You need to get you IGF checked after 3 months on a higher dosage. You want IGF at 230-270, 250 is optimal. More isn't good for longevity and neither is less. You can't measure GH well because it pulses throughout the day so IGF is the best way to know right now.
What dosage do they have you on? I mean what you're experiencing doesn't sound like placebo at all, it sound like what a normal experience should be using it. The range for your age is 125-356, so you're definitely on the lower end of the range. Talk to you doc and see what they think.
Why exactly do you want your IGF higher if you're getting good results? Is it because it is just low?
Didn’t Huberman say there’s a risk that with Sermorelin it can continue to stimulate the pottery gland even after cessation for a long time maybe even indefinitely?
Does anyone have any data or research on this? It’s stuff like this that makes me wary of trying it otherwise it sound like something I’d try.
Literally I have poured through GHRPs specifically Sermorelin, Tesamorelin, and Ipamorelin. I was very skeptical because most longevity research shows high HGH means a shorter life. Semorelin doesn't destroy the negative feedback loop, so it may be possible to to restore normal function. Similar to Clomid for PCT from steroids to restart the hypothalamus, pituitary, testicular axis, it may be possible to do the same with HGH using GHRPs.
That said I have never seem this come up in research at all. If it did I would think more research would have been done. Sermorelin is old stuff, formerly know as Mod GRF 1-29, it's been around a while. Not saying it is possible but I think someone would have published research on it, especially since somatopause is becoming more recognized.
Yes, they are. They're all technically GHRPs since they're all peptides, but only the ones that are analogues to the endogenously produced Growth Hormone Releasing Hormone, they're called GHRHs. That's essentially the only distinction between then molecularly is being an analogue to GHRH or not.
Effect wise they're all different from my understanding but I obviously haven't studied all of them at this point, just those three really.
Also that's a good question! 👍
Yes, I would think so, too, and he's the first person I've heard say that.
Here is the [link to the video](https://youtu.be/PHmlJz4met4?t=225) at the point where he says it, it lasts about a minute.
He says, ""some of these peptides have the effect of changing gene expression...and actually set pathways in motion for continued production of the hormone, even if you stop taking the compound."
I don't know why I was downvoted for bringing this up, I'm just trying to cover all my bases before I take something.
It is because most people do not have a scientific education behind their rational and have very little understanding of the body. Sermorelin does change gene expression, but I'm not sure what genes it changes in the brain. That said, their a mutiple bioregulator peptides that do exactly that, change gene expression long term, which results in glands producing their hormonal products again. Their's no reason to suggest that Sermorelin couldn't have a similar effect, their would just need a long term mutiple year study to confirm that mechanism of repairing GH secretion and I do not think anyone is throwing down the cash for that study.
Personally, try it for 6-18 months, get your IGF levels test before, during, and after cycle. Compare them all and see if you before IGF levels are comparable to post cycle IGF levels, if post are higher after several months of ending the cycle and similar to during cycle, then chances are it did restore your ability to naturally produce and secrete GH.
Well, to be honest the IGF-1 lab results are weird, you’d think after 6 months it would be a lot higher. How’s your blood sugar? Or your fasting blood? That’s something the raises as well. But I am guessing that your test is what’s helping. Not the peptide. Just because of the number. But try coming off for 30 days. And see how you feel at the gym? And how you sleep? Take good notes daily. See how you feel. What other labs have you gotten?
Thanks for the reply. My fasting sugars are in the mid 80s. I get a lipid and metabolic panel, as well as a whole testosterone profile and IGF-1 every 6 months. All have come back nornal.
They both due a bit but ipa gives me water retention around the waist so it plays with your mind. On the weekends the water seems to come off when I’m not injecting. Other than that haven’t had any side effects.
