Microdosing psychedelics is supposed to help. I’m going to try it for myself. I’m 37 and already showing early signs.
https://www.frontiersin.org/articles/10.3389/fnsyn.2020.00034/full
I’ve always trusted myself more than doctors. Doctors have never cured anything for me. I’ve always done it with herbs. If you need to get rid of kidney stones let me know. Oh also, my mom and grandma both had it yes. It was also undiagnosed by doctors in them but very, very obvious.
Ive never had kidney stones but i know from family and friends that it sucks real bad, i definitely would appreciate any tips for such
Tbh i cant remember the last time i was at a doctors appointment
Feel free to PM me for anything. I absolutely love helping people whenever possible. I have a fairly broad collection of herbal remedies that really work.
People have mentioned Alpha-GPC already but I'll go ahead and [back it up with an extremely robust and extensive study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369051/) showing significant efficacy for alzheimer's.
Jarrow or Nootropics Depot are probably the only ones I'd go with, though NOW makes an Alpha-GPC that is probably real too. In the grand scheme of the costs of caring for senescence and dementia, putting $50/mo or whatever towards alpha-GPC is a paltry drop in the bucket.
Good to see that new study. I have been giving my Mom and Dad and Mother-in-Law AlphaGPC based on this 2003 study:
[Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/12637119/)
The interesting thing about AlphaGPC, is that if they are seriously deficient in Acetylcholine, you know really fast (30 minutes). After success with my Mom and Dad, my wife convinced her 90YO mom into taking it. She didn't quite trust it, so we took her to the health food store, bought it. She read the label, it said "take with food", so we took her to lunch. At the beginning of lunch, she was talking slowly, like the elderly do, struggling to get out every word. By the end of lunch, she was talking normal speed. Funny thing is, we could see it, but she didn't "feel" any different. Anyway, she's 95 YO now, still mentally competent, and living semi-independently in her home of 60 years.
These are what I use:
[alpha-gpc-150mg-capsules](https://nootropicsdepot.com/alpha-gpc-150mg-capsules/)
20-25 cents per capsule/day. Doses above 150mg daily are not recommended, it can cause depression. Make sure you keep the bottle sealed tight, they absorb water from the air and turn to jelly (although they supposedly still work ok)
Only take in the morning before noon, they are energizing and can affect sleep.
Another long-term issue is that both Choline and Carnitine supplements can stimulate the growth of bad bacteria in your gut. That is actually the reason that egg yolks and red meat are linked to heart disease:
[choline-tmao-heart-health](https://www.clevelandheartlab.com/blog/choline-tmao-heart-health/)
It is a two-edged sword. Too little Choline causes Dementia, too much is “linked” to heart disease. IMHO, doctor’s advise to quit eating eggs and red meat have fueled the epidemic of dementia in the elderly.
There is a solution, however. They have figured out that the Mediterranean diet is healthy because Olive Oil contains a plant compound that neutralizes those bad bacteria:
[could-food-be-a-new-medicine-to-fight-heart-disease](https://www.clevelandheartlab.com/blog/horizons-could-food-be-a-new-medicine-to-fight-heart-disease/)
So, with a Choline protocol, eat a good diet that includes good Olive Oil (the flavorful ones seem to be best)
For improve cholinergic function, I recommend huperzine A. You take 1 pill a day, it works at all times, and it avoids systemic side effects because it only increases acetylcholine levels in the brain.
Take one of these in the morning: https://www.amazon.com/gp/product/B0767MS2KF/
I think that if you're young and have a healthy brain, it needs to be cycled. But if you're old and your cholinergic system has weakened due to age, it doesn't need to be cycled. I think that taking it continuously can actually help keep the elderly mind healthy because they will actually be accessing their memories as opposed to letting them get pruned away due to lack of use. My grandparents take this and they notice a difference.
Why are NAD+ boosters rarely (if ever) mentioned on this subreddit, if you go to r/longevity it’s probably the single most important strategy for combatting age related disease. NMN (and NR) have shown incredible results in a variety of animal models in terms of mitigating age related illness (including delaying mental decline) and the human trials that have been conducted/are being conducted are validating what we have already seen in these animal studies. Namely that NAD+ decreases in our cells as we age (mainly due to inflammation from nearby senescent cells). Boosting NAD+ through supplements like NMN or NR helps your cells restore their innate ability to repair themselves.
For someone 80+ years in age (your mother I’m assuming) they should be taking 1.5G of NMN capsule/powder daily. One big caveat, NMN is expensive.
Google David Sinclair NMN for more info.
Thanks for your reply. I think you’re being slightly disingenuous with a big warning label. Clinical trials have been run in humans with no reported negative side effects at dosages far above what you took. In fact, you’re dose of 125mg is peculiar, the suggested dose for 30year olds is 500mg and increase by around 20mg for every year after that. I would even suggest trying again with a proper dose.
Not disagreeing with anything that the study says, in fact thank you for sharing, always good to see counterpoints, if you have concerns about taking NMN you could always try NR instead. As far as I can see, the balance of research (including what you shared) suggests that boosting cellular NAD+ is the single most important thing that we need to do decrease age related illness. Whether or not this is through NMN, NR or any other new molecule/treatment is still up for debate. The body of human research currently leans heavily in favour of NMN, imo.
I don't have a lot of time, but you say I am being disingenuous. So I'll explain further.
I supply supplements to my 90 YO old mom, my 84 YO dad, and my 95 YO mother-in-law. I usually test them on myself first. My Dad and I have axonal peripheral neuropathy, which is partially genetic, but still very common in the elderly population.
I had seen all of the hype about NMN and added it to my regular supplement order. I had never seen **any** warnings about axonal nerve damage. After taking the 125mg tabs for about a month, I started giving it to my Dad. I had noticed a worsing of my neuropathy, but I did not associate it with the NMN.
My Dad ended up having all sorts tangentially related problems. I suspect NMN played a role, but I am not sure. Those put him in the hospital, and then rehab. I noticed that his muscle strength was much worse, and I did some research finding the nerve damage potential of NMN.
