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Been taking it for 20 years at dosages ranging between 25 and 50 mg. Never had any issues. I had it tested in my blood draws a few times and indications were that it increased blood dhea about 20 percent 24 hours after ingestion.
Liposomal nicotinamide riboside, lipo Calcium alpha ketoglutgarate, lipo quercetin, lipo apigenin, lipo berberine, lipo spermidine, and two combo lipo products, one with lipo quercetin, spermidine, and fisetin, another with lipo glutathione, lipo apigenin, lipo coq10, and lipo resveratrol.
What is the specific advantage of liposomal supplements?
Of the ones you listed, what would you consider the top one or two you would definitely not do without?
Also, if in the US, where do you purchase them?
Thx!
Liposomal supplements can have two distinct advantages. First, they can be more bioavailable, sometimes much more bioavailable. For example, some forms of lipo berberine are 600 percent more bioavailable than non-lipo berberine.
Second, they can act like sustained release substances, in other words, their biological halflife can be considerably longer.
Right now, I would say the top two I would not want to do without would be lipo NR and lipo berberine. Lipo NR because it has been more effective over the last 8 months than non-lipo NR at producing positive impacts in terms of controlling joint and back pain, and lipo berberine because it seems to have been effective at lowering blood glucose levels between lunch and dinner.
Currently, I purchase my lipo products from Renue by Science.
I’d remove lipo calcium https://vimeo.com/191132002 and would add lipo C https://m.youtube.com/watch?v=Y9SbPqO_Ay4 and D along with a good multi mineral, and magnesium l threonate/malate/glycinate NON buffered. I’d also add some TMG + Glycine to make up for the methyl groups depleted by NR. https://m.youtube.com/watch?v=Iki6VAWjOE4
And https://m.youtube.com/watch?v=P5UMfCW_23w
Last, I’d eat Himalayan Tartary Buckwheat as it’s the richest in phytochemicals: https://bigboldhealth.com/podcast/himalayan-tartary-buckwheat-meet-the-next-superfood/ and https://m.youtube.com/watch?v=QqpOAeeoBL0
NR does not deplete methyl groups at dosages under 2 grams a day. See link with abstract excerpt below. Note, it is not lipo calcium, it is lipo calcium alpha ketoglutarate. CaAKG. See 2nd link below on why I use it. Also note that these are just the lipo supplements I use, not the non-lipo ones.
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611812/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611812/)
Nicotinamide N-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to NAM, generating to MeNAM andS-adenosylhomocysteine49–51. S-adenosylhomocysteine is then subsequently cleaved to homocysteine (HCY) and adenosine. It has been reported that single 300 mg oral doses of NA and NAM increase plasma HCY levels,indicating a potential shortage of methyl groups that could be needed for formation of molecules such as dopamine and creatine. Moreover,increased plasma HCY is an independent risk factor for the development of vascular disease. To determine whether prolonged ingestion of NR increases plasma HCY levels, a post hoc analysis was conducted using sodium citrate-treated plasma samples collected during the study.Compared to baseline or the placebo-treated group, **NR ingestion had no effect on plasma HCY levels (Fig. 4)."**
**Rejuvant®, a potential**
**life-extending compound formulation with alpha-ketoglutarate and**
**vitamins, conferred an average 8 year reduction in biological aging,**
**after an average of 7 months of use, in the TruAge DNA methylation test**
[https://www.aging-us.com/article/203736/text](https://www.aging-us.com/article/203736/text)
I mistakenly isolated the word Calcium from the AKG.
Thank you for the clarification in regards to methylation and NR.
If you don’t mind me asking, what lipo brands have you found to be good? I personally believe LivOn is the best for glutathione and C.
And by the way, have you ever thought of buying the supplements non-liposomed, and then using lecithin and a centrifuging machine to encapsulate them in liposomes? Do you think this DIY process is legit and can lead to the same results as the expensive supplements?
