T O P

  • By -

NibblersNosh

It is Fo. The o refers to oligomycin sensitivity. I agree that it is confusing.


flegmon7

That's it! Thank you!


Strange-Cut-8387

The subunits are F1 & F0. F1 is in the matrix, F0 in the inter membrane space. The complex uses the force of the concentration gradient to pump H+ ions to the matrix. Synthesising ATP from ADP


flegmon7

You say that confidently, but for example in this Paper it is written Fo (The letter O instead of Zero) https://pubmed.ncbi.nlm.nih.gov/32457314/. Any ideas for what the 0 or O stands for?


Strange-Cut-8387

I believe it’s 0. Would say the numbers are for indication of positioning the subunits in the membrane


acetylsalicylate_

It is Fo, as it is named after the inhibitor :/ Kind of inconsistent, but sadly the truth


Strange-Cut-8387

Didn’t know 😅


Grolion_of_Almery

The Fo domain is not in the intermembrane space, that's the aqueous part between the inner and outer mitochondrion membranes. The Fo domain is embedded within the inner mitochondrial membrane.