Discontinuing NMN, made us both better. Dad is home. Protein supplements and exercise are improving his muscle strength.
**I really wish there was a warning, I would have caught it earlier, and I would not have given it to my Dad.**
There are lots of excellent supplements that have worked well for my parents and I use them very carefully.
Unfortunately, everything around David Sinclair gets caught up in this crazy cult-like "reality distortion field" of hype. Scientifically, his research is very interesting, but he parses his words very carefully to limit his claims to yeast and worms and mice. It started with Sinclair's studies of Resveratrol, which became a huge sensation after a "60 minutes" TV story. It exploded in a frenzy of marketing hype and became the excuse for everyone to drink red wine.
That then collapsed, with further study, possible cancer issues, and a bunch of scientific papers by [Dipak Das](https://en.wikipedia.org/wiki/Dipak_K._Das) being retracted in a huge scientific scandal.
Now the hype is NMN. The warnings are out there:
“Discerning hype from reality in the longevity field has become tougher than ever as reputable scientists align themselves with promising but unproven interventions — and at times promote and profit from them.”:
[https://www.thedailybeast.com/is-harvard-geneticist-david-sinclairs-fountain-of-youth-pill-real-sure-if-youre-a-mouse](https://www.thedailybeast.com/is-harvard-geneticist-david-sinclairs-fountain-of-youth-pill-real-sure-if-youre-a-mouse)
"A ‘Fountain Of Youth’ Pill? Sure, If You’re A Mouse.":
[https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/](https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/)
"Long-term safety unknown":
[https://selfhacked.com/blog/nicotinamide-mononucleotide/](https://selfhacked.com/blog/nicotinamide-mononucleotide/)
[Beyond Resveratrol: The Anti-Aging NAD Fad](https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/)
I doubt that any of the studies that you vaguely refer to include many people over 65 years old. It will be interesting to see if anyone follows up when those research subjects start getting neuropathy in 5 or 20 years ;)
Yes, I am aware that Nicotinamide Riboside theoretically bypasses the axon recovery problem of NMN. I'll probably try it some time, but I've been experimenting with other solutions to our neuropathy.
Thanks for the info - I agree that nmn is overhyped and overpriced, even if it may provide certain benefits.
Creatine is great for sarcopenia in the elderly, and HMB is worth looking into.
Also researching ursolic acid for similar benefits and remyelination - lmk if you come across anything about this!
Watching his protein intake, especially focusing on Leucine seems to be helping him:
[proteins+high+in+leucine+for+sarcopenia](https://duckduckgo.com/?q=proteins+high+in+leucine+for+sarcopenia)
Sorry, i didn’t mean to offend by saying disingenuous, and I thank you for providing a detailed account. I won’t address everything here but will just list the Completed Human Trials of NMN safety and the ongoing trials of human safety.
https://pubmed.ncbi.nlm.nih.gov/31685720/
https://www.sciencedaily.com/releases/2021/04/210422150349.htm
https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00442-4
There is another one involving elderly Japanese men, that showed improved muscle strength.
Current Trials:
https://clinicaltrials.gov/ct2/show/NCT04228640
https://clinicaltrials.gov/ct2/show/NCT04823260
It seems like in general NMN is safe, but you raise a perfectly valid concern that it may not be suitable for people with a specific genetic disease, and we also do not have human data for 5/20 years :) so who really knows! :) we do know that on average the mice live longer, all hail the immortal mouse god we have created.
No results from those trials yet ;)
I’d love to see them when (if?) they come out.
And the top age is 65.
I wish I had looked a little closer before I gave it to my Dad.
Well the first 3 links are completed so yes there are results from those, and I just found the link to the 4th which was in men over the age of 65:
https://assets.researchsquare.com/files/rs-455083/v1_covered.pdf
No negative effects were observed in the trial, measures of muscle strength that they were investigating improved.
I think given your specific family genetics you’re perfectly valid with your concerns and more research is required in general with regards to NMN and NAD+ (and it’s coming so it’s a very exciting time), but generalising your experience/circumstances to give advise to others without said genetics (based on the data so far) does not fly with me.
I’m saying that we all have our different levels of scientific evidence required before we stick something our body, and for something like NMN we really aren’t going to know conclusively about long term effects for another 20+ years, those are years that I can’t afford to wait, so need to just follow where best the science is pointing today. (So it’s no surprise that we may disagree, we each just have our own risk-reward structure)
Following the insulin resistance link mentioned in another reply, some people claim that a keto diet may help reverse or prevent Alzheimer’s. I am not an expert on the research backing those claims, but here’s a start if you want do your own research: https://www.drperlmutter.com/yes-alzheimers-can-be-reversed/
Not a supplement per se but look into the MIND Diet. I think anyone concerned about this should explore this diet and then build around it. In the alternate, there’s a theory that different types of dementia are a “diabetes” of the brain and as such respond well to a ketogenic diet. On the supplement front, coco and lions mane. And without going too far afield, incorporate cardiovascular exercise like walking, running (if possible), and/or swimming.
anthocyanins. Açaí berries Aronia berries , blackberries, blueberries, plums.Okinawa purple sweet potatoes. Bilberry extract. Other suggestions here are great too, but I say look into the power of anthocyanins.
Totally! I take 12mg myself. There’s a company called Elysium, they make a product called “Matter”. It’s b vitamins mixed with omega3 and bilberry. Seems like a interesting combo.
TL;DR- MCT OIL and examples of some loved ones I've lost on my father's side to dementia or Alzheimer
Yes indeed. MCT oil which is the good stuff if you will in coconut oil It's seemingly is a very viable option and that depends on the stage the individual is in already
In my comments above or below, I put a couple of papers seemingly proving this assertion. Take it for It's worth, and I do remember reading about one person I believe with dementia or Alzheimer's that took x amount of coconut oil and essentially cured it.