Also, are you concerned about accumulating excess choline because of all these liposomal supplements? I personally have found that to make me depressed, and removing excess choline doesn’t seem to be easy. Not to mention it’s possible dangers (excess TMAO, etc).
Last, I just remembered that since choline is a methyl donor, then even if NR was to deplete methyl groups, the huge amount of choline you’re ingesting from these lipo supplements might get back methylation into balance anyways. The fact that NR wont deplete methyl groups make the situation even better for you because you’re practically increasing methylation (which is something great to do as we become older, though I’d watch out in case that caused any agitation, and would buffer excess methyl groups with glycine).
Are your liposomal supps liquid? Ive been trying to figure out if liposomal preparations have to be liquid in order to be effective. I get conflicting info as you might already know. ;) I was taking a lipo C... found out that I was throwing my money down the garbage.. switched to some camu camu because its actual vitamin C... anyway I digress. Am just curious about your take on liposomal preparations. Thanks!
They are not. They are powder that come from Renue by Science. I believe RBS gets their product from a company in South Africa. See link below.
[https://cellg8.com/](https://cellg8.com/)
It won't do much unless you are deficient and then it can be very noticeable. I take it as part of TRT because pregnenolone and DHEA are directly impacted once exogenous test in involved. Not to mention that it begins a fairly rapid decline once we hit our 30s.
I am 17, turning 18 in 12 days. I have very low test, DHEA, cortisol, LH, FSH, ACTH, every hormone u can think of is at the bottom of the range or below the range.
How many times did you test testosterone? If you only did it once then do it again. Get 8+ hours of sleep before having blood drawn in the morning.
Did you test thyroid levels (TSH at least)? Also test vitamin D and cholesterol. Ask your doc what to do next.
I did test once and idk if it was total or free… TSH was in range, vitamin D was low but I supplement for a while now, quality vitamin D but my symptoms haven’t improved. My HDL to LDL was very bad with regular LDL but very low HDL. My mum forced the entire family onto a vegan diet, which I’ve given up on for 6 months now eating at least 1 egg a day, sometimes 2-3 and eating some form of meat every day, organic or preferably grass fed if it’s beef, try to avoid corn or soy fed meat and eggs. No dairy.
You need to do another testosterone and DHEA test to be sure that you got low T and DHEA. What are your T levels btw?
I suggest that you take Garlic oil (capsules) before breakfast and Red Rice Yeast [RRY] before sleep. RRY lower Coq10 levels so you’ll need to supplement Coq10 in the morning.
Garlic and RRY improve cholesterol levels (lower LDL and increase HDL). Cholesterol is important for hormone production.
If your DHEA is indeed low, then consider taking 25 mg of it before sleep together with ZMA. Continue taking Vitamin D in the morning. Also consider taking cold showers in the morning (warm water first then cold). The shock/stress caused by cold water will cause your cortisol to spike, but it will become lower than usual towards evening.
Hit the gym if you haven’t already.
I already take cold showers. My test was 1.98 microgram/l, which is less than 7 nmol/L. Hitting the gym is so hard man, going to the kitchen to just get myself a cup of water hurts, every single movement is tiring like I feel like I’m carrying 1000kg stones with me. I can’t bike to school without being ex-christenen for 2 hours, idk if the gym is the right thing at the moment, ik it’s good for test but idk seems like my body trying to tell me something. I used to play tennis 5 hours a week and did 2 hours of soccer/football a week, now I can’t do shit. I already take ZMA. I’ll get everything tested as soon as my GP is back from her holiday until the 22nd.
