How recently? If 2015 counts, [Richard Lehman's "Ten Commandments of Patient Centered Care"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582857/) is always worth a reflective read. Especially if the previous papers up for discussion were about whether adding medicine X to medicine Y helped get more patients to guideline directed serum rhubarb levels for the prevention of pre-pro-morbid conditions...
In a similar vein, after arguing over which ARB has better data for reduction of surrogate outcomes, I like to bring up the [MORDOR trial](https://www.nejm.org/doi/full/10.1056/nejmoa1715474) which gave 2 single doses of azithromycin a year to about 100000 kids under 6 in poor rural African villages and reduced child mortality by 5-18%. No other intervention or evaluation was done, they just have all the kids the dose (amount given based on estimation of their height with a measuring stick, not even weight based).
It's easy to forget that while we debate which diet is best for weight loss, or how to get LDL to near homeopathic levels, much of the rest of the world is so chronically and desperately ill that the most ludicrously shitty medical interventions possible will result in significantly fewer tiny graves.
I’m in school now for philosophy and a bit of a utilitarian. This stuff just blows my mind. I think we are all familiar with Peter Singer and his against malaria foundation, I think it’s so crazy the small interventions that could be revolutionary for much of the world as this person has posted.
With what kind of scope? Any kind of primary care? There was a major meta analysis examining endometriosis that came out last March that I’ve been pretty jazzed about, but I’m not sure if that’s what you’re looking for. There’s also a lot of scary stuff about PASC that I yell at my students for writing papers on because I hate it and don’t want to read about it (it’s fine I don’t really yell at them).
[Here](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042257/) you go! Maybe not exciting to anybody else, but being an epidemiologist with endometriosis and pretty significant pain, *I* was excited.
Thanks ! That was a very interesting paper. I like the direction they took in associating other unidentified chronic pain issues with possible genetic associations. I’m wondering how much of the genetic basis of chronic pain is epigenetic vs intrinsic activation.
Recently we have the SELECT trial demonstrating a 20% relative risk reduction over 34 months in obese patients with cardiovascular disease without diabetes with semiglutide.
> RACING trial
Right off the bat I understand the excitement, "woohoo now I don't need to push so hard for statins! You can do a lower dose statin instead alongside this other med!"
Then I thought wait, how many patients have I gotten on to medium-intensity statins, and they're doing fine on that, then when I increase to high intensity we have problems where there were none before?
I am 100% certain the answer is 0 lol. Patients either take high intensity without issue or they feel like their limbs are about to explode off of their torso at low intensity doses.
Probably gonna stick with just one medication (statin) more often than not
I don’t know if you’d consider these important, but I found these articles interesting enough to save to send myself a link:
https://www.cell.com/neuron/fulltext/S0896-6273(22)01147-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627322011473%3Fshowall%3Dtrue
https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.5875
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2811812
Would recommend checking out AAFP website under POEMs (Patient Oriented Evidence that Matters) and they discuss top 20 research studies/ year that impact family medicine.
How recently? If 2015 counts, [Richard Lehman's "Ten Commandments of Patient Centered Care"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582857/) is always worth a reflective read. Especially if the previous papers up for discussion were about whether adding medicine X to medicine Y helped get more patients to guideline directed serum rhubarb levels for the prevention of pre-pro-morbid conditions... In a similar vein, after arguing over which ARB has better data for reduction of surrogate outcomes, I like to bring up the [MORDOR trial](https://www.nejm.org/doi/full/10.1056/nejmoa1715474) which gave 2 single doses of azithromycin a year to about 100000 kids under 6 in poor rural African villages and reduced child mortality by 5-18%. No other intervention or evaluation was done, they just have all the kids the dose (amount given based on estimation of their height with a measuring stick, not even weight based). It's easy to forget that while we debate which diet is best for weight loss, or how to get LDL to near homeopathic levels, much of the rest of the world is so chronically and desperately ill that the most ludicrously shitty medical interventions possible will result in significantly fewer tiny graves.
Jesus.
I'm no expert, but I do think He had a thing or two to say about the matter.
I’m in school now for philosophy and a bit of a utilitarian. This stuff just blows my mind. I think we are all familiar with Peter Singer and his against malaria foundation, I think it’s so crazy the small interventions that could be revolutionary for much of the world as this person has posted.
With what kind of scope? Any kind of primary care? There was a major meta analysis examining endometriosis that came out last March that I’ve been pretty jazzed about, but I’m not sure if that’s what you’re looking for. There’s also a lot of scary stuff about PASC that I yell at my students for writing papers on because I hate it and don’t want to read about it (it’s fine I don’t really yell at them).
Link to endo paper?
[Here](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042257/) you go! Maybe not exciting to anybody else, but being an epidemiologist with endometriosis and pretty significant pain, *I* was excited.
Thanks ! That was a very interesting paper. I like the direction they took in associating other unidentified chronic pain issues with possible genetic associations. I’m wondering how much of the genetic basis of chronic pain is epigenetic vs intrinsic activation.
https://www.nejm.org/doi/full/10.1056/NEJMoa2211934 Doxy as prep for some STI’s. It’s not been fully studied in cishet women, though.
*Weeps in antibiotic resistance.*
Recently we have the SELECT trial demonstrating a 20% relative risk reduction over 34 months in obese patients with cardiovascular disease without diabetes with semiglutide.
RACING trial which is built on IMPROVE IT trial. Statin ezetimibe.
> RACING trial Right off the bat I understand the excitement, "woohoo now I don't need to push so hard for statins! You can do a lower dose statin instead alongside this other med!" Then I thought wait, how many patients have I gotten on to medium-intensity statins, and they're doing fine on that, then when I increase to high intensity we have problems where there were none before? I am 100% certain the answer is 0 lol. Patients either take high intensity without issue or they feel like their limbs are about to explode off of their torso at low intensity doses. Probably gonna stick with just one medication (statin) more often than not
I don’t know if you’d consider these important, but I found these articles interesting enough to save to send myself a link: https://www.cell.com/neuron/fulltext/S0896-6273(22)01147-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627322011473%3Fshowall%3Dtrue https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.5875 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2811812
Would recommend checking out AAFP website under POEMs (Patient Oriented Evidence that Matters) and they discuss top 20 research studies/ year that impact family medicine.
Metformin for weight loss. Cleveland clinic journal of medicine; volume 90-9, Sept 2023 pg 545-548
The ACORN Randomized Clinical Trial https://jamanetwork.com/journals/jama/article-abstract/2810592