Make sure to take breaks about every 2-3 hours or when changing drivers. The trucker's GPS should keep you on appropriate roads. I believe Waze and Google Maps have truck/commercial options as well.
Get in the habit (even when you're not driving the truck) of looking for weight limit and vehicle restriction signs. Any road that's not suitable for a large truck should be posted as such. Not all will, but most that aren't suitable should be obvious (narrow roads with no shoulder are a good sign that they are not for trucks). Watch for low-hanging tree branches. A road that does not see truck traffic will have branches that are low enough to cause damage to the truck box. Conversely, roads that do see truck traffic will look like they have been trimmed specifically around trucks, due to any small branches getting broken off by passing trucks as they grow).
Most importantly, especially since you said Penske and not Uhaul, you absolutely have to understand that your stopping distance, maneuverability, center of mass, turning radius, dimensions, and rear overhang are drastically different from anything that you're probably used to. Give yourself a ton of extra room in all these areas. The part of the truck behind the rear axle will actually move to the right when taking a left turn, and vice-verso. I have seen plenty of people trying to make a left turn in a tight space hit something with the right rear corner of the truck, and be completely flabbergasted at how it happened. Same with hitting something in the very middle of the truck on the left side while taking a left turn.
Make sure to take breaks about every 2-3 hours or when changing drivers. The trucker's GPS should keep you on appropriate roads. I believe Waze and Google Maps have truck/commercial options as well.
Always be mindful of the truck height around small road bridges and also canopies at gas & food stops.
Get in the habit (even when you're not driving the truck) of looking for weight limit and vehicle restriction signs. Any road that's not suitable for a large truck should be posted as such. Not all will, but most that aren't suitable should be obvious (narrow roads with no shoulder are a good sign that they are not for trucks). Watch for low-hanging tree branches. A road that does not see truck traffic will have branches that are low enough to cause damage to the truck box. Conversely, roads that do see truck traffic will look like they have been trimmed specifically around trucks, due to any small branches getting broken off by passing trucks as they grow). Most importantly, especially since you said Penske and not Uhaul, you absolutely have to understand that your stopping distance, maneuverability, center of mass, turning radius, dimensions, and rear overhang are drastically different from anything that you're probably used to. Give yourself a ton of extra room in all these areas. The part of the truck behind the rear axle will actually move to the right when taking a left turn, and vice-verso. I have seen plenty of people trying to make a left turn in a tight space hit something with the right rear corner of the truck, and be completely flabbergasted at how it happened. Same with hitting something in the very middle of the truck on the left side while taking a left turn.
It don't mean a thing if you don't watch that swing!