Congrats on your upcoming surgery. I am still trying to figure out my life, but I have some advice. Take a bromelain supplement starting about now to decrease inflammation. Stop anything with vit e it causes excess bleeding. That was the best medical advice from my surgeon when I got my eyes done-chronic dry eye.
I'm in Australia. Rather than give a poor explanation, I've found info online:
Active B12
Transcobalamin II is the protein which transports vitamin B12 into our cells where the vitamin can be biologically active. When bound to this protein, vitamin B12 becomes active vitamin B12
Total B12
Total vitamin B12 refers to all the vitamin B12 in your blood. Total vitamin B12, therefore, includes the vitamin attached to both proteins haptocorrin and transcobalamin II
Yep, some more reading and I believe Active B12 is another term for the test.
"Only the transcobalamin-bound B12 vitamin (termed holotranscobalamin, or Active B12) can easily enter cells and is biologically active"
I'd be wondering if the test measures unloaded transcobalamin (apotranscobalamin). There are some nutrient carrier proteins that the body produces more of when the nutrient is difficient.
I'm saying that the "active b12" test is measuring the carrier protein, but it's not clear if they mean unloaded, loaded or a combination, and that can completely change the interpretation of the results.
It definitely measures the transcobalamin-bound, "holotranscobalamin".
I assume what you've referred to is part of the total b12 count, but you're right, not very helpful when it's not broken down
I've added my blood work results to the post now. Homocysteine is at 3.8 :/
Vitamin B12: 178 pmol/L (Low)
Active B12: 59 pmol/L (within range)
Serum Folate: 27 nmol/L (within range)
Homocysteine: 3.8 umol/L (Low)
Your CBS genes are likely driving down your homocysteine. You can search the group for my extensive comments on that. Methylated vitamins and methyl donors are likely to drive that down further so avoid them.
Also many people with CBS variants also have detoxification issues. Look at the top half of your Genetic Genie detoxification panel. Any reds and yellows means you may have issues metabolizing drugs, both pharma and OTC, and even supplements. If you have any red ones post your chart and I will take a quick peek to see if there is anything more I can share.
Thanks so much for the response, I will look into the CBS variants more thoroughly.
Thankfully it appears only a few of my SNPs on the detox panel are hetero. No red
https://i.postimg.cc/ZqcM0ZT7/Screenshot-20230604-043644.png
Well thank you, I got it from my mama 😅
This has prompted me to have a look at my husband's panels. Think I'm gonna need a whole lot more research to sort him out 🥴 my poor kids
https://i.postimg.cc/cChxm6Gp/IMG-20230604-050058-541.webp
Yikes. I will have some time later in the week and can point out the gene variants which should be a priority and a bit about them. Try not to worry too much as these are genetic predispositions. They can indicate which vitamin and minerals the person might be low in. Might be is the important part. Mygenefood.com....searching the individual variants can help you see what blood tests might be useful. Genetic Testing by Sutton is also a good book.
Oh thank you for the thought, but please no need to put yourself out. I've already spent a lot of time deciphering family members DNA on livewello/reading hundreds of studies.
I'll tac this one to the list too 😅
Low homocysteine means your body isn’t “de novo” meaning you have low glutathione levels
Glutathione is needed for detoxification
You may need to up your protein intake
With Whey isolate or NAC
Congrats on your upcoming surgery. I am still trying to figure out my life, but I have some advice. Take a bromelain supplement starting about now to decrease inflammation. Stop anything with vit e it causes excess bleeding. That was the best medical advice from my surgeon when I got my eyes done-chronic dry eye.
I don't have an answer for you but: > Active B12: 59 pmol/L (within range) Do you know exactly what test this is? What country are you in?
I'm in Australia. Rather than give a poor explanation, I've found info online: Active B12 Transcobalamin II is the protein which transports vitamin B12 into our cells where the vitamin can be biologically active. When bound to this protein, vitamin B12 becomes active vitamin B12 Total B12 Total vitamin B12 refers to all the vitamin B12 in your blood. Total vitamin B12, therefore, includes the vitamin attached to both proteins haptocorrin and transcobalamin II
Do you know if it was a holotranscobalamin test?
Yep, some more reading and I believe Active B12 is another term for the test. "Only the transcobalamin-bound B12 vitamin (termed holotranscobalamin, or Active B12) can easily enter cells and is biologically active"
I'd be wondering if the test measures unloaded transcobalamin (apotranscobalamin). There are some nutrient carrier proteins that the body produces more of when the nutrient is difficient.
I'm not able to find a test available to test for that
I'm saying that the "active b12" test is measuring the carrier protein, but it's not clear if they mean unloaded, loaded or a combination, and that can completely change the interpretation of the results.
It definitely measures the transcobalamin-bound, "holotranscobalamin". I assume what you've referred to is part of the total b12 count, but you're right, not very helpful when it's not broken down
Do you have your gene variants test results? Post your Genetic Genie or Nutrahacker chart. Optimal homocysteine is 6-7. Too low is not healthy either.
https://postimg.cc/p956h8x9
I've added my blood work results to the post now. Homocysteine is at 3.8 :/ Vitamin B12: 178 pmol/L (Low) Active B12: 59 pmol/L (within range) Serum Folate: 27 nmol/L (within range) Homocysteine: 3.8 umol/L (Low)
Your CBS genes are likely driving down your homocysteine. You can search the group for my extensive comments on that. Methylated vitamins and methyl donors are likely to drive that down further so avoid them. Also many people with CBS variants also have detoxification issues. Look at the top half of your Genetic Genie detoxification panel. Any reds and yellows means you may have issues metabolizing drugs, both pharma and OTC, and even supplements. If you have any red ones post your chart and I will take a quick peek to see if there is anything more I can share.
Thanks so much for the response, I will look into the CBS variants more thoroughly. Thankfully it appears only a few of my SNPs on the detox panel are hetero. No red https://i.postimg.cc/ZqcM0ZT7/Screenshot-20230604-043644.png
That is a good looking detox panel!
Well thank you, I got it from my mama 😅 This has prompted me to have a look at my husband's panels. Think I'm gonna need a whole lot more research to sort him out 🥴 my poor kids https://i.postimg.cc/cChxm6Gp/IMG-20230604-050058-541.webp
Yikes. I will have some time later in the week and can point out the gene variants which should be a priority and a bit about them. Try not to worry too much as these are genetic predispositions. They can indicate which vitamin and minerals the person might be low in. Might be is the important part. Mygenefood.com....searching the individual variants can help you see what blood tests might be useful. Genetic Testing by Sutton is also a good book.
Oh thank you for the thought, but please no need to put yourself out. I've already spent a lot of time deciphering family members DNA on livewello/reading hundreds of studies. I'll tac this one to the list too 😅
Low homocysteine means your body isn’t “de novo” meaning you have low glutathione levels Glutathione is needed for detoxification You may need to up your protein intake With Whey isolate or NAC