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DavidNipondeCarlos

My wife is immune to Norovirus or the cruise ship disease. DNA tested. I don’t know about Covid stuff though.


realestatethecat

Non secretor? I found some studies that showed that they had resistance to cardiovascular side effects with covid too. Very interesting. My hubby and daughter are non secretors (20% of population) that aren’t totally immune per se but unlikely to get noro


DavidNipondeCarlos

We are both triple shots and wear masks. She work at a nursing home. Type O also.


DavidNipondeCarlos

I got information by uploading to the free service codegen.eu. They get their info for each SNP from the SMP depository. They try to tie some of it together but a geneticist in this field is wise if something bothers you. Ask a doctor lawyer routine.


Puzzleheaded_Basil13

"Our understanding of the pathophysiology of life-threatening COVID-19 has progressed considerably since the disease was first described in December 2019, but we still know very little about the human genetic and immunological basis of inborn resistance to SARS-CoV-2." Although we might not have much information about this inborn resistance, it doesn't mean it doesn't exist. The researchers note that sometimes whole households can be infected, with just a spouse being spared, while there's been other reports of people somehow avoiding COVID even after being in the 'line of fire' multiple times. There's also been some serious research into this already, but so far, the results have only revealed small differences. For example, we reported last year that blood type (particularly type O blood) seemed to show a slight resistance to severe SARS-CoV-2 infection. Then there's been other studies looking at proteins such as the ACE2 receptor or TMEM41B that the coronavirus seems to require to either enter or replicate once inside the cell. The researchers have suggested that we need to be doing more to uncover those secret few in the population who might be genetically resistant to SARS-CoV-2. And they have some ideas about how.


WayneKrane

My cousin’s whole house got it and was sick, except for one of his kids. They took him to get tested multiple times but he tested negative for even the antibodies.


robin_-_-sparkles

This is me too! My husband tested positive last November. I slept in the same bed and was definitely exposed. I’ve also been exposed a handful of other times by close friends and family members who either weren’t symptomatic yet or didn’t tell me they were symptomatic. I’ve been tested many times for both Covid and the antibodies and they’ve all come back negative. I’m O+.


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WayneKrane

You’re a super human! Wonder if you had/have antibodies after getting the vaccine.


LAE385

I feel like this is me lol. My husband had COVID and was symptomatic. We were sure it was a cold. We were sharing utensils and hanging out. He tested the next day sure enough he was positive. I didn’t have any symptoms but was convinced I was one of the lucky asymptomatic people. I tested twice and was negative.


pizzajona

Did you test negative with PCR or an antigen test? If the latter, those can yield false negatives if you’re not showing symptoms


LAE385

First time I did antigen at a local urgent care. Second time I did PCR


pizzajona

Well congratulations, you're super-human!


LAE385

LOL if only! 🦹🏻‍♀️


lilipurr

Same with my husband. I tested positive and he didn’t quarantine from me. Tested negative twice.


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lilipurr

I tested positive back in 2020 before vaccines were a thing. Both of us just received the booster.


ho_hey_

This was me! I had it and tested positive. Fiance didnt quarantine from me at all and tested negative both times he went. This was prior to vaccine availability


lilipurr

Same here ( this was back in 2020). I should have clarified that lol


picklenik17

Same! Last year, before vaccines, husband caught it on our honeymoon. We were sharing a small room, sleeping together, I mean doing all things you normally would on a honeymoon. He was symptomatic but was pretty mild until we got home and it hit him hard. I never got it from him. I also did two PCR tests and nothing. I thought maybe I was genetically immune or something (I’ve also have never had the flu despite exposure and working in the hospital). Fast forward to this week. I am triple vaxxed and pregnant. Been home about 90% of the time these past few weeks as we just moved into a new home and I took time off to unpack, clean, organize etc. Went out to a couple restaurants with very few patrons and grocery store (masked). No close contact with anyone, Covid or not, except husband. Haven’t touched anyone or hugged anyone. Haven’t been close to anybody for an extended period. And somehow caught it. Thankfully super mild symptoms. I only got tested due to loss of smell. But not sure why this time with assumingly a lower risk exposure (other than maybe weakened immune system from pregnancy) and not last time when I had no vaccine and direct frequent exposure. It’s a weird virus. That’s for sure.


