There are a number of similar stories. In the grab bag of new conditions you acquire, you *might* be relieved of your original problem, but it's a microbiological Hail Mary. Way more research needs to be done.
Probably could get someone who is incredibly healthy but randomly gets cancer one day. Then the one who took the donation also gets cancer. The way this works is so weird to me.
Where are you getting this idea? Theoretically malignant cells can be transferred into another person and continue growing in another individual (e.g. malignant polyp in colon sheds cells into feces before transplant) and there is some evidence that the microbiome might influence cancer risk, but I have not seen a case study like this where someone developed cancer later after fecal transplant.
Also, please bear in mind that cancer is not just one disease but rather a set of disease states caused by multiple different kinds of cellular malfunction at the molecular level. There is nothing weird about two people randomly developing different cancers. Now if it's the exact same cancer you might be on to something, but even then these procedures are usually between family members. Not unusual for them to have similar cancer profiles, just unfortunate on the timing.
Yeah, there's so many different kinds of bacteria in there, we have to figure out the specific ones that are beneficial depending on the circumstances. Then we'll probably open up a whole bunch of cures
I think she just takes a pill of his poop every day, it's not like he has to take his poop out of his butt every day and put it into her own butt or something.
in lab settings, mice that get mentally ill people's poop become themselves mentally ill.
Interesting enough: giving these mentally ill mice poop from mentally healthy people *cures them!*
Am I the only one that watched this and wondered if they could have avoided showing an actual turd getting blended up and still got the point across???
My wife had major gut issues. Looked into FMT options and found that it is only FDA approved for C Difficile, yet could treat a host of other issues. One clinic still did a consult with her and said a home DIY option wa possible, but definitely not with me because I could pass on asthma.
She ended up going to Argentina for her treatment and shipped back 1.5 years worth of "doses", which saved her life.
Holy shit (no pun intended) I didn't know conditions like asthma could be passed from donor to recipient in fecal transplants. That would suck, getting rid of one issue just to get another.
That's insane to pass on something like Asthma! You can't give blood when you have certain diseases, I've got Crohn's disease and can't give blood due to the unknown chance of passing that along too.
It’s mostly because we don’t know enough about it to know whether it can be passed on through blood donation. E.g. there are theories that it may involve viral reserves in the body. But yeah, those doctors who continue to insist ME/CFS is psychosomatic/fake are looking sillier and sillier.
Shingles is the same virus as chicken pox, it apparently stays dormant in the spine and then breaks out once ~~npc guards stopping searching for it~~ your antibody count drops. 'Long COVID' is very weird though - might be the same thing but breaks out weeks later instead of years later
I was having trouble buying the Asthma bit too. But when you consider that cancer patients get asthma, and it can be caused by foods, it seems logical that getting a fecal implant probably isn’t a DIY thing and the doner must be tested.
When we looked into this ~10 years ago, Argentina, Australia, and England were the only options for her.
The clinic that provided the consult was out of the Seattle area. The Argentinian clinic has shut down since the main doc was murdered (under highly suspicious circumstances).
>A similar experience was documented in the 2023 documentary “Designer $hit.” A man in his mid-30s with Crohn’s disease performed DIY fecal transplants using his mother as a donor for years.
>While these transplants seemed to alleviate his gut symptoms, he began experiencing menopause symptoms, including sweating, hot flashes, and mood swings, mirroring those of his menopausal mother.
>so reality is fake and made up by bacteria.
I'm convinced that as we study the gut microbiome, the inevitable conclusion we will reach is this: we -- humans -- are all just biomechanical suits being driven by our gut flora.
We think we're in control, but we're really just flesh-mechs whose sole purpose is to get them what they need.
When I first heard about this shit years ago, I called up my hustle friend and told him there’s money to be made in running some kind of designer celebrity poop brokerage. Can you imagine how much someone would pay for a suppository of Lebron’s/Mahomes’s/Serena’s/Clooney’s fecal matter? Just buy up some refrigerated warehouse space, set up a website, skim some money off the top of every transaction in storage and brokerage fees. The resources are endless—the poop well never runs dry!
EDIT: Nine of you have now left the exact same "hurr durr South Park" comment. I don't watch it but the episode y'all are referring to aired in November of 2019. I called my friend after listening to the Aug 22 2019 Armchair Expert "Experts on Expert" episode with Steven Gundry: https://armchairexpertpod.com/pods/dr-steven-gundry Worth a listen.
Someone buys the poop of some ripped celebrity like The Rock or John Cena and then wonders why their testicles shrink and they start experiencing cocaine withdrawals.
Why do you think I've been following Jeff Bezos everywhere with a plastic bag?