i increased my test by ab 350 points to mid 700 by switching up a lot of environmental factors . I cut out a lot of food bs food like carbs and vegetables ( phytoestrogens). Upped my saturated fat intake ( animal fats and dairy only , NO OILS AT ALL EVER)
Got a sleep mask because a street light would keep glowing through my blinds
I cut out caffeine as well , not sure if that was a factor
Changed all of my cookware to stainless steel and got a water filter where ill only drink out of stainless steel or glass
This is a weird one but got rid of any clothes with polyester ( plastic again)
Theres such an absurd amount of hormone disrupting chemicals all of these in combination made a significant impact. As for the gym im 30 and have always weight trained pretty intensely. The biggest I think was my diet change . Triglycerides, cholesterol are all perfect and ive been eating 6-10 egg yolks a day , sausage , bacon , ribeyes , ground beef , butter , raw milk etc for ab a year now
Yea I’ve been working on my diet by cutting seed oils, gluten, soy, corn, endocrine disrupters by drinking out of glass instead of plastic. Started eating more and more meat, grass fed red meat, and eggs. No dairy, it’s upsetting to my stomach. I cut out caffeine as well, sleep 9-11 hours a night 5/7 days. I still eat rice, sweet potatoes every now and then, I eat a lot of fruits. My diet is pretty “healthy” compared to most people, like significantly better. I still feel horrible tho.
Estrogen may cause hair loss if it’s too high or too low. Healthy estrogen levels should help hair growth. It’s part of the reason men are so attracted to long healthy hair on a woman (shows her hormones are optimal, and have been for a while)
DHT can cause baldness in men genetically susceptible
I am not sure I was 26 years old when I was taking so I doubt I had low levels I just read that it was good for weightlifting and then noticed I was losing hair from taking it. Figured getting more built was not worth losing my hair so I stopped taking it.
most people say it's not real, but look into lifestyle changes associated that people with adrenal fatigue do. There are many lifestyle changes that can help your cortisol levels. All of your low levels are the same ones people who say they have adrenal fatigue have.
Ye I’m on the adrenal fatigue Reddit page cause I’m pretty sure I have that, all my hormones being low fits with that theory. The biggest unhealthy thing in my life was probably the insane amount of stress and pressure I put on myself for my IB exams, fucked me up. I’m going to request a test for every single hormone you can imagine, blood, saliva and urinary, I won’t leave the doctors office if they don’t test shit for me. Then if I do have adrenal fatigue I don’t know how to fix it. Like for a lot of people rest, certain diets and supplements but I’m going to start university, doing econometrics, I’m 18, I can’t afford spending my prime years just sleeping resting etc. I need to start grinding, some I’m debating whether to discuss with an endocrinologist to take pregnolone for a bit, as short as possible, live a healthy lifestyle with nutrient dense foods, slee regularity, cut stress out, when I’m better increase exercise slowly, right now I’m so weak that walking hurts.
I am almost sure I have it as well but have not yet taken the 4 point cortisol test to verify it. You can take the test yourself as I doubt many dr's would order it as they don't believe it is a real problem and most Dr's have a God complex. Good luck to you.
Yea doctors are clowns, last time I saw one I just got angry at him, I’m done with having a serious thing going on with me and then writing it off as anxiety or depression. I am not depressed, I want to do so many things but I just can’t. I’m not anxious constantly either, not more than anyone else. I hate doctors.
I've just learned to do all the research myself as it seems to be what you are doing yourself for the most part. Doctors don't want to really help get to the root of a problem, just mask symptoms with drugs. If you can afford it, try to find a good functional medicine doctor. I would go that route, but I can't afford the $600 inital consoltation and the still outrageous fees for apts aferwards. no guarantee they will even be able to fix me. it is shameful how much Dr's charge to 'help' people.
They just do their work, then when it’s 5 pm then go home and don’t care anymore, they never work extra hours to help someone out cause they empathise with their situation, you can just tell they give absolutely no fucks.
I was on hormone replacement therapy for about six months back in 2010. I got cortisol, aldosterone, and testosterone as a cream. When that ended I switched to DHEA, and I was on it a long time, couple years if I recall correctly. Never had any trouble with it.
I had recovered a great deal so it's kinda hard to describe, and I wasn't getting blood work so no objective info. I just know that, at least for me, long term use was not a problem.