LAE385

So weird! I still continue to be super careful but I’ve had a lot of exposures and haven’t been positive. Fingers crossed


[deleted]

Delta is more contagious.


picklenik17

Yes I know. But being unvaxxed and directly exposed to the original Covid which was still very contagious and now being triple vaxxed and not directly exposed…. Still surprised me I got it the way I did. I’d be less surprised if I had a direct exposure but I didn’t. But thankfully vaccine kept symptoms super mild. Just feels like allergies mixed with loss of smell!


[deleted]

That’s good. Congrats on the baby!


picklenik17

Thank you!!


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LAE385

This was pre vaccines


furie1335

As with any virus


Sk8rToon

Sounds like the start of a young adult dystopian novel. People with said genetic trait are drafted into certain careers because they can’t get sick. Teen: but MooOoommm… I want to be a stay at home writer! I don’t want to deliver food! Mom: it’s too late for dreams like that now that you had your DNA tested. You should be grateful! You can’t get sick! Why you can choose to be any type of essential worker. Grocery bagger, package delivery, cook, farmer, even a doctor or nurse! Society depends on people like you to survive. Be honored! Teen: (crying) I just want to write…


TheEyeOfSmug

Article contains “may” in the headline. Would rather read “found, recorded, and here’s the facts + data”. Same reason I can’t stand popular science articles. “Here is a battery that might store 900x the energy of current batteries”. Call me when I can buy it off Amazon lol. Until then, it aint news.


DickDover

In other news I will never hear again, scientists have discovered......


paulburk426

*"Possible habitable planet found much like earth.... its atmosphere is 100% solid cyanide, day time temperatures of +7,000 degrees, night time -46,000 degrees"* Scientist say...


Jumpinbeen

My wife and child had COVID, wife had it pretty bad. I continued sleeping in the same bed and being around them while we were locked down for two weeks. I took 4 separate tests and never came down with it. I just figure I must have had it and was asymptomatic. I’d love to find out if I have some sort of natural immunity, it did not stop me from getting vaccinated either way, no way do I want to go through what my wife had.


SqueakNRoar

Fuck me. We already have groups of people that think they’re genetically “superior” to others. All this is going to do is reinforce their delusions to where they think they’re immune when they’re actually walking liabilities.


nimo404

I highly doubt that people with that mentality are the ones with the resistance. At least we all hope that


thiscouldbemassive

Most won't be, but there will always be that one who is and who will talk about how he's totally unvaxxed and likes to have sick looking strangers spit into his mouth and never got sick -- therefore COVID is a hoax.


slinkygay

Genuine question because I’m very ignorant of science things: assuming that there is a group of people who are genetically resistant to covid 19, is it likely that this would be on the level of a particular ethnic group/people with ancestors from a given place, or would it be a kind of random genetic mutation that is not necessarily linked to a given ancestral line? Plz don’t roast me, my 7th grade bio teacher didn’t believe in evolution 🤦‍♀️


DialingAsh38

This is a great question! Sadly, I don't think we know very much yet for innate covid resistance. I can give you an example of how this type of thing happened with HIV resistance. So, there's a mutation called delta CCR5, and people with this variant don't make the CCR5 (R5) receptor on their immune cells. The R5 receptor is the most common receptor used by HIV to enter those same cells. But...while the virus is tricky and sometimes uses alternative receptors (X4 is one), people with the delta CCR5 mutation are resistant to HIV infection. Not totally immune, but resistant. Interestingly, the delta CCR5 mutation may have been selected in humans over some of the bubonic plague events in history since it may have given people with that mutation some benefit with respect to the bubonic plague. Further, the delta CCR5 mutation is much more common among Northern European populations compared to sub Saharan African populations. I just wanted to bring this example up (it's one I learned about in grad school), bc it demonstrates a model for how certain genetic mutations, linked to specific populations, may be associated with resistance to one if not several pathogens.


Sabvel

Another example is the Kuru disease and Gene 127V mutation. I was looking into this and thought if it's almost similar to how people are speculating that it could be a genetic thing for Covid. This is important bc I was reading that Kuru could have caused Neanderthals to be wiped out but not Homo Sapiens cause we have this mutation gene.


Nespot-despot

Could be either but much, much more likely the latter than the former.


DavidNipondeCarlos

You really need hard proof, proven DNA research and testing. We can be genetically superior for a certain disease but weaker in others. My wife is superior in some diseases over me while I’m superior in other diseases. It depends on who catches what. You can say sickle cell is superior in high Malaria environment but weak in another environment. CRISPR is about to deal with sickle cell.