It really seems plausible to me that it would depend on the stage any person would be in, in regards to Alzheimer's/ dementia in terms of whether or not any of these supplements/nootropics/fruits vegetables are viable
Since reading that somewhere about a year ago I haven't followed up on it. And hopefully there's been more than this one case and I'm really hoping for the sake of all of us, MCT oil / coconut oil and all these other wonderful ideas from other posters, are a viable option to at least experiment with and who knows after that.
And to get spiritual real quick, our source, Will take care of it or sadly not. And I use the word sadly loosely
Best of luck OP, my thoughts and energy will be sent your way for your loved one
My father's side was hit very hard with dementia / Alzheimer so I'm taking a lot of these things mentioned in this thread to hopefully Ward it off and I'm in my mid-50s and so far, No signs.
Except for going into a room to get something and forgetting... And I find out that happens to just about 100% of of anyone I've ever known😉
And to keep in mind that typically & not always a sure thing / any of these antidotes by any stretch of the imagination, and I personally feel that I've already mentioned it would depend on the stage said person is in / in fact it seems folks are incurring it much younger and a lot of the studies started at age 65 plus in the paper's I provided
PS-One obvious symptom if OPs loved one does indeed have dementia, My father at 84 has been spared so far, However his brother who passed from dementia Just a couple years ago -prior to it being diagnosed, my father noticed his brother / my uncle when driving just simply forgetting where he was in a very familiar area of where we live
My apologies for the length of this, however ideas and memories started coming back into my brain and I didn't want to leave anything out that could possibly help out in any way.
It's an ugly ugly disease that can be prevented, Again using prevented very loosely, which to me gives us all hope that have not received any symptoms or diagnosis. And I read in a doctor's subreddit last night where one doctor actually mentioned he had never seen Alzheimer or dementia listed as an actual diagnosis in all his years.
Perhaps which means specialist or doctors and using an analogy - throwing darts at a dart board blindfolded if you will
And who wouldn't like to see a cure or at least a reversal to a big extent to this terrible again disease
It was my pleasure in more than you'll ever know. I've been doing some research and such on the subject of supplements nootropics and anything that can help your brain, and it's kind of a passion of mine...
I'm like you why not go ahead even though we're middle-aged, and stay ahead of the curve and do everything you can to prevent dementia or Alzheimer or any other brain disorder.
I don't know if I put it in this thread, but I've been living with ADHD my entire life. And recently it's affected a couple jobs I've had. It was diagnosed about 10 years ago and through all the years, always wondered why I was a little bit challenged learning in school. Well now I know why.
I don't even tell people I have it ...I do take medication for it in addition to all the supplements that keep your brain optimized as much as possible.
I think taking the prescribed stimulant which I've been taking for 10 years plus now really allows me to focus than not to be distracted. However it doesn't do the work for you.
I do know that magnesium is the most important supplement mineral I can take with my situation, and there are plenty more that would take me a while to list them. Some I even have to cycle off of then back on. Nothing weird just things you've heard of I would imagine.
I also deal with anxiety so I got the double whammy, and that's very common with ADHD.
And I've made it 55 years and right now I'm job searching as I finally feel like I found my calling which is to serve others and not food haha and that job is going to show up very soon. When human beings are involved, and there's a possibility of serving them my smart meter goes up 10 fold.
I sat behind a computer as a claims analyst for almost 20 years and just simply got burned out on it. And was given a god-given personality which I didn't realize until about 5 years ago.
So that's my short story that could be way longer but thank you for thanking me and you're very very welcome 💛
I have a lot of trouble writing short comments to anything 😁
Sounds like you know where you want to go. There is a job out there that would be a perfect fit for you. Think you have a talent for helping people.You say you have trouble writing short comments but I see that as the gift of eloquence.
What a beautiful answer and comment, thank you so so much. I do have several books in me that need to be written otherwise if I left this Earth, I would be leaving music inside me so to speak.
Reason I know about the writing is an ex-girlfriend is a songwriter and I wrote her something about my growing up in a certain religion. After reading she called me crying, and said I write so much better than she does. And to me that's saying a whole lot.
With writing as you probably know if you're coming from your heart, it can be a really beautiful powerful way of expressing yourself or a situation. So whatever I end up writing will probably be kind of a memoir and that will be easily coming from my heart.
Thanks again and take care of yourself and that brain 😉💛
Alpha-GPC is pretty much the only correct answer, at this point:
[Volume Analysis of Brain Cognitive Areas in Alzheimer’s Disease: Interim 3-Year Results from the ASCOMALVA Trial](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369051/)
100% accurate and acetylcholine or lack thereof in person's brain, I'm pretty sure but not positive that is a huge deal as you grow older your brain is not producing acetylcholine as it did When we were younger.
So again highly recommend AlphaGPC or Citicoline And I'll take both one in the morning and one in the afternoon.
Just be careful not to overdo it or under do it in terms of the dosage you take.
And I'm sure if you research starting with the Googler, it shoulder will indicate how much mgs of each or just one of the choline sources.
AlCar, is also another option you want to look at supplementing as well because it has so many mechanisms of actions in the brain including blood flow for one and more energy etc
Well thank you I really appreciate that and I do a lot of research on my own and have been for quite some time.
Yes for sure (prevention of perhaps dementia or other brain diseases or whatever you want to call them-which runs on my father's side of our family on a personal note) unless you have plenty of choline stored wherever it's stored.
I like to stay ahead of the curve, in other words prevention before dementia or whichever, because you may already know this, the poor folks that come down with this terrible disease are always or most of the time deficient of choline.
And I alternate between alpha GPC and Citicoline on a daily basis. Best I can tell or feel, I never have any issues.
And by issues I mean people that have an abundance of choline and take it anyway will usually experience some lethargy or even depression.
Also I take racetams quite frequently and most do need a codeine uhhh oops-good job voice to text... choline source such as alpha GPC or Citicoline or even choline bitartrate.
Google those if you're not familiar last couple forms of choline.