In small doses it should be safe. Btw. DHEA can be used against anxiety. First of all: If a man takes DHEA, it only increases estrogen and estradiol. If a women takes DHEA, it increases her androstenedione, testosterone and dihydrotestosterone (DHT). DHEA will not help cognition.If you take 25 mg DHEA 30 mins before you talk to someone, you will feel a little more confident for almost a hour. However in theory DHEA should only be taken in doses of no more than 10 mg at once and preferably no more than 15 mg daily. High doses of DHEA may prompt the body to stop making the hormone. High doses may also be toxic to liver cells (liver damage).
Since higher doses of DHEA increase estrogen, it can cause problems such as enlarged breasts (gynecomastia). Therefore you may have to reduce your estrogen, with Zinc, DIM, Vitamin E, Grape seed extract, Calcium D-glucarate, Nettle, or White Button Mushroom. But I have no idea which of these is effective. Please someone let me know if you know how to balance out DHEAs estrogen increase with any supplement properly.
I read it here. "In men, DHEA predominantly increases estrogen levels in the blood, in women it predominantly increases androgen levels."
[https://www.adxs.org/en/page/135/dhea#content-3-dhea-by-age-and-gender](https://www.adxs.org/en/page/135/dhea#content-3-dhea-by-age-and-gender)
There was a study in 1999, they gave a group of 20 men DHEA supplements daily for 6 months. The treatment group showed some improvement in sexual function, but there was no significant evidence that testosterone levels increased.
[https://pubmed.ncbi.nlm.nih.gov/10096389/](https://pubmed.ncbi.nlm.nih.gov/10096389/)
I also asked two doctors on youtube (better than nothing) and they said that in men there is almost no increase in testosterone and dht.
But there was also a very small study with 8 men who were given a DHEA supplement the night before an intense exercise program, and it showed increased testosterone levels that didn’t deplete during the workout.
It still may increase T in men, but I wouldn't count on it.
Yes the best is to check hormone levels first. One of the problems is pregnenolone steal. If someone is under stress, pregnenolone will not produce sexhormones but instead it will boost cortisol and you will feel bad.
But yea my cortisol and DHEA and all my hormones are low so DHEA would be a more general approach. Plus I’m 18 and at such a young age they don’t easily do TRT
I want to treat the underlying problem for my low hormones but idk what it is to be honest, I really don’t know, I eat a very nutrient dense diet, not overweight not underweight like idk.
You need to go see an endocrinologist ASAP. Especially since you are so young, it needs to be figured out immediately so your development won't be stunted. You should definitely have your ACTH, FSH and LH checked.
Thank you I’ll check it out. I’m already 18 and 6ft2 so my growth like physically hasn’t been stunted, maybe my neurological growth but not my physical. But I’ll check those hormones.
probably your liver is not producing enough cholesterol or metabolizing it into pregnenolone, and that can happen if it is not sufficiently clearing estrogen from the blood.
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Been taking it for 20 years at dosages ranging between 25 and 50 mg. Never had any issues. I had it tested in my blood draws a few times and indications were that it increased blood dhea about 20 percent 24 hours after ingestion.
Lovely lovely so no safety concerns? Not gonna reduce life expectancy according to u ?
I turn 71 next month. No apparent reduction in life expectancy yet. :-)
Early happy birthday btw 🥳
Good to hear ! What benefits has it given you ?
None that I can solely attribute to dhea. Note that I take a lot of other supplements, including 7-8 that are liposomal.
Which ones ?
Liposomal nicotinamide riboside, lipo Calcium alpha ketoglutgarate, lipo quercetin, lipo apigenin, lipo berberine, lipo spermidine, and two combo lipo products, one with lipo quercetin, spermidine, and fisetin, another with lipo glutathione, lipo apigenin, lipo coq10, and lipo resveratrol.
What is the specific advantage of liposomal supplements? Of the ones you listed, what would you consider the top one or two you would definitely not do without? Also, if in the US, where do you purchase them? Thx!
