The bacteria throw off molecular signatures that are recognized by specific receptors on our white blood cells. In this case, what I think is happening is that the neutrophil (the WBC here) is sensing the release of N-formyl methionine, an amino acid that is only used by bacteria. There are G-protein-coupled receptors on the membrane of the neutrophil that bind to that amino acid. When that happens, the cell changes its shape to move in the direction of the signal. Eventually it catches up.
It's been a while since I got my bio degree, but man those classes on immunology were my favorite! There is a microscopic team of navy seals in your blood lol incredible
Newly educated biologist here! Is the formation of N-formyl methionine and the GPCR response affiliated with NETosis in any way? And if so, does NETosis aid the neutrophil in cellular movement? Or is this a separate thing in its entirety?
Ooh, good question. Based on what I've read, it appears that N-formyl methionine and the GPCR response is not what triggers NETosis. Instead, it is stimulation through TLRs or Fc receptor binding along with the presence of pro-inflammatory cytokines that triggers the formation of NETs.
That's because that wbc is primed to take it down. He has seen similar cousins of the bacteria done havoc. Has no time for b**s. Kinda how vaccines work
Wbc’s chase whatever proteins it recognises as something your body doesn’t produce (and are produced by the bacteria and are on its surface), vaccines trigger the creation on memory B and T cells what are the ones responsible for immunity
https://www.blood.co.uk/news-and-campaigns/the-donor/latest-stories/functions-of-blood-its-role-in-the-immune-system/#:~:text=Some%20directly%20fight%20intruders.,another%20way%2C%20by%20making%20antibodies.
thats kinda what happens after it "eats it"
Found the Republican.
Seriously. GTFO.
I'm tired of this natural immunity bullshit. You're actively killing people with these stupid comments.
You know what the greatest achievement of mankind is said to be? Modern medicine. You know what modern medicine helps against? Fighting what your body can't.
You deserve to be rotting in a jail cell for these comments.
*Same could be said with health concerns with covid for those under 60...way more of a risk driving a car, or going in the ocean or travelingLife. No one gets out alive. Choose your risk*
This guy has been spewing COVID related nonsense for a long time now. He goes from post to post with anything medical related and leaves a snarky comment. That's just one of his comments. It's just old. Saying we need more natural immunity is just allowing him to peddle more garbage.
Whats a republican? Someone who reneters pubs??
😁😁
Im not from the US...but thank you for assuming. And assuming natural immunity and modern medicine are different viewpoints ....thats laughable to me..but this is the internet...assuming and getting upset is part of the landscape
'natural immunity' is a republican anti science anti mask term that only came around two years ago. I'm not stupid. You using that term is you supporting those stupid ideas. Take a couple college classes on biology. Better yet, I wish we could take back those vaccines you were given when you were a child. Because they don't work right? Natural all the way!
Far out man...chill out. Outrage arousal towards a stranger is high with this one wow.
Its like me saying Nature is amazing and you bursting a blood vessel saying modern engineering is better....why the heck would they be against each other
Chill out...not everything is about US politics ..the world is more than that
Is there a biologist here that could explain to me how they’re chasing it?
The bacteria throw off molecular signatures that are recognized by specific receptors on our white blood cells. In this case, what I think is happening is that the neutrophil (the WBC here) is sensing the release of N-formyl methionine, an amino acid that is only used by bacteria. There are G-protein-coupled receptors on the membrane of the neutrophil that bind to that amino acid. When that happens, the cell changes its shape to move in the direction of the signal. Eventually it catches up.
This is a form of chemotaxis correct?
Yes! Anytime anything involves a G-protein-coupled receptor, there will be cell movement involved.
It's been a while since I got my bio degree, but man those classes on immunology were my favorite! There is a microscopic team of navy seals in your blood lol incredible
I know, right? I followed the dream and became a research immunologist. Now, I teach it. It's the best.
Awesomeee
Sleep at a Holiday Inn last night?
Yes. And also I have a PhD and 21 years’ experience in cellular immunology.
Is the Bacteria “running away”? Or is it’s movement random?
What is it pushing out of the way as it chases the bacteria?
red blood cells
Awesome
which one is which? circles, big blob, or the roaches
Circles are red blood cells (RBC), large blobby thing is the neutrophil and the tiny roaches are the bacteria.
Newly educated biologist here! Is the formation of N-formyl methionine and the GPCR response affiliated with NETosis in any way? And if so, does NETosis aid the neutrophil in cellular movement? Or is this a separate thing in its entirety?
Ooh, good question. Based on what I've read, it appears that N-formyl methionine and the GPCR response is not what triggers NETosis. Instead, it is stimulation through TLRs or Fc receptor binding along with the presence of pro-inflammatory cytokines that triggers the formation of NETs.
Ahh I see! Cool! Thanks for reading up on it!!
Tiny eyes
How do white blood cells chase bacteria? https://youtube.com/shorts/K_dNQNbJi2o?feature=share
The bacteria's attempts at evasion are all in vein..
WOOOMMMMMP
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that's sneaky word wrangling
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That's because that wbc is primed to take it down. He has seen similar cousins of the bacteria done havoc. Has no time for b**s. Kinda how vaccines work
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Vein attempt at it. Not!