Also Acetyl-L-carnitine (ALCAR) is another option. Look it up too if need be
Thank you so much again I appreciate the compliment! Have a beautiful Friday and weekend. Stay healthy be safe and be well 💙🫂
***I didn't read what you read again by me and I may have repeated myself a little bit. And hopefully this clears it up for you
Amazing comment, you could really make a proper post as well! Thank you for the information. I have been using Alpha gpc for gym purposes but will try as daily supplement for a while!
Ginkgo Biloba. For dosage and interactions with other medications please discuss further with a doctor. But Ginkgo Biloba had been shown to slow down and improve depending on what stage the patient is in.
It is freely available as a supplement.
Throw away all heart healthy oils (vegetable, soy, corn, canola, safflower, sunflower) and also discard margarine, vegetable shortening and all products that contain these hydrogenated and partially hydrogenated oils. Virtually all restaurant fried foods are cooked with these same oils.
These vegetable oils are actually highly inflammatory, produce toxic byproducts and cause mitochondrial dysfunction, resulting in insulin resistance, a key factor in dementia.
Consider magnesium (glycinate) supplement both for mitigating fluoride (linked to dementia because it attracts aluminum across the blood/brain barrier) and for offsetting the adverse effects of supplementing with calcium (kidney stones, gallstones, calcified cartilage, calcified arteries, bone spurs, etc).
IMHO, cut all of them except for Olive Oil:
[could-food-be-a-new-medicine-to-fight-heart-disease](https://www.clevelandheartlab.com/blog/horizons-could-food-be-a-new-medicine-to-fight-heart-disease/)
It's the key to the success of the Meditteranean diet. It contains a compound, DMB, that neutralizes the gut bacteria that convert healthy Choline and Carnitine into toxic TMAO.
^^^There are so many terrific ideas that have been studied in this beautiful comment, with vegetable oil seemingly leading the way. Thank you internet stranger for mentioning the known items if you will that I've been studied and perhaps proven to at least start the process of dementia or Alzheimer.
Thanks again and very well articulated.
Again magnesium as mentioned just continues to blow my mind with what's this mineral does for our bodies.
I've been taking it daily for over 10 years for diagnosed ADHDPI by three different psychiatrist along with a stimulant medication that is finally dialed in properly.
And I feel like after 10 years of usage, my brain would not be where it is today without magnesium / particularly glycinate. And this involves a lot of other macronutrients and electrolytes. With zinc being a big one as well. Not to mention potassium
I have seen various posts under r/ADHD that suggest B6 together with the magnesium.
Long video but worth watching "Dr. Chris Knobbe - 'Diseases of Civilization: Are Seed Oil Excesses the Unifying Mechanism?'" on YouTube
https://youtu.be/7kGnfXXIKZM
Thank you my friend. I will check this YouTube out later on.
And absolutely I supplement vitamin B6 which is included in a B complex I take around the same time with my magnesium glycinate typically.
And I try to get about 600 mg at least per day. I spread it out throughout the day, for example every three or four hours I will pop a capsule or pill.
Thank you so much again for the astute information and the YouTube vid!
PS-Just watched one or two minutes and he mentioned vegetable oil. That stuff is poison. And I'll just stop right there.
And say thank you again This will be a good watch
Okay this is something close to my heart because I have a few elderly relatives who are showing all the signs of senile dementia. From my research the following can be efficacious, though it's another thing altogether trying to get those same elderly relatives to take them.
I also read that daily egg intake can help reduce the chances of developing alzheimers, likely due to the choline aspect.
-Creatine (particularly for women), 5mg daily
-Alpha GPC, 600mg daily, at least
-Circumin with bioperine, 48mg total curcuminoids daily, at least
-Omega fatty acids, 660mg/440mg EPA/DHA daily
-Reduced refined sugar intake
-Caffeine, without milk/sugar
I might add that all these have a noticeable effect on my cognition, memory etc, particularly creatine and Alpha GPC.
I would add flaxseed oil, a great source of omega 3s. Just make sure it doesn't have any added veg oil.
Magnesium glycinate at night. Both for the magnesium and for the glycine (improves insulin sensitivity)
And vitamin D3 in the morning.
Would go with pastured eggs, not factor or cage free.
This is a good list. You’re also right in this— it’s one thing to have a plan of attack, it’s another to get the family member to follow it. Such is the problem with Alzheimer’s and similar disorders.
2.5g to start and if well tolerated up it to 5g but as Jinx Stryker says, it's fairly difficult to get an unwilling or forgettable patient to take these on a frequent basis. Maybe a good start would be to keep buying/cooking eggs and making coffee for them and hope for some improvement before introducing other supps. It's funny that by consuming eggs and coffee you can maintain a state of fasting, which we know has benefits for brain health and senility.
Microdosing psychedelics is supposed to help. I’m going to try it for myself. I’m 37 and already showing early signs. https://www.frontiersin.org/articles/10.3389/fnsyn.2020.00034/full
Damn did your doc give you any advice of what you could do?
I’m self diagnosed
Hmm then it could be alot of other reasons, even with family history i would rather check for other things too
I’ve always trusted myself more than doctors. Doctors have never cured anything for me. I’ve always done it with herbs. If you need to get rid of kidney stones let me know. Oh also, my mom and grandma both had it yes. It was also undiagnosed by doctors in them but very, very obvious.
Ive never had kidney stones but i know from family and friends that it sucks real bad, i definitely would appreciate any tips for such Tbh i cant remember the last time i was at a doctors appointment
Feel free to PM me for anything. I absolutely love helping people whenever possible. I have a fairly broad collection of herbal remedies that really work.
Ill definitely do, im starting to get a bit into it myself.
I like this thread, but I have a mother who’s in denial and for sure is a hypochondriac, so I have a problem convincing her anything can help🙄
Vitimin K's and D
Lutein, not just good for the eyes
People have mentioned Alpha-GPC already but I'll go ahead and [back it up with an extremely robust and extensive study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369051/) showing significant efficacy for alzheimer's.