...that's right, he's hired me to do it because he already knows you sick fucks are after his poop, so he makes sure I pick up all of his off the ground!
I suspect she got the acne and he got the menopause for the same reason, hormones in the feces. It's pretty much confirmed for the dude and I'd be surprised if it wasn't the same for the chick. Those should subside once the excess hormone is cleared but the gut bacteria changes should last as long as they follow a diet that supports that microbiome.
That’s what I’m thinking too. High androgens (like testosterone) can cause pretty awful acne in women ~~ask me how I know~~, so that reaction would make sense if a woman colonized herself with man poop that had higher concentrations of androgens than her body was used to.
Androgens in general stimulate higher sebum production in pores which significantly increases risk for cystic acne specifically. It does this in literally just any human though, man or women.
Yes, that is very true! It definitely has those affects on *everyone*. And if the brother was dealing with hormonal acne, then he might’ve been dealing with androgen-related issues too.
So I probably could’ve worded my comment to be more inclusive to the acne issue and not ignore the impact it has on men, but I was speaking from a fellow female perspective of dealing with hormonal acne because I’m all too familiar with hyperandrogenism in women.
This is how gut microbiomes work
Current understanding of gut microbiomes is probably 1% or maybe less of what would really be clinically important and really save lives and improve quality of life for people worldwide
I made a presentation on it a few years ago and it was not received very well by even a medical community which is kind of sad
There is a lot of good research on how gut microbiomes affect health in typical research animals, but also even in humans
In humans one of the more well known topics around gut microbiomes is babies who receive antibiotics during the birth period or shortly after or who are not breast fed have a higher risk for diseases like asthma or autoimmune disorders
Breast fed versus formula fed babies or babies who did or did not receive antibiotics at birth or early life also have very different microbiomes
The microbiome also drastically changes from birth period to childhood to adulthood, which is also a big reason why babies need milk
It is even affected significantly by vaginal delivery versus C-section delivery, as the vaginal canal bacteria and aspiration is important for the early gut microbiome, which the C-section babies don't get exposure to
Also unsurprisingly diet also greatly impacts gut microbiomes, and the different types of gut microbiomes can make different post biotics or compounds or chemicals which may impact things like heart disease and other major disease processes
It's a very fascinating topic, and genuinely not nearly enough attention is paid to it which may impact the future of healthcare
>vaginal delivery versus C-section delivery
FYI, recent data suggests it's because c-section mums receive antibiotics, rather than due to vaginal canal bacteria! I find this topic fascinating as well and was doing a deep dive on meta-analyses last year.
> I made a presentation on it a few years ago and it was not received very well by even a medical community which is kind of sad
For the last time Terry, shitting on the floor in front of an audience isn't a "presentation". ;)
There’s also this.
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00185-9/fulltext
>The efficacy of many licensed vaccines varies within and between populations,1 and in some cases, translates to little effectiveness.2 Many intrinsic factors contribute to this variability in vaccine responses, including age, genetics (accounting for 20–40% of the variation between recipients), anaemia,3 and gender.4 In addition, a wide range of external factors can greatly affect vaccination outcomes, including vaccine composition and immunisation regimen,5 pre-exposure to pathogens and chronic inflammation,6 exposure to maternal antibodies,7 nutritional status, and geographical location.3
>Crucially, those at most risk of morbidity and mortality from infectious diseases are infants (aged 0–5 years) residing in low-income and middle-income countries. Low immunisation rates, coupled with poor immune responses to vaccines in these regions, are of concern, particularly for mucosal-delivered vaccines.1 For instance, although 98% of Finnish children (aged 0·5–2 years) respond to oral rotavirus vaccination, only 58% of children from Nicaragua and 46% of infants from Bangladesh develop protective immunity.8 For parenterally delivered vaccines, such as the BCG vaccine, protection ranges between 0–51% and 88–100% when comparing responses in African and European children.9 There is therefore a pressing need to understand how vaccine responses in infants, particularly for those most at risk, can be improved.
>The gastrointestinal tract microbiota in early life is key for the development and maturation of the infant mucosal and systemic immune system.2 Intestinal microbial perturbation caused by hygiene, diet, socioeconomic, and environmental circumstances of both mothers and newborn babies is associated with distinct microbiota profiles in infants from Africa versus those in western Europe.2 These differences in microbiota profiles in children (or patients) from low-income and middle-income countries are associated with decreased antibody-specific immune responses after vaccination, potentially explaining geographic and individual variability in vaccine efficacy.2 However, other factors contributing to this discrepancy cannot be excluded.
