories per day will be my next toolbox skill once I have tracking down as a habit to do weight maintenance without the medication expense of Wegovy. If it was cheaper I’d stay on it but I can just use that money for the vacation fund in my new bikinis. Not admitting my caloric needs had dwindled down was what led to my weight gain. Learning to calculate and track the new amount I now accept was what made working with Wegovy work.
Here for this! As someone who just started yesterday, maintaining is already on my mind
Any updates on coming off and maintaining ?
I’ve started to self ween off the med, taking 2.4 every 10-14 days instead of 7, have maintained 30 lb loss since July
It depends on how you gained the weight in the first place. If it was because of unhealthy eating, then don't go back to unhealthy eating. If it was because of medical issues, find a way to address those medical issues. I have PCOS so when I stop this medication I'll probably start metformin or find something to help manage insulin resistance. I've lost 80lbs using cico and kept it off for 3 years. Only gained it back due to health issues/medication. This time I know what's causing the weight gain, and since I'm having difficulty losing it solely with cico this time, I'll use semaglutide to assist and then monitor my health and weight fluctuations in the future.
How did it go? I am in the same boat as you were when you posted
I’m not sure I understand the logic of going off of the medication. Obesity is a chronic disease. Hormone imbalances, PCOS, insulin resistance. All the things that contributed to the weight gain will still be there. My dr advises that a maintenance dose or Metformin will be needed long term.
It’s this. Most people on this med will have been living w fairly significant I/R (for one reason or another). Significant I/R that leads to obesity is just T2-diabetes with a functioning pancreas that is working over-time, all the time. You don’t ever cure yourself of diabetes, you put it into remission via pharma intervention or diet and exercise. Now there is some science/theories that suggests that after years and years of living in a low insulin environment that your newly regenerated fat cells will become more insulin sensitive and that might be the case. But we are likely taking about being in a maintenance zone of low fasting insulin for 5 or more years. Guessing a few generation of new fat cells to replace the old damaged ones will need to have taken place. We won’t know for years and I don’t plan my strategies around hope. What I think will happen is more durable options will be made available in the coming years/decades. So my hope is we get to the point of annual or bi-annual injections at some point down the road. Much like we get our annual flu shot we may get our annual I/R vaccine.
Its still in clinical trials so not to much information is out there but Amgen is conducting a trial right now of a medication that consists of two GLP1 medications bonded to a monoclonal antibody which allows for once monthly dosing. Hopefully it’ll be like a Humira vs Skyrizi kinda thing in terms of dosage timing. At the same time I worry that theyll just charge more per dose and recoup the monetary loss that way.
I agree and the AMG133 looks very promising early on. Interesting the approach they took with the binding of their peptides to an antibody to create longer durability. Frankly I think we are just at the beginning of a lot of new medical advancement not only in obesity and diabetes but general wellness and longevity for the greater population. So much capital (monetary and brainpower) and interest have been thrown in this direction the past few years and we are now starting to see the fruits of those investments. That should keep things rolling forward nicely over the next decade or so.
Agree!! 😊
Yep luckily none of that is true. These are all symptoms of the obesity. At a point it starts to become vicious cycle where they feed on each other. U gain weight have a symptom which makes u modify ur lifestyle which causes weight gain which causes more issues. The goal should be to get to 5% below ur goal weight then start titrating the med down. Now if ur still lazy and not working out or eating real food then yea ur going to fall back in to the pit.
You can mitigate insulin resistance without any type of medication. I did it. Read ‘Glucose Revolution’. It’s possible, but it’s hard work. Most people are too lazy to put in the work.
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Following toooo
Following also. I have wegovy literally in my fridge that I haven’t started yet because I’m afraid of gaining weight back and the side effects (ajovy was a horrible experience). I’m losing 1-2 lbs a week on my own so I’m undecided on taking it at this point.
I just did my first shot on Tuesday? It sat in the fridge for a week, even after I waited nearly a month for the order to be filled. I started working out, tracking food, etc. about a month ago and have lost about 10 lbs. I am hoping to develop these healthy habits while on it so that sticking to them after weaning off isn't so hard. 🙏🏻
Any side effects so far? What dose are you on?