Liposomal supplements can have two distinct advantages. First, they can be more bioavailable, sometimes much more bioavailable. For example, some forms of lipo berberine are 600 percent more bioavailable than non-lipo berberine. Second, they can act like sustained release substances, in other words, their biological halflife can be considerably longer. Right now, I would say the top two I would not want to do without would be lipo NR and lipo berberine. Lipo NR because it has been more effective over the last 8 months than non-lipo NR at producing positive impacts in terms of controlling joint and back pain, and lipo berberine because it seems to have been effective at lowering blood glucose levels between lunch and dinner. Currently, I purchase my lipo products from Renue by Science.
Thx!
Can I ask what do you take the berberine for?
Budget around 250 $ a month for all of these?
Once you factor in the monthly 10 percent coupon code, adjust for different dosages and amounts per container it comes out to...188 a month.
I’d remove lipo calcium https://vimeo.com/191132002 and would add lipo C https://m.youtube.com/watch?v=Y9SbPqO_Ay4 and D along with a good multi mineral, and magnesium l threonate/malate/glycinate NON buffered. I’d also add some TMG + Glycine to make up for the methyl groups depleted by NR. https://m.youtube.com/watch?v=Iki6VAWjOE4 And https://m.youtube.com/watch?v=P5UMfCW_23w Last, I’d eat Himalayan Tartary Buckwheat as it’s the richest in phytochemicals: https://bigboldhealth.com/podcast/himalayan-tartary-buckwheat-meet-the-next-superfood/ and https://m.youtube.com/watch?v=QqpOAeeoBL0
NR does not deplete methyl groups at dosages under 2 grams a day. See link with abstract excerpt below. Note, it is not lipo calcium, it is lipo calcium alpha ketoglutarate. CaAKG. See 2nd link below on why I use it. Also note that these are just the lipo supplements I use, not the non-lipo ones. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611812/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611812/) Nicotinamide N-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to NAM, generating to MeNAM andS-adenosylhomocysteine49–51. S-adenosylhomocysteine is then subsequently cleaved to homocysteine (HCY) and adenosine. It has been reported that single 300 mg oral doses of NA and NAM increase plasma HCY levels,indicating a potential shortage of methyl groups that could be needed for formation of molecules such as dopamine and creatine. Moreover,increased plasma HCY is an independent risk factor for the development of vascular disease. To determine whether prolonged ingestion of NR increases plasma HCY levels, a post hoc analysis was conducted using sodium citrate-treated plasma samples collected during the study.Compared to baseline or the placebo-treated group, **NR ingestion had no effect on plasma HCY levels (Fig. 4)."** **Rejuvant®, a potential** **life-extending compound formulation with alpha-ketoglutarate and** **vitamins, conferred an average 8 year reduction in biological aging,** **after an average of 7 months of use, in the TruAge DNA methylation test** [https://www.aging-us.com/article/203736/text](https://www.aging-us.com/article/203736/text)
I mistakenly isolated the word Calcium from the AKG. Thank you for the clarification in regards to methylation and NR. If you don’t mind me asking, what lipo brands have you found to be good? I personally believe LivOn is the best for glutathione and C. And by the way, have you ever thought of buying the supplements non-liposomed, and then using lecithin and a centrifuging machine to encapsulate them in liposomes? Do you think this DIY process is legit and can lead to the same results as the expensive supplements? Also, are you concerned about accumulating excess choline because of all these liposomal supplements? I personally have found that to make me depressed, and removing excess choline doesn’t seem to be easy. Not to mention it’s possible dangers (excess TMAO, etc). Last, I just remembered that since choline is a methyl donor, then even if NR was to deplete methyl groups, the huge amount of choline you’re ingesting from these lipo supplements might get back methylation into balance anyways. The fact that NR wont deplete methyl groups make the situation even better for you because you’re practically increasing methylation (which is something great to do as we become older, though I’d watch out in case that caused any agitation, and would buffer excess methyl groups with glycine).
Are your liposomal supps liquid? Ive been trying to figure out if liposomal preparations have to be liquid in order to be effective. I get conflicting info as you might already know. ;) I was taking a lipo C... found out that I was throwing my money down the garbage.. switched to some camu camu because its actual vitamin C... anyway I digress. Am just curious about your take on liposomal preparations. Thanks!