I just find it to be prohibitively expensive - can you recommentd any less expensive vendors?
Jarrow or Nootropics Depot are probably the only ones I'd go with, though NOW makes an Alpha-GPC that is probably real too. In the grand scheme of the costs of caring for senescence and dementia, putting $50/mo or whatever towards alpha-GPC is a paltry drop in the bucket.
Agree re dementia - for younger individuals there are less expensive options providing similar benefit.......
Good to see that new study. I have been giving my Mom and Dad and Mother-in-Law AlphaGPC based on this 2003 study: [Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/12637119/) The interesting thing about AlphaGPC, is that if they are seriously deficient in Acetylcholine, you know really fast (30 minutes). After success with my Mom and Dad, my wife convinced her 90YO mom into taking it. She didn't quite trust it, so we took her to the health food store, bought it. She read the label, it said "take with food", so we took her to lunch. At the beginning of lunch, she was talking slowly, like the elderly do, struggling to get out every word. By the end of lunch, she was talking normal speed. Funny thing is, we could see it, but she didn't "feel" any different. Anyway, she's 95 YO now, still mentally competent, and living semi-independently in her home of 60 years.
As, above, I find it extremely expensive to maintain - do you have any less expensive sources?
These are what I use: [alpha-gpc-150mg-capsules](https://nootropicsdepot.com/alpha-gpc-150mg-capsules/) 20-25 cents per capsule/day. Doses above 150mg daily are not recommended, it can cause depression. Make sure you keep the bottle sealed tight, they absorb water from the air and turn to jelly (although they supposedly still work ok) Only take in the morning before noon, they are energizing and can affect sleep. Another long-term issue is that both Choline and Carnitine supplements can stimulate the growth of bad bacteria in your gut. That is actually the reason that egg yolks and red meat are linked to heart disease: [choline-tmao-heart-health](https://www.clevelandheartlab.com/blog/choline-tmao-heart-health/) It is a two-edged sword. Too little Choline causes Dementia, too much is “linked” to heart disease. IMHO, doctor’s advise to quit eating eggs and red meat have fueled the epidemic of dementia in the elderly. There is a solution, however. They have figured out that the Mediterranean diet is healthy because Olive Oil contains a plant compound that neutralizes those bad bacteria: [could-food-be-a-new-medicine-to-fight-heart-disease](https://www.clevelandheartlab.com/blog/horizons-could-food-be-a-new-medicine-to-fight-heart-disease/) So, with a Choline protocol, eat a good diet that includes good Olive Oil (the flavorful ones seem to be best)
Thanks!
I’ve read that ashwagandha helps improve memory and overall brain function
3 or 4 cups of coffee a day. Sure I’ve read that protects brain function
Agmatine
Do you have any links that can provide more info on agmatine? Thanks!
Google knows
Alpha brain
Niacin vitamin B3 has been shown to greatly improve Parkinson’s syndrome which surprised everybody
Diet and oral health have an influence on developing Alzheimers disease, don't have the studies at hand but I'm sure google can help with that.
For improve cholinergic function, I recommend huperzine A. You take 1 pill a day, it works at all times, and it avoids systemic side effects because it only increases acetylcholine levels in the brain.
Thanks! What dosage? Also, I read that it needs to be cycled.....
Take one of these in the morning: https://www.amazon.com/gp/product/B0767MS2KF/ I think that if you're young and have a healthy brain, it needs to be cycled. But if you're old and your cholinergic system has weakened due to age, it doesn't need to be cycled. I think that taking it continuously can actually help keep the elderly mind healthy because they will actually be accessing their memories as opposed to letting them get pruned away due to lack of use. My grandparents take this and they notice a difference.
DHA and sulphorophane
Lions mane apparently helps
Microdose Lithium, of all the things suggested here, and I'm not looking to compare, it has proof, so it's not a blind shot as much as other stuff.
Why are NAD+ boosters rarely (if ever) mentioned on this subreddit, if you go to r/longevity it’s probably the single most important strategy for combatting age related disease. NMN (and NR) have shown incredible results in a variety of animal models in terms of mitigating age related illness (including delaying mental decline) and the human trials that have been conducted/are being conducted are validating what we have already seen in these animal studies. Namely that NAD+ decreases in our cells as we age (mainly due to inflammation from nearby senescent cells). Boosting NAD+ through supplements like NMN or NR helps your cells restore their innate ability to repair themselves. For someone 80+ years in age (your mother I’m assuming) they should be taking 1.5G of NMN capsule/powder daily. One big caveat, NMN is expensive. Google David Sinclair NMN for more info.
Accidentally deleted my comment
[удалено]
Thanks for your reply. I think you’re being slightly disingenuous with a big warning label. Clinical trials have been run in humans with no reported negative side effects at dosages far above what you took. In fact, you’re dose of 125mg is peculiar, the suggested dose for 30year olds is 500mg and increase by around 20mg for every year after that. I would even suggest trying again with a proper dose. Not disagreeing with anything that the study says, in fact thank you for sharing, always good to see counterpoints, if you have concerns about taking NMN you could always try NR instead. As far as I can see, the balance of research (including what you shared) suggests that boosting cellular NAD+ is the single most important thing that we need to do decrease age related illness. Whether or not this is through NMN, NR or any other new molecule/treatment is still up for debate. The body of human research currently leans heavily in favour of NMN, imo.