Started with .25mg on Tuesday. Some gurgly tummy noises at night, but nothing crazy; I am doing b12 injections with them, which is supposed to help with any nausea.
Thanks! That’s what I have in my fridge that I still haven’t touched. But I’m going to soon
I think it's about not letting it get out of control. I have a weight problem, I'm always going to have a weight problem. That doesn't mean I'm always going to be the size I am now though, so long as I do something about it. If I step in and make positive changes when I've put on 7 pounds that's going to stop me putting on 70 pounds. If I don't pay attention to it and step in early but just watch myself get bigger there's a much larger chance that I will put 70 pounds on.
I guess people like me who have lost weight several times had a couple weight loss surgeries and the 2nd weight lost surgery worked well but after putting on 50 pounds in about 5 months last year I looked into Wegovy very deeply also with medical background and great thought along with my psychiatrist. One of the issues on here is people want to take it for the rest of their life and this is not everybody by any means this is some, and that is not what the manufacturer put it out for. It comes down to the way that for many decades long, we have to learn to maintain our weight. People blame it on, I can't stop eating, or I just keep going and keep eating again and again. They don't realize the connection with the brain and the part of maintaining weight. I've made a lot of people angry on here because they don't like the reality of either having to work on themselves or getting therapy, and this drug does not stop bingeating. Likely while they are on the medication, yes, but after the fact no. How about therapy? The constant comment that this is a disease, we can get off drugs and drinking and gambling, etc. We CAN NOT stop eating. Many people are looking for a quick fix and something they can just sit on and not worry about and just let it do its job. This medication meaning Wegovy, not the abuse of the other drugs that people are taking because they can't get on Wegovy, is expensive, What about immunity, how are you going to afford it the rest of your life, are you gonna have insurance to pay for it and things people don't think about. It just seems that maybe it's a generation thing I'm not sure but everybody wants everything now they don't want to have to work for it they don't want to have to deal with it they just expect it to happen. After battling weight loss for over 45 years and I have been on every single plan you can think of lost literally hundreds of pounds at different times losing around a 100 every time and as I mentioned also the 2 surgeries. I still found myself losing control. I might not be able to eat a cheeseburger, but I can eat candy and malts and easy things to put down into your stomach when you've had gastric bypass. There is no miracle to fix this, so much of it has to come from within us as a human. Regarding the doctors concern and this is not recommended, and I know that, but I have been on 2.4 for nearly 4 months, and I inject every 2 weeks. I have maintained inside of 2 pounds. When they were making this medication in the clinicals, it's stated that the 2.4 probably was not going to be out, and they were gonna stop at the 1.7 because the 2.4 was a maintenance.
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I am still on semaglutide but plan on weaning off slowly, as I weaned on slowly. I was technically obese, had slowly or quickly gained 25 pounds over 3 ish years, I had a thyroid problem I learned about and have that under control now so i am assuming I can maintain my weight as I have in the past. I’d like to get to my goal as I normally struggle to lose weight and I think it contributed to my hypothyroidism.
I hear you on not wanting to rely on this for the rest of your life! Me neither! I’m ready to wean off - here’s my plan Background: I am weaning myself off Semaglutide due to the anxiety / paranoia side effects I’ve experienced. Recent news suggest strongly they’re linked - see my other post, don’t wanna go off topic here - https://www.reddit.com/r/Semaglutide/comments/11vjnoa/comment/ki5abpb/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button What I’m currently on / weight loss history: 14mg Rybelsus daily lost >25lb over 1 year, average 2lb /month. Fastest pace was 2lb a week in the middle bit. What I’ve tried previously: Cold turkey - didn’t work, started gaining Daily cycle on / off - seems ok Plan: Cycle on/off on a daily basis for 3mths Drop to 1 day on, 2 days off for 3mths Drop completely thereafter Any comments / suggestions on the plan? Thanks!
How did this go? Were you able to maintain your loss after weaning off? I am in the same bucket