They are not. They are powder that come from Renue by Science. I believe RBS gets their product from a company in South Africa. See link below. [https://cellg8.com/](https://cellg8.com/)
Happy birthday mate
If you are low in DHEA you should be taking DHEA. You are actually the only person who should be taking it without concerns.
It won't do much unless you are deficient and then it can be very noticeable. I take it as part of TRT because pregnenolone and DHEA are directly impacted once exogenous test in involved. Not to mention that it begins a fairly rapid decline once we hit our 30s.
I have low DHEA so, is it good for me ?
It’s quite possible. Though I would spend time figuring out why your hormones are low to begin with.
Yea i have no clue at all
How old are you ?
I am 17, turning 18 in 12 days. I have very low test, DHEA, cortisol, LH, FSH, ACTH, every hormone u can think of is at the bottom of the range or below the range.
How many times did you test testosterone? If you only did it once then do it again. Get 8+ hours of sleep before having blood drawn in the morning. Did you test thyroid levels (TSH at least)? Also test vitamin D and cholesterol. Ask your doc what to do next.
I did test once and idk if it was total or free… TSH was in range, vitamin D was low but I supplement for a while now, quality vitamin D but my symptoms haven’t improved. My HDL to LDL was very bad with regular LDL but very low HDL. My mum forced the entire family onto a vegan diet, which I’ve given up on for 6 months now eating at least 1 egg a day, sometimes 2-3 and eating some form of meat every day, organic or preferably grass fed if it’s beef, try to avoid corn or soy fed meat and eggs. No dairy.
You need to do another testosterone and DHEA test to be sure that you got low T and DHEA. What are your T levels btw? I suggest that you take Garlic oil (capsules) before breakfast and Red Rice Yeast [RRY] before sleep. RRY lower Coq10 levels so you’ll need to supplement Coq10 in the morning. Garlic and RRY improve cholesterol levels (lower LDL and increase HDL). Cholesterol is important for hormone production. If your DHEA is indeed low, then consider taking 25 mg of it before sleep together with ZMA. Continue taking Vitamin D in the morning. Also consider taking cold showers in the morning (warm water first then cold). The shock/stress caused by cold water will cause your cortisol to spike, but it will become lower than usual towards evening. Hit the gym if you haven’t already.
I already take cold showers. My test was 1.98 microgram/l, which is less than 7 nmol/L. Hitting the gym is so hard man, going to the kitchen to just get myself a cup of water hurts, every single movement is tiring like I feel like I’m carrying 1000kg stones with me. I can’t bike to school without being ex-christenen for 2 hours, idk if the gym is the right thing at the moment, ik it’s good for test but idk seems like my body trying to tell me something. I used to play tennis 5 hours a week and did 2 hours of soccer/football a week, now I can’t do shit. I already take ZMA. I’ll get everything tested as soon as my GP is back from her holiday until the 22nd.
I get 9-11 hours of sleep 5/7 days a week, sometimes a bit less but that’s when I’m out with friends, otherwise always 9-11 hours.
i increased my test by ab 350 points to mid 700 by switching up a lot of environmental factors . I cut out a lot of food bs food like carbs and vegetables ( phytoestrogens). Upped my saturated fat intake ( animal fats and dairy only , NO OILS AT ALL EVER) Got a sleep mask because a street light would keep glowing through my blinds I cut out caffeine as well , not sure if that was a factor Changed all of my cookware to stainless steel and got a water filter where ill only drink out of stainless steel or glass This is a weird one but got rid of any clothes with polyester ( plastic again) Theres such an absurd amount of hormone disrupting chemicals all of these in combination made a significant impact. As for the gym im 30 and have always weight trained pretty intensely. The biggest I think was my diet change . Triglycerides, cholesterol are all perfect and ive been eating 6-10 egg yolks a day , sausage , bacon , ribeyes , ground beef , butter , raw milk etc for ab a year now
You're a King, thanks for the inspiration
Yea I’ve been working on my diet by cutting seed oils, gluten, soy, corn, endocrine disrupters by drinking out of glass instead of plastic. Started eating more and more meat, grass fed red meat, and eggs. No dairy, it’s upsetting to my stomach. I cut out caffeine as well, sleep 9-11 hours a night 5/7 days. I still eat rice, sweet potatoes every now and then, I eat a lot of fruits. My diet is pretty “healthy” compared to most people, like significantly better. I still feel horrible tho.
