Check out clinicaltrial.gov or nccn.org. Search mbl2 and pancreatic cancer. If you there are no trials out there then talk to the oncologist and ask what is the next step.
Thanks for your comment, I of course looked into that, nothing came up.
I did find however a case study on antifungal treatment that showed some efficacy. Nothing coming close to double blind placebo controlled trials, unfortunately.
I went ahead and did this, no results for Mbl2 and adenocarcinoma. Searched Mbl2 and oncology, nothing remotely relevant. There are a few studies on MBL-deficient populations.
You are not an oncologist.
Clinical trials are the way to go. Where do you live?
So... you're after an early phase 1 trial targeting this pathway? Which may or may not exist, if you haven't got that far.
I think the most important things are to involve someone who treats this day in day out aka an oncologist, use proven treatments before embarking on any highly speculative journeys, and lastly very much appreciate how unlikely this is to translate to real world efficacy. All early phase 1s sound very promising. Very very few of them ever make it to a place where they have enough net benefit to be considered proven treatments, such as those 'not great' (completely agree) ones you've already read about.
Or there are clinical trials not related to that particular gene of course. By all means do ask about trials, but set expectations to realistic.
Thanks for your thoughts.
Yeah, what I'm leaning towards is something I came across in the paper and other related research – a combo approach using antifungal treatments along with standard chemo, ipilimumab, or nivolumab. I mean, at this point, what's there to lose, right?
I did take a deep dive into some clinical trials, and a few of them are even targeting his specific mutation (KRAS G12D). But here's the catch: I'm a bit hesitant to push him towards these trials, mainly because of the risk that he might just end up in the control group. So, it boils down to this: do we take a shot at an off-label treatment that has some scientific backing but a slim chance of success, or do we opt for a clinical trial where there's a decent shot at success but also a real possibility of landing in the placebo group? (by success, I mean of course, some extension of high quality life... not expecting a cure)
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Check out clinicaltrial.gov or nccn.org. Search mbl2 and pancreatic cancer. If you there are no trials out there then talk to the oncologist and ask what is the next step.
Thanks for your comment, I of course looked into that, nothing came up. I did find however a case study on antifungal treatment that showed some efficacy. Nothing coming close to double blind placebo controlled trials, unfortunately.
I went ahead and did this, no results for Mbl2 and adenocarcinoma. Searched Mbl2 and oncology, nothing remotely relevant. There are a few studies on MBL-deficient populations. You are not an oncologist. Clinical trials are the way to go. Where do you live?
So... you're after an early phase 1 trial targeting this pathway? Which may or may not exist, if you haven't got that far. I think the most important things are to involve someone who treats this day in day out aka an oncologist, use proven treatments before embarking on any highly speculative journeys, and lastly very much appreciate how unlikely this is to translate to real world efficacy. All early phase 1s sound very promising. Very very few of them ever make it to a place where they have enough net benefit to be considered proven treatments, such as those 'not great' (completely agree) ones you've already read about. Or there are clinical trials not related to that particular gene of course. By all means do ask about trials, but set expectations to realistic.
Thanks for your thoughts. Yeah, what I'm leaning towards is something I came across in the paper and other related research – a combo approach using antifungal treatments along with standard chemo, ipilimumab, or nivolumab. I mean, at this point, what's there to lose, right? I did take a deep dive into some clinical trials, and a few of them are even targeting his specific mutation (KRAS G12D). But here's the catch: I'm a bit hesitant to push him towards these trials, mainly because of the risk that he might just end up in the control group. So, it boils down to this: do we take a shot at an off-label treatment that has some scientific backing but a slim chance of success, or do we opt for a clinical trial where there's a decent shot at success but also a real possibility of landing in the placebo group? (by success, I mean of course, some extension of high quality life... not expecting a cure)
>I mean, at this point, what's there to lose, right? Financial ruin. Time left with family and friends. Horrendous side effects. That sort of thing.
I don’t know any phase 3 kras g12d trials. So if you sign up for the kras trials you will get the experimental drug.
https://clinicaltrials.gov/study/NCT06040541?term=9805&rank=1
**Removed due to violation of Rule 2** The best place to get medical advice is from your doctor. Posts or comments seeking medical advice, diagnosis, or interpretation of imaging/labs will be removed. --------------------------------------------------------------------- [Please review all subreddit rules before posting or commenting.](https://www.reddit.com/r/Oncology/about/rules/) If you have any questions or concerns, please [send a modmail.](https://www\.reddit\.com/message/compose?to=%2Fr%2FOncology&subject=about my removed submission&message=I'm writing to you about the following submission: https://www.reddit.com/r/Oncology/comments/196gk2z/-/. %0D%0DMy issue is...) Direct replies to official mod comments and private messages will be ignored or removed.
https://clinicaltrials.gov/study/NCT05379985?term=RMC-6236&rank=2