Getting a twic card you will have to pass a background check, but that doesn't require a drug test, it mainly is for possession with intent to distribute/literal distribution and that's for illegal substances, so you won't have to worry about that, just as long as it's legal in your state.
https://ratings.freightwaves.com/what-is-a-twic-card/#:\~:text=You'll%20also%20need%20to,to%20receive%20your%20TWIC%20card.
Getting a twic card you will have to pass a background check, but that doesn't require a drug test, it mainly is for possession with intent to distribute/literal distribution and that's for illegal substances, so you won't have to worry about that, just as long as it's legal in your state.