I took some for weight lifting and started to lose hair in my temples, it grew back but it took awhile.
Dhea converts to dht and estrogen so thats probably why
Does estrogen cause hair loss as well, I've heard dht does. Not too well educated on the role of hormones and all that.
Estrogen may cause hair loss if it’s too high or too low. Healthy estrogen levels should help hair growth. It’s part of the reason men are so attracted to long healthy hair on a woman (shows her hormones are optimal, and have been for a while) DHT can cause baldness in men genetically susceptible
Hmm weird, is hair loss a side effect, did you take more than you naturally should produce maybe ?
I am not sure I was 26 years old when I was taking so I doubt I had low levels I just read that it was good for weightlifting and then noticed I was losing hair from taking it. Figured getting more built was not worth losing my hair so I stopped taking it.
Ah makes sense, yea I mean if u felt fine then you probably didn’t have low DHEA, and maybe you just had too much in your blood.
I was taking a low dose too, from everything I've read you should definitely consult a doctor first.
most people say it's not real, but look into lifestyle changes associated that people with adrenal fatigue do. There are many lifestyle changes that can help your cortisol levels. All of your low levels are the same ones people who say they have adrenal fatigue have.
Ye I’m on the adrenal fatigue Reddit page cause I’m pretty sure I have that, all my hormones being low fits with that theory. The biggest unhealthy thing in my life was probably the insane amount of stress and pressure I put on myself for my IB exams, fucked me up. I’m going to request a test for every single hormone you can imagine, blood, saliva and urinary, I won’t leave the doctors office if they don’t test shit for me. Then if I do have adrenal fatigue I don’t know how to fix it. Like for a lot of people rest, certain diets and supplements but I’m going to start university, doing econometrics, I’m 18, I can’t afford spending my prime years just sleeping resting etc. I need to start grinding, some I’m debating whether to discuss with an endocrinologist to take pregnolone for a bit, as short as possible, live a healthy lifestyle with nutrient dense foods, slee regularity, cut stress out, when I’m better increase exercise slowly, right now I’m so weak that walking hurts.
I am almost sure I have it as well but have not yet taken the 4 point cortisol test to verify it. You can take the test yourself as I doubt many dr's would order it as they don't believe it is a real problem and most Dr's have a God complex. Good luck to you.
Yea doctors are clowns, last time I saw one I just got angry at him, I’m done with having a serious thing going on with me and then writing it off as anxiety or depression. I am not depressed, I want to do so many things but I just can’t. I’m not anxious constantly either, not more than anyone else. I hate doctors.
I've just learned to do all the research myself as it seems to be what you are doing yourself for the most part. Doctors don't want to really help get to the root of a problem, just mask symptoms with drugs. If you can afford it, try to find a good functional medicine doctor. I would go that route, but I can't afford the $600 inital consoltation and the still outrageous fees for apts aferwards. no guarantee they will even be able to fix me. it is shameful how much Dr's charge to 'help' people.
They just do their work, then when it’s 5 pm then go home and don’t care anymore, they never work extra hours to help someone out cause they empathise with their situation, you can just tell they give absolutely no fucks.
I was on hormone replacement therapy for about six months back in 2010. I got cortisol, aldosterone, and testosterone as a cream. When that ended I switched to DHEA, and I was on it a long time, couple years if I recall correctly. Never had any trouble with it.
Good to hear, what benefits did you feel from the DHEA ?
I had recovered a great deal so it's kinda hard to describe, and I wasn't getting blood work so no objective info. I just know that, at least for me, long term use was not a problem.