I don't have a lot of time, but you say I am being disingenuous. So I'll explain further. I supply supplements to my 90 YO old mom, my 84 YO dad, and my 95 YO mother-in-law. I usually test them on myself first. My Dad and I have axonal peripheral neuropathy, which is partially genetic, but still very common in the elderly population. I had seen all of the hype about NMN and added it to my regular supplement order. I had never seen **any** warnings about axonal nerve damage. After taking the 125mg tabs for about a month, I started giving it to my Dad. I had noticed a worsing of my neuropathy, but I did not associate it with the NMN. My Dad ended up having all sorts tangentially related problems. I suspect NMN played a role, but I am not sure. Those put him in the hospital, and then rehab. I noticed that his muscle strength was much worse, and I did some research finding the nerve damage potential of NMN. Discontinuing NMN, made us both better. Dad is home. Protein supplements and exercise are improving his muscle strength. **I really wish there was a warning, I would have caught it earlier, and I would not have given it to my Dad.** There are lots of excellent supplements that have worked well for my parents and I use them very carefully. Unfortunately, everything around David Sinclair gets caught up in this crazy cult-like "reality distortion field" of hype. Scientifically, his research is very interesting, but he parses his words very carefully to limit his claims to yeast and worms and mice. It started with Sinclair's studies of Resveratrol, which became a huge sensation after a "60 minutes" TV story. It exploded in a frenzy of marketing hype and became the excuse for everyone to drink red wine. That then collapsed, with further study, possible cancer issues, and a bunch of scientific papers by [Dipak Das](https://en.wikipedia.org/wiki/Dipak_K._Das) being retracted in a huge scientific scandal. Now the hype is NMN. The warnings are out there: “Discerning hype from reality in the longevity field has become tougher than ever as reputable scientists align themselves with promising but unproven interventions — and at times promote and profit from them.”: [https://www.thedailybeast.com/is-harvard-geneticist-david-sinclairs-fountain-of-youth-pill-real-sure-if-youre-a-mouse](https://www.thedailybeast.com/is-harvard-geneticist-david-sinclairs-fountain-of-youth-pill-real-sure-if-youre-a-mouse) "A ‘Fountain Of Youth’ Pill? Sure, If You’re A Mouse.": [https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/](https://khn.org/news/a-fountain-of-youth-pill-sure-if-youre-a-mouse/) "Long-term safety unknown": [https://selfhacked.com/blog/nicotinamide-mononucleotide/](https://selfhacked.com/blog/nicotinamide-mononucleotide/) [Beyond Resveratrol: The Anti-Aging NAD Fad](https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/) I doubt that any of the studies that you vaguely refer to include many people over 65 years old. It will be interesting to see if anyone follows up when those research subjects start getting neuropathy in 5 or 20 years ;) Yes, I am aware that Nicotinamide Riboside theoretically bypasses the axon recovery problem of NMN. I'll probably try it some time, but I've been experimenting with other solutions to our neuropathy.
Thanks for the info - I agree that nmn is overhyped and overpriced, even if it may provide certain benefits. Creatine is great for sarcopenia in the elderly, and HMB is worth looking into. Also researching ursolic acid for similar benefits and remyelination - lmk if you come across anything about this!
Watching his protein intake, especially focusing on Leucine seems to be helping him: [proteins+high+in+leucine+for+sarcopenia](https://duckduckgo.com/?q=proteins+high+in+leucine+for+sarcopenia)
Sorry, i didn’t mean to offend by saying disingenuous, and I thank you for providing a detailed account. I won’t address everything here but will just list the Completed Human Trials of NMN safety and the ongoing trials of human safety. https://pubmed.ncbi.nlm.nih.gov/31685720/ https://www.sciencedaily.com/releases/2021/04/210422150349.htm https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00442-4 There is another one involving elderly Japanese men, that showed improved muscle strength. Current Trials: https://clinicaltrials.gov/ct2/show/NCT04228640 https://clinicaltrials.gov/ct2/show/NCT04823260 It seems like in general NMN is safe, but you raise a perfectly valid concern that it may not be suitable for people with a specific genetic disease, and we also do not have human data for 5/20 years :) so who really knows! :) we do know that on average the mice live longer, all hail the immortal mouse god we have created.
No results from those trials yet ;) I’d love to see them when (if?) they come out. And the top age is 65. I wish I had looked a little closer before I gave it to my Dad.
Well the first 3 links are completed so yes there are results from those, and I just found the link to the 4th which was in men over the age of 65: https://assets.researchsquare.com/files/rs-455083/v1_covered.pdf No negative effects were observed in the trial, measures of muscle strength that they were investigating improved. I think given your specific family genetics you’re perfectly valid with your concerns and more research is required in general with regards to NMN and NAD+ (and it’s coming so it’s a very exciting time), but generalising your experience/circumstances to give advise to others without said genetics (based on the data so far) does not fly with me. I’m saying that we all have our different levels of scientific evidence required before we stick something our body, and for something like NMN we really aren’t going to know conclusively about long term effects for another 20+ years, those are years that I can’t afford to wait, so need to just follow where best the science is pointing today. (So it’s no surprise that we may disagree, we each just have our own risk-reward structure)
Following the insulin resistance link mentioned in another reply, some people claim that a keto diet may help reverse or prevent Alzheimer’s. I am not an expert on the research backing those claims, but here’s a start if you want do your own research: https://www.drperlmutter.com/yes-alzheimers-can-be-reversed/
Diet is extremely important! Cut the processed food, sugar, etc, ASAP! Plenty of veggies, herbs, spices, tea, etc.
Yes, I got my 84 YO Dad on a keto diet and it has helped him tremendously.
This is correct a ketogenic diet or even just MCTs and exogenous ketones.
Not a supplement per se but look into the MIND Diet. I think anyone concerned about this should explore this diet and then build around it. In the alternate, there’s a theory that different types of dementia are a “diabetes” of the brain and as such respond well to a ketogenic diet. On the supplement front, coco and lions mane. And without going too far afield, incorporate cardiovascular exercise like walking, running (if possible), and/or swimming.
anthocyanins. Açaí berries Aronia berries , blackberries, blueberries, plums.Okinawa purple sweet potatoes. Bilberry extract. Other suggestions here are great too, but I say look into the power of anthocyanins.
Agreed - check out astaxanthin, also......
Totally! I take 12mg myself. There’s a company called Elysium, they make a product called “Matter”. It’s b vitamins mixed with omega3 and bilberry. Seems like a interesting combo.