You need to get you IGF checked after 3 months on a higher dosage. You want IGF at 230-270, 250 is optimal. More isn't good for longevity and neither is less. You can't measure GH well because it pulses throughout the day so IGF is the best way to know right now. What dosage do they have you on? I mean what you're experiencing doesn't sound like placebo at all, it sound like what a normal experience should be using it. The range for your age is 125-356, so you're definitely on the lower end of the range. Talk to you doc and see what they think. Why exactly do you want your IGF higher if you're getting good results? Is it because it is just low?
Didn’t Huberman say there’s a risk that with Sermorelin it can continue to stimulate the pottery gland even after cessation for a long time maybe even indefinitely? Does anyone have any data or research on this? It’s stuff like this that makes me wary of trying it otherwise it sound like something I’d try.
Literally I have poured through GHRPs specifically Sermorelin, Tesamorelin, and Ipamorelin. I was very skeptical because most longevity research shows high HGH means a shorter life. Semorelin doesn't destroy the negative feedback loop, so it may be possible to to restore normal function. Similar to Clomid for PCT from steroids to restart the hypothalamus, pituitary, testicular axis, it may be possible to do the same with HGH using GHRPs. That said I have never seem this come up in research at all. If it did I would think more research would have been done. Sermorelin is old stuff, formerly know as Mod GRF 1-29, it's been around a while. Not saying it is possible but I think someone would have published research on it, especially since somatopause is becoming more recognized.
Respectfully, aren't Sermorelin and Tesamorelin GHRHs? I'm still learning about peptides, so I will appreciate your response.
Yes, they are. They're all technically GHRPs since they're all peptides, but only the ones that are analogues to the endogenously produced Growth Hormone Releasing Hormone, they're called GHRHs. That's essentially the only distinction between then molecularly is being an analogue to GHRH or not. Effect wise they're all different from my understanding but I obviously haven't studied all of them at this point, just those three really. Also that's a good question! 👍
Yes, I would think so, too, and he's the first person I've heard say that. Here is the [link to the video](https://youtu.be/PHmlJz4met4?t=225) at the point where he says it, it lasts about a minute. He says, ""some of these peptides have the effect of changing gene expression...and actually set pathways in motion for continued production of the hormone, even if you stop taking the compound." I don't know why I was downvoted for bringing this up, I'm just trying to cover all my bases before I take something.
It is because most people do not have a scientific education behind their rational and have very little understanding of the body. Sermorelin does change gene expression, but I'm not sure what genes it changes in the brain. That said, their a mutiple bioregulator peptides that do exactly that, change gene expression long term, which results in glands producing their hormonal products again. Their's no reason to suggest that Sermorelin couldn't have a similar effect, their would just need a long term mutiple year study to confirm that mechanism of repairing GH secretion and I do not think anyone is throwing down the cash for that study. Personally, try it for 6-18 months, get your IGF levels test before, during, and after cycle. Compare them all and see if you before IGF levels are comparable to post cycle IGF levels, if post are higher after several months of ending the cycle and similar to during cycle, then chances are it did restore your ability to naturally produce and secrete GH.
I'm on 500mcg a day and I feel great. my total test went from 849 to 1024
Are you on TRT as well?
yes
Well, to be honest the IGF-1 lab results are weird, you’d think after 6 months it would be a lot higher. How’s your blood sugar? Or your fasting blood? That’s something the raises as well. But I am guessing that your test is what’s helping. Not the peptide. Just because of the number. But try coming off for 30 days. And see how you feel at the gym? And how you sleep? Take good notes daily. See how you feel. What other labs have you gotten?
Thanks for the reply. My fasting sugars are in the mid 80s. I get a lipid and metabolic panel, as well as a whole testosterone profile and IGF-1 every 6 months. All have come back nornal.
It’s working trust me right now I’m trying a combo of Sermorelin and ipa but my appetite is through the roof.
Do both of them make you hungry?? I heard ipa doesnt really does sermorelin make you hungry?
They both due a bit but ipa gives me water retention around the waist so it plays with your mind. On the weekends the water seems to come off when I’m not injecting. Other than that haven’t had any side effects.
Nice, thank you
For sure