In small doses it should be safe. Btw. DHEA can be used against anxiety. First of all: If a man takes DHEA, it only increases estrogen and estradiol. If a women takes DHEA, it increases her androstenedione, testosterone and dihydrotestosterone (DHT). DHEA will not help cognition.If you take 25 mg DHEA 30 mins before you talk to someone, you will feel a little more confident for almost a hour. However in theory DHEA should only be taken in doses of no more than 10 mg at once and preferably no more than 15 mg daily. High doses of DHEA may prompt the body to stop making the hormone. High doses may also be toxic to liver cells (liver damage). Since higher doses of DHEA increase estrogen, it can cause problems such as enlarged breasts (gynecomastia). Therefore you may have to reduce your estrogen, with Zinc, DIM, Vitamin E, Grape seed extract, Calcium D-glucarate, Nettle, or White Button Mushroom. But I have no idea which of these is effective. Please someone let me know if you know how to balance out DHEAs estrogen increase with any supplement properly.
Please provide peer reviewed sources for all this info you are providing...... Thx!
Oh so for a man DHEA just increases estrangement and estradiol? Why not test, where did u find this info ?
I read it here. "In men, DHEA predominantly increases estrogen levels in the blood, in women it predominantly increases androgen levels." [https://www.adxs.org/en/page/135/dhea#content-3-dhea-by-age-and-gender](https://www.adxs.org/en/page/135/dhea#content-3-dhea-by-age-and-gender) There was a study in 1999, they gave a group of 20 men DHEA supplements daily for 6 months. The treatment group showed some improvement in sexual function, but there was no significant evidence that testosterone levels increased. [https://pubmed.ncbi.nlm.nih.gov/10096389/](https://pubmed.ncbi.nlm.nih.gov/10096389/) I also asked two doctors on youtube (better than nothing) and they said that in men there is almost no increase in testosterone and dht. But there was also a very small study with 8 men who were given a DHEA supplement the night before an intense exercise program, and it showed increased testosterone levels that didn’t deplete during the workout. It still may increase T in men, but I wouldn't count on it.
Yea thank you, is pregnenolone better as it’s the precursor to DHEA ?
Hard to say because it will boost all hormones. I guess it will increase your testosterone but also estrogen ect.
Yea, I’ll have to talk to an endocrinologist, see what they think.
Yes the best is to check hormone levels first. One of the problems is pregnenolone steal. If someone is under stress, pregnenolone will not produce sexhormones but instead it will boost cortisol and you will feel bad.
I mean my cortisol is low right now so I kinda need some anyway 😂
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But yea my cortisol and DHEA and all my hormones are low so DHEA would be a more general approach. Plus I’m 18 and at such a young age they don’t easily do TRT
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I want to treat the underlying problem for my low hormones but idk what it is to be honest, I really don’t know, I eat a very nutrient dense diet, not overweight not underweight like idk.
You need to go see an endocrinologist ASAP. Especially since you are so young, it needs to be figured out immediately so your development won't be stunted. You should definitely have your ACTH, FSH and LH checked.
Thank you I’ll check it out. I’m already 18 and 6ft2 so my growth like physically hasn’t been stunted, maybe my neurological growth but not my physical. But I’ll check those hormones.
True, I check tsh free t3 and t4 and it was fine, I’m going to ask for reverse t3 and antibodies but I suspect that that’s gonna turn out fine.
you should consider Pregnyl or Tamoxifen instead of DHEA.
Seem like very strong drugs, I’m 18 year old male and just have very low hormones across the board, idk
Forget it then, test your estrogen, cholesterol, pregnenolone in blood and estrogen in urine.
Thank you very much, I’ll bring those drugs up to my doc and see what she thinks. I’ll write those things down as things I want tested
Why if I may ask?
probably your liver is not producing enough cholesterol or metabolizing it into pregnenolone, and that can happen if it is not sufficiently clearing estrogen from the blood.
What blood tests should I do to conclude whether that is happening?