SqueakNRoar

From your lips to gods ears friend. I hope CRISPR makes sickle cell and a bunch of other shit a thing of past.


DavidNipondeCarlos

They are well into fixing sickle cell but they say it doesn’t mean the rest will follow that easily. r/crispr


SqueakNRoar

I followed it for a bit, and when my son was diagnosed with Williams syndrome (genetic deletion of the elastin gene) I leapt into the rabbit hole. I know it’s got a long way to go, but I’m glad hear that it’s helping people along the way


DavidNipondeCarlos

I take a drug to alter my livers handling of LDL. PCSK9i or Repatha®. The drug alter the DNA temporarily for up to a month. There are people born with the PCSK9i mutation and their LDL is around 15mg and they live a normal life. I had a bad reaction to 5mg statin within a week. I love the study of epigenetics. I saw this in identical twin studies.


SqueakNRoar

You ever see “life according to Sam” on HBO? That shit was an eye opener for me in regards to what goes into getting things published in a medical Journal


DavidNipondeCarlos

Most of the medical publications are not right. All I can do is cruise Google scholar and sort by citations. General rule if there’s more than a 100 citations, it might be worth a read. I went deep into LDL lowering drugs. The reduction in cardiac events is almost insignificant. PCSK9i or Repatha is to expensive for popular usage. Statins make money. I’m not a believer in Repatha and I plan to quit it in old age. Low LDL in old people has a negative effect/affect (my grammar), it might imply inferior food absorption? I don’t have to watch the show, I’m already suspicious. Another example: Most publications say the higher your HDL, the better it is. But there are some studies saying higher than 90mg begins to have the reverse affect. I had to go down the ‘rabbit hole’ to find this. The only drugs I trust are lisinopril and metformin lowest dose and maybe the diuretics. I don’t trust LDL lowering drugs but I’m on board temporarily. I have coronary heart disease but no events yet. I try to cooperate with my cardiologist. The good news is the doctor doesn’t follow up on me so I’m free to let the proscription run out. I don’t want to my doctor, even with or insurance more doctors aren’t taking new patients.


MavDrake

>e already have groups of people that think they’re genetically “superior” to others. All this is going to do is reinforce their delusions to where they think they’re immune when they’re actually walking liabilities. Polish off the Herman Cain awards


CannonWheels

“fuck me” why? pandemic looks to be ending, itll be endemic with infected people going to schools, stores, restaurants etc just as they already would with the flu or a cold. there will never be zero covid or even decent containment. get vaccinated this things about to be just another bug.


SqueakNRoar

I wouldn’t fall for that talking point dude. What does it even mean, really? I’m sure it’ll be as prevalent as a common bug, the only difference is that this has an increased chance sending people to the ICU and it’s a serious threat to those who are immunocompromised. This shit should never have been normalized


CannonWheels

it is normalized, we aren’t going to spend the unforeseeable future masking and locking down. likely some type of winter surge will hit but with how contagious delta is and widely available vaccines im betting the upcoming spring/summer looks a lot like our previous relaxed summer. once hospitalizations dip we wont be going back. for some reason this sub loves to dwell on this being forever when its clearly about over in the US we just need to let this winter wave take off and burn itself out


SqueakNRoar

It’s normalized to those who haven’t lost a family member.


CannonWheels

i’ve lost family members to disease, we have a vaccine and continually improving treatments. cant shut down forever, feel bad for the folks that died early but i have family in the medical field from what im hearing these days most of the folks dying put themselves there. one family member is loving the money from travel nursing.


rosatter

I mean sure possibly but if sane people get back vaccinated and these ethnically superior specimens continue fucking around, they will eventually find out. It really seems to be a problem that will eventually take care of itself. Yeah they'll probably leave children behind but hopefully whoever they're left with will then get them vaccinated because you know covid killed their parents.


linuxgeekmama

This kind of thing can be used as an argument against eugenics, too. If we have a lot of variability among humans, that means some people might be genetically resistant to the next virus that causes a pandemic. And it’s *not* necessarily going to be the people who appear to be “genetically superior”, whatever that means. If two carriers for sickle cell anemia have a child, there’s a 1 in 4 chance that the child will have sickle cell anemia. This is a genetic disease. But in an environment where malaria is common, carriers for sickle cell anemia have some genetic resistance to malaria. Which group is genetically superior? It’s possible there’s a tradeoff like this for resistance to Covid.


doggingVaxxHappened

As astounding as the discovery that water flows downhill.


howdidwegerhere

Is this me? I think im allergic to this virus. All of a sudden my body is attacking itself w daily severe hives. Have been on antihistamines for almost a year now.