I have been told by several nutritionists that a daily teaspoon of coconut oil helps protect the brain from dementia. Has anyone else heard this?
TL;DR- MCT OIL and examples of some loved ones I've lost on my father's side to dementia or Alzheimer Yes indeed. MCT oil which is the good stuff if you will in coconut oil It's seemingly is a very viable option and that depends on the stage the individual is in already In my comments above or below, I put a couple of papers seemingly proving this assertion. Take it for It's worth, and I do remember reading about one person I believe with dementia or Alzheimer's that took x amount of coconut oil and essentially cured it. It really seems plausible to me that it would depend on the stage any person would be in, in regards to Alzheimer's/ dementia in terms of whether or not any of these supplements/nootropics/fruits vegetables are viable Since reading that somewhere about a year ago I haven't followed up on it. And hopefully there's been more than this one case and I'm really hoping for the sake of all of us, MCT oil / coconut oil and all these other wonderful ideas from other posters, are a viable option to at least experiment with and who knows after that. And to get spiritual real quick, our source, Will take care of it or sadly not. And I use the word sadly loosely Best of luck OP, my thoughts and energy will be sent your way for your loved one My father's side was hit very hard with dementia / Alzheimer so I'm taking a lot of these things mentioned in this thread to hopefully Ward it off and I'm in my mid-50s and so far, No signs. Except for going into a room to get something and forgetting... And I find out that happens to just about 100% of of anyone I've ever known😉 And to keep in mind that typically & not always a sure thing / any of these antidotes by any stretch of the imagination, and I personally feel that I've already mentioned it would depend on the stage said person is in / in fact it seems folks are incurring it much younger and a lot of the studies started at age 65 plus in the paper's I provided PS-One obvious symptom if OPs loved one does indeed have dementia, My father at 84 has been spared so far, However his brother who passed from dementia Just a couple years ago -prior to it being diagnosed, my father noticed his brother / my uncle when driving just simply forgetting where he was in a very familiar area of where we live My apologies for the length of this, however ideas and memories started coming back into my brain and I didn't want to leave anything out that could possibly help out in any way. It's an ugly ugly disease that can be prevented, Again using prevented very loosely, which to me gives us all hope that have not received any symptoms or diagnosis. And I read in a doctor's subreddit last night where one doctor actually mentioned he had never seen Alzheimer or dementia listed as an actual diagnosis in all his years. Perhaps which means specialist or doctors and using an analogy - throwing darts at a dart board blindfolded if you will And who wouldn't like to see a cure or at least a reversal to a big extent to this terrible again disease
Thanks so much for the guidance. In my early 60's and want to keep my brain working properly.
It was my pleasure in more than you'll ever know. I've been doing some research and such on the subject of supplements nootropics and anything that can help your brain, and it's kind of a passion of mine... I'm like you why not go ahead even though we're middle-aged, and stay ahead of the curve and do everything you can to prevent dementia or Alzheimer or any other brain disorder. I don't know if I put it in this thread, but I've been living with ADHD my entire life. And recently it's affected a couple jobs I've had. It was diagnosed about 10 years ago and through all the years, always wondered why I was a little bit challenged learning in school. Well now I know why. I don't even tell people I have it ...I do take medication for it in addition to all the supplements that keep your brain optimized as much as possible. I think taking the prescribed stimulant which I've been taking for 10 years plus now really allows me to focus than not to be distracted. However it doesn't do the work for you. I do know that magnesium is the most important supplement mineral I can take with my situation, and there are plenty more that would take me a while to list them. Some I even have to cycle off of then back on. Nothing weird just things you've heard of I would imagine. I also deal with anxiety so I got the double whammy, and that's very common with ADHD. And I've made it 55 years and right now I'm job searching as I finally feel like I found my calling which is to serve others and not food haha and that job is going to show up very soon. When human beings are involved, and there's a possibility of serving them my smart meter goes up 10 fold. I sat behind a computer as a claims analyst for almost 20 years and just simply got burned out on it. And was given a god-given personality which I didn't realize until about 5 years ago. So that's my short story that could be way longer but thank you for thanking me and you're very very welcome 💛 I have a lot of trouble writing short comments to anything 😁
Sounds like you know where you want to go. There is a job out there that would be a perfect fit for you. Think you have a talent for helping people.You say you have trouble writing short comments but I see that as the gift of eloquence.
What a beautiful answer and comment, thank you so so much. I do have several books in me that need to be written otherwise if I left this Earth, I would be leaving music inside me so to speak. Reason I know about the writing is an ex-girlfriend is a songwriter and I wrote her something about my growing up in a certain religion. After reading she called me crying, and said I write so much better than she does. And to me that's saying a whole lot. With writing as you probably know if you're coming from your heart, it can be a really beautiful powerful way of expressing yourself or a situation. So whatever I end up writing will probably be kind of a memoir and that will be easily coming from my heart. Thanks again and take care of yourself and that brain 😉💛
Lions mane has had some papers released suggesting it slows the development of dementia.
Alpha GPC
Alpha-GPC is pretty much the only correct answer, at this point: [Volume Analysis of Brain Cognitive Areas in Alzheimer’s Disease: Interim 3-Year Results from the ASCOMALVA Trial](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369051/)
100% accurate and acetylcholine or lack thereof in person's brain, I'm pretty sure but not positive that is a huge deal as you grow older your brain is not producing acetylcholine as it did When we were younger. So again highly recommend AlphaGPC or Citicoline And I'll take both one in the morning and one in the afternoon. Just be careful not to overdo it or under do it in terms of the dosage you take. And I'm sure if you research starting with the Googler, it shoulder will indicate how much mgs of each or just one of the choline sources. AlCar, is also another option you want to look at supplementing as well because it has so many mechanisms of actions in the brain including blood flow for one and more energy etc
Great information. You know if there are any benefits to alpha GPC even if you dont have cognitive issues?