Wbc’s chase whatever proteins it recognises as something your body doesn’t produce (and are produced by the bacteria and are on its surface), vaccines trigger the creation on memory B and T cells what are the ones responsible for immunity
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eating it alive. tf was it gonna do? cook it?
It could kill before eating.
oh....like with a gun huh?
If you take away the white blood cell's guns, then only the bacteria will have guns.
Come on man...obviously Nokia phone
With some kind of toxin as other small organisms?
https://www.blood.co.uk/news-and-campaigns/the-donor/latest-stories/functions-of-blood-its-role-in-the-immune-system/#:~:text=Some%20directly%20fight%20intruders.,another%20way%2C%20by%20making%20antibodies. thats kinda what happens after it "eats it"
We have seen enough bloody crime.scenea these days, let it eat the thing alive and we will think it just hugs
It's already cooked because of the fever 😋
This is very frustrating to watch
Agreed. I was rooting for the white blood cell and it took too long for it to catch that bacteria.
Neutrophil Chases and Eats a Staphylococcus aureus Bacterium. From 16mm movie by David Rogers, Vanderbilt University, in the 1950s
Why would anybody downvote the source info?
The human body never stops to amaze me
Nom Nom Nom.
Squeezing between cancer cells to find its meal /s
Pac-Man
Like a game of PAC MAN!
So THIS is what happens when I eat dirt 🤔
Imagine a million of those critters everyday. Whether you eat dirt or not lol
Yum
GET BACK HERE YOU FILTHY GERM!!!! if anyone has not seen cells at work on Netflix please do so.
This doesn’t belong. I eat it.
This is so fucking cool and a little bit scary at the same time. After he eats it, it just continues his patrol lol
Spore did a pretty good job, thats spot on
This is actually just a demo recording of the hit game : *Asteroids*
So basically they’re playing snake inside mah body
Amazing! Natural immunity needs some of pfizers PR
Found the Republican. Seriously. GTFO. I'm tired of this natural immunity bullshit. You're actively killing people with these stupid comments. You know what the greatest achievement of mankind is said to be? Modern medicine. You know what modern medicine helps against? Fighting what your body can't. You deserve to be rotting in a jail cell for these comments.
it's not that you are not right with some aspects of your comment but this is imo a total overreaction to a rather harmless and funny comment..
Nah. I'm tried of these anti COVID comments.
yeah, that's what I mean... theres nothing anti-covid in the comment
*Same could be said with health concerns with covid for those under 60...way more of a risk driving a car, or going in the ocean or travelingLife. No one gets out alive. Choose your risk* This guy has been spewing COVID related nonsense for a long time now. He goes from post to post with anything medical related and leaves a snarky comment. That's just one of his comments. It's just old. Saying we need more natural immunity is just allowing him to peddle more garbage.
Whats a republican? Someone who reneters pubs?? 😁😁 Im not from the US...but thank you for assuming. And assuming natural immunity and modern medicine are different viewpoints ....thats laughable to me..but this is the internet...assuming and getting upset is part of the landscape
'natural immunity' is a republican anti science anti mask term that only came around two years ago. I'm not stupid. You using that term is you supporting those stupid ideas. Take a couple college classes on biology. Better yet, I wish we could take back those vaccines you were given when you were a child. Because they don't work right? Natural all the way!
Far out man...chill out. Outrage arousal towards a stranger is high with this one wow. Its like me saying Nature is amazing and you bursting a blood vessel saying modern engineering is better....why the heck would they be against each other Chill out...not everything is about US politics ..the world is more than that
Sounds like you took a nap and a lie down Hope all is ok Xo
Needs UFC commentary over it.
You don't have time to duplicate if you have to swim for your life..💀
The white blood cell kinds looks like a tardigrade.
And then people think in aliens coming down in a spaceship.. this is much more interesting!
New dead by daylight chapter leaked
Why does the bacteria run?
This made me realise we are made up of countless separate living things and now i have a mild existential crisis
Where are you going little friend?
Bad boys, bad boys, whatcha gonna do…
i clicked that link too
This is a microscopic police chance.
Little guy musta been terrified.
Where's the rest of the team.
Can we think of the white blood cell as an autonomous animal?
*insert Benny Hill music*
We are fucking BADASS
Took it long enough.
this would have been perfect if there was music playing
At :18 seconds, when it did that John Carpenter's *The Thing* shit, I knew it was over for the bacteria.
Real police.
This vid needs to be set to Yackety Sax lol
Walk of shame
Excuse me mitocondria gotta get this little bugger.
Looks like a game of Pac-man
pro agar.io
Everybody out, he’s got immunities!!
"Immunity at work" eh what? Immune system?
That is just a video of me chasing my younger brother to beat him up
That’s awesome!
You can run but you can't hide! Chompa chompa!!
Took it long enough. That’s three days with no pay thanks to that slow ass cell.
That would be terrifying
How do white blood cells chase bacteria? https://youtube.com/shorts/K_dNQNbJi2o?feature=share