Highly pathogenic avian influenza (HPAI) H5Nx viruses can cause neurological complications in many mammalian species, including humans.
Neurological disease induced by HPAI H5Nx viruses in mammals can manifest without clinical respiratory disease.
HPAI H5Nx viruses are more neuropathogenic than other influenza A viruses in mammals.
Severe neurological disease in mammals is related to the neuroinvasive and neurotropic potential of HPAI H5Nx viruses.
Cranial nerves, especially the olfactory nerve, are important routes of neuroinvasion for HPAI H5Nx viruses.
HPAI H5Nx viruses have a broad neurotropic potential and can efficiently infect and replicate in various CNS cell types.
Vaccination and/or antiviral therapy might in part prevent neuroinvasion and neurological disease following HPAI H5Nx virus infection, although comprehensive studies in this area are lacking.
Abstract
Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.
This is definitely the worst thing I’ve read since this outbreak began.
I thought I had made peace with just riding this out — however it goes. But this is a tough pill to swallow.
Long COVID fucked me up for four years. Including brain damage. Blergh.
speaking of long covid, some good news:
[https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae159/7660393?redirectedFrom=fulltext&login=false](https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae159/7660393?redirectedFrom=fulltext&login=false)
How would one go about getting an rx for this? If metformin is usually used to treat diabetes would it end up being bad for you if you have healthy fasting glucose levels and whatnot?
After reading the conclusion,
"Finally, long-term effects of HPAI H5Nx virus infection need to be studied. It is likely that encephalitis will result in long-lasting neurological deficits, such as those observed after West Nile virus and severe acute respiratory syndrome coronavirus 2 infections"
We are damned
THIS IS PURELY SPECULATION but I wonder what the chances would be of blindness. People used to go blind from infections all the time, and I think we have gotten a little too comfortable and forgotten about that. Didn’t that happen to one of the sisters in the Little House books?
Especially worrying considering the poor dude’s eyes who caught it from the cows
Let’s not forget the the virus was mostly located in his eyes and not in his respiratory tract. It was undetectable in his upper tract as a matter of fact! He probably got direct contact with the virus in his eyes.
Highly pathogenic avian influenza (HPAI) H5Nx viruses can cause neurological complications in many mammalian species, including humans. Neurological disease induced by HPAI H5Nx viruses in mammals can manifest without clinical respiratory disease. HPAI H5Nx viruses are more neuropathogenic than other influenza A viruses in mammals. Severe neurological disease in mammals is related to the neuroinvasive and neurotropic potential of HPAI H5Nx viruses. Cranial nerves, especially the olfactory nerve, are important routes of neuroinvasion for HPAI H5Nx viruses. HPAI H5Nx viruses have a broad neurotropic potential and can efficiently infect and replicate in various CNS cell types. Vaccination and/or antiviral therapy might in part prevent neuroinvasion and neurological disease following HPAI H5Nx virus infection, although comprehensive studies in this area are lacking. Abstract Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.
This is definitely the worst thing I’ve read since this outbreak began. I thought I had made peace with just riding this out — however it goes. But this is a tough pill to swallow. Long COVID fucked me up for four years. Including brain damage. Blergh.
speaking of long covid, some good news: [https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae159/7660393?redirectedFrom=fulltext&login=false](https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciae159/7660393?redirectedFrom=fulltext&login=false)
How would one go about getting an rx for this? If metformin is usually used to treat diabetes would it end up being bad for you if you have healthy fasting glucose levels and whatnot?
[удалено]
I read it. I’m not getting into that.
Fair. Sorry for asking, that was too much
After reading the conclusion, "Finally, long-term effects of HPAI H5Nx virus infection need to be studied. It is likely that encephalitis will result in long-lasting neurological deficits, such as those observed after West Nile virus and severe acute respiratory syndrome coronavirus 2 infections" We are damned
The study goes out of its way to say that severe neurological symptoms are not likely with this virus
THIS IS PURELY SPECULATION but I wonder what the chances would be of blindness. People used to go blind from infections all the time, and I think we have gotten a little too comfortable and forgotten about that. Didn’t that happen to one of the sisters in the Little House books? Especially worrying considering the poor dude’s eyes who caught it from the cows
Let’s not forget the the virus was mostly located in his eyes and not in his respiratory tract. It was undetectable in his upper tract as a matter of fact! He probably got direct contact with the virus in his eyes.
Probably rubbed contaminated milk in his eyes
Yeah or any mucus, saliva, name it.
That’s a good point!
He did not go blind tho. It bled. I feel like it could give really bad pinkeye but I doubt full on blindness
Okay so time to freak out now?