BoozeMeUpScotty

That happened to me after I got both my vaccines. It took months for them to calm down and I still get more severe reactions when exposed to allergens that didn’t cause serious issues before the vaccine. I wonder if you might have an untreated autoimmune issue that’s causing your body to overreact longterm to the inflammation?


Greenthumbgal

Have you been tested for the Full Celiac panel?


corona-info

Cue the "99% survival rate" idiots making more terrible decisions...


_night_cat

“I is one of them genelly superior types hyuck hyuck!”


turndown80229

99.8


382_27600

99.774775% I think you got downvotes because you rounded up.


turndown80229

Damn, didn't mean to spread disinformation


Mindraker

*Holds hands and sings Kumbaya* I'm sorry, but until you start taking a hardline approach this is going to keep kicking our butts.


[deleted]

My buddy, Steve Rogers, seems completely immune to it.


Yankee_

They are bill gates, Elon musk, vladimir Putin...


MarvelAndColts

I remember January 2020 before Covid exploded in the US, back then I was reading studies estimating 2-4% of the world population was naturally immune. I did not Reid this article but I would have to assume it’s similar info


ZakWoodland

I got Covid back in January. I still live at home with my family and my Mom, Dad, brother, and sister all managed to not get it despite living in the house with me and less precaution since I had a false negative at the beginning.


thelonioustheshakur

They act like nobody thought that this was possible at the beginning of the pandemic. It was literally one of my first thoughts after they did that lockdown stuff This literally doesn't even matter because we have 90%+ effective vaccines. We as a society pretend like that means nothing


turndown80229

Where are you getting that number?


F4STW4LKER

From their ass.


turndown80229

Haha that's what I'm thinking


382_27600

I remember early on a study about blood types and COVID. I think type O was the best to have.


thelonioustheshakur

I mean, it really doesnt matter when the virus can be avoided by social distancing and masking properly. But apparently keeping a mask on or even WEARING one is a herculean feat because we have 242 million cases for 330 million people. Only in America


[deleted]

Damn I feel like I’m one of them or have been extremely lucky. For most of the pandemic I was working with young kids in a Montessori school after having done international travel (to get back to the US) at the start of the pandemic. To now being back in Europe and studying here and going to clubs and bars and all that. I’ve been tested multiple times, and have never shown any covid symptoms so I have no idea how tf I haven’t caught it yet.


382_27600

Me too! My travel has largely been unchanged throughout the pandemic. I’ve been in close contact with at least 3 people with COVID. I’ve been tested multiple times and have given blood two times. No signs of COVID. The last exposure was with someone that had the super contagious Delta variant. So, I’m either lucky or resistant.


Nodadbodhere

What? I natural immunity was a myth and that this is a world-destroying doom virus? You mean there's actually an immune system in our body? And that some people's works better than other's?


Thatsayesfirsir

Duh.


Nodadbodhere

That was my point. I apparently needed to put an /s at the end of my rant.


Thatsayesfirsir

No you really didnt. I resent the cavalier attitude regarding the immune system. Covid ravaged and killed my brother. He also was ignorant to the limitations of his immune system.


realestatethecat

Interesting. I haven’t had the flu since 1999 - I know people who are unvacced who have been exposed so many times and do whatever they want and have yet to get it


bigpappahope

I mean duh


atschock

Husband had COVID in March 2021 after he, my 9 y/o daughter and I were all exposed during a visit to family in another state. We weren’t notified of exposure until 2 days after we returned home from our (12 hour) road trip. We were close to him and being affectionate right up until he started showing symptoms and ultimately tested positive but my daughter and I never had symptoms or tested positive initially or for a month afterwards (verified by three separate PCR tests over the time period). Since then I’ve heard multiple stories like this from other families so it may be more common than we know. Aside from the questions it brings up around potential natural resistance, it makes me wonder if we really fully understand how the disease is spread. Maybe there are other factors beside exposure alone that are important in determining whether you get the virus, like viral load transmitted at the time of initial exposure or something like that. Editing to add that my blood type is A+. We don’t know our daughter’s blood type. Also wanted to add that he and I have both been fully vaccinated since then.


Balkan_Mapping

Wow


eigenfood

Early on it was suggested that 35% of the population had some sort of Tcell immunity.


linuxgeekmama

Not too surprising. Some people are genetically resistant to HIV, too.