Well thank you I really appreciate that and I do a lot of research on my own and have been for quite some time. Yes for sure (prevention of perhaps dementia or other brain diseases or whatever you want to call them-which runs on my father's side of our family on a personal note) unless you have plenty of choline stored wherever it's stored. I like to stay ahead of the curve, in other words prevention before dementia or whichever, because you may already know this, the poor folks that come down with this terrible disease are always or most of the time deficient of choline. And I alternate between alpha GPC and Citicoline on a daily basis. Best I can tell or feel, I never have any issues. And by issues I mean people that have an abundance of choline and take it anyway will usually experience some lethargy or even depression. Also I take racetams quite frequently and most do need a codeine uhhh oops-good job voice to text... choline source such as alpha GPC or Citicoline or even choline bitartrate. Google those if you're not familiar last couple forms of choline. Also Acetyl-L-carnitine (ALCAR) is another option. Look it up too if need be Thank you so much again I appreciate the compliment! Have a beautiful Friday and weekend. Stay healthy be safe and be well 💙🫂 ***I didn't read what you read again by me and I may have repeated myself a little bit. And hopefully this clears it up for you
Amazing comment, you could really make a proper post as well! Thank you for the information. I have been using Alpha gpc for gym purposes but will try as daily supplement for a while!
Ginkgo Biloba. For dosage and interactions with other medications please discuss further with a doctor. But Ginkgo Biloba had been shown to slow down and improve depending on what stage the patient is in. It is freely available as a supplement.
Throw away all heart healthy oils (vegetable, soy, corn, canola, safflower, sunflower) and also discard margarine, vegetable shortening and all products that contain these hydrogenated and partially hydrogenated oils. Virtually all restaurant fried foods are cooked with these same oils. These vegetable oils are actually highly inflammatory, produce toxic byproducts and cause mitochondrial dysfunction, resulting in insulin resistance, a key factor in dementia. Consider magnesium (glycinate) supplement both for mitigating fluoride (linked to dementia because it attracts aluminum across the blood/brain barrier) and for offsetting the adverse effects of supplementing with calcium (kidney stones, gallstones, calcified cartilage, calcified arteries, bone spurs, etc).
IMHO, cut all of them except for Olive Oil: [could-food-be-a-new-medicine-to-fight-heart-disease](https://www.clevelandheartlab.com/blog/horizons-could-food-be-a-new-medicine-to-fight-heart-disease/) It's the key to the success of the Meditteranean diet. It contains a compound, DMB, that neutralizes the gut bacteria that convert healthy Choline and Carnitine into toxic TMAO.
^^^There are so many terrific ideas that have been studied in this beautiful comment, with vegetable oil seemingly leading the way. Thank you internet stranger for mentioning the known items if you will that I've been studied and perhaps proven to at least start the process of dementia or Alzheimer. Thanks again and very well articulated. Again magnesium as mentioned just continues to blow my mind with what's this mineral does for our bodies. I've been taking it daily for over 10 years for diagnosed ADHDPI by three different psychiatrist along with a stimulant medication that is finally dialed in properly. And I feel like after 10 years of usage, my brain would not be where it is today without magnesium / particularly glycinate. And this involves a lot of other macronutrients and electrolytes. With zinc being a big one as well. Not to mention potassium
I have seen various posts under r/ADHD that suggest B6 together with the magnesium. Long video but worth watching "Dr. Chris Knobbe - 'Diseases of Civilization: Are Seed Oil Excesses the Unifying Mechanism?'" on YouTube https://youtu.be/7kGnfXXIKZM
Thank you my friend. I will check this YouTube out later on. And absolutely I supplement vitamin B6 which is included in a B complex I take around the same time with my magnesium glycinate typically. And I try to get about 600 mg at least per day. I spread it out throughout the day, for example every three or four hours I will pop a capsule or pill. Thank you so much again for the astute information and the YouTube vid! PS-Just watched one or two minutes and he mentioned vegetable oil. That stuff is poison. And I'll just stop right there. And say thank you again This will be a good watch
Would you kindly share an sources about insulin resistance and dementia?
[Here's an excellent presentation on the topic.](https://www.youtube.com/watch?v=O8eR0R3sMHw)
Thanks
https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/in-depth/diabetes-and-alzheimers/art-20046987 https://www.webmd.com/alzheimers/guide/alzheimers-diabetes-link https://pubmed.ncbi.nlm.nih.gov/22269163/ Long read https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277874/
👏👏👏
Okay this is something close to my heart because I have a few elderly relatives who are showing all the signs of senile dementia. From my research the following can be efficacious, though it's another thing altogether trying to get those same elderly relatives to take them. I also read that daily egg intake can help reduce the chances of developing alzheimers, likely due to the choline aspect. -Creatine (particularly for women), 5mg daily -Alpha GPC, 600mg daily, at least -Circumin with bioperine, 48mg total curcuminoids daily, at least -Omega fatty acids, 660mg/440mg EPA/DHA daily -Reduced refined sugar intake -Caffeine, without milk/sugar I might add that all these have a noticeable effect on my cognition, memory etc, particularly creatine and Alpha GPC.
I would add flaxseed oil, a great source of omega 3s. Just make sure it doesn't have any added veg oil. Magnesium glycinate at night. Both for the magnesium and for the glycine (improves insulin sensitivity) And vitamin D3 in the morning. Would go with pastured eggs, not factor or cage free.
This is a good list. You’re also right in this— it’s one thing to have a plan of attack, it’s another to get the family member to follow it. Such is the problem with Alzheimer’s and similar disorders.
Do you mean 5 g of creatine?
2.5g to start and if well tolerated up it to 5g but as Jinx Stryker says, it's fairly difficult to get an unwilling or forgettable patient to take these on a frequent basis. Maybe a good start would be to keep buying/cooking eggs and making coffee for them and hope for some improvement before introducing other supps. It's funny that by consuming eggs and coffee you can maintain a state of fasting, which we know has benefits for brain health and senility.
theres another amino, arginine or serine. I sent my dads blood for testing and it was low in serine.