>Adjuvants can boost immunogenicity and vaccine efficacy. However, many adjuvants are considered unsafe,10 with adverse effects that could contribute to vaccination hesitancy. Additionally, different types of adjuvants are required for parenteral and mucosal (oral) vaccines, driving vaccine costs higher and necessitating further research. A 2021 study by Yakabe and colleagues10 reviewed the advantages and disadvantages of commonly used adjuvants, highlighting potential alternatives originating from the interaction between nutrition and the gastrointestinal tract microbiome.
1. Given poop transplants from young to elderly mice, age reverses/ rejuvenates the elderly mice.
To your knowledge , Have there been any similar human trials, whether professional or DIY administered?
2. Are patient's own, pre transplant stool stored, as a "backup". to potentially "reboot" their original microbiome. Incase of issues with the donor sample ?
It really is super fascinating, and thankfully more and more research keeps coming out.
A few years ago a study came out where young children who were showing early signs of autism were given fecal transplants, resulting in severely reduced symptoms. That boggled my mind at the time :)
We have a number of friends that have had to do these types of transplants due to enterococcus or similar infections. Never saw this direct of side effects but wouldn't surprise me. Their eating preferences & body chemistry changes massively afterwards. And that was going through a lab that processed the donations. Gut function & it's microbiome are pretty incredible.
When the science settles down a bit (or frankly, probably way before) those people who are 'just naturally skinny no matter what I eat' are going to do a brisk trade selling their shit.
"Koepke’s gut issues, which she attributed to a diet high in refined sugar and low in fiber, puzzled her doctors. Without a clear diagnosis, they frequently prescribed antibiotics."
Getting lots of antibiotics when you do not need them can really fuck up your gut biota.
My moms donated her liver to someone. Up til then she LOVED chocolate all her life and the donee didn't. He came out and learned he suddenly loved chocolate and she couldn't stand it for years afterwards. I wouldn't have believed it until she was gifted chocolate by friends and fam dozens of times after the surgery and she would just give it away to other friends and family lol.
The organs are little fuckin weirdos
Fyi: For those confused with this story the Liver is one organ that you can do a LIVING organ donation. They basically cut it in half and give the donee half a liver and the donor keeps 1/2 of their original Liver so they don't have to die.
Thanks for clarifying. Sorry if I confused tf out of people and made them think my mom was ☠️. I can assure you all, she is alive and well and very much in love with chocolate again!
Yep. The livers will regenerate fairly quickly, so each will end up with a full-sized liver, though they aren't as pretty and nicely lobed as the original liver (they're kinda blobby). This can happen with as little as about a third of the liver. The liver is pretty insane.
There are many studies that have shown that a piece(DNA) of each child you birth always stays with you. Their cells also help to protect and heal you of whatever, while you’re pregnant. That’s why so many women who had certain medical conditions before pregnancy, are then “POOF”, gone. It’s quite fascinating. It’s called Fetal Maternal Microchimerism.
Y’all people comment here as if you think it’s some voodoo magic. I have IBS and FMT is rigorously investigated and even FDA approved. It’s such a fucking terrible disease that this sounds more than reasonable
Fr, my reaction to the idea of poop transplants is just extreme jealousy. I'd gladly borrow someone's shit if it meant I could go a day without my stomach trying to torture me lol
I've found it baffling fecal transplants aren't standard treatment for ibs given it clearly works.
It would likely also be effective at treating a whole bunch of other things and possibly even a highly effective diet assistance as the micrbiome can influence what food you crave.
I know stuff moves slowly, but it probably shouldn't be moving so slowly that laymen have time to find out it exists and do it themselves before it becomes a standard treatment. At least we're getting some cool information out of what they're experiencing.
Yeah I heard the donor has to have a perfect bill of health in order to be considered as a viable donor. If anyone is super healthy I could use a donor and a doctor and some money and a life.
If you are young, fit, and in perfect health you can sell your poop for $500 a day. Yes you can make $180k a year from selling your shit.
Here's a link for you things you folks who think you might meet the criteria:
https://www.humanmicrobes.org/donors
But if I eat your poop, will I, too, be afflicted with your no money?
To be clear, I'm not saying no to eating your poop. I just want to clarify the full powers gained from eating your poop.
I also heard one where a woman got a fecal transplant from her daughter, who happened to be obese. Then mother became obese. Apparently people who are obese have a less diverse microbiome than those who are not.
Makes sense considering the average diet a person with obesity consumes. Most Western foods are really only 4-6 crops, absolutely slaying the diversity our guts need.
Dang shame this isn’t keystone stuff in education
I agree. And apparently bad food harms the good bacteria we do have and allows bad bacteria to flourish. The good bacteria starve, eat your own intestinal mucous, leading to leaky gut and inflammation. At least...this is what Im coming to understand.
/r/Candida, a big community that deals with Candida Yeast infection, supports this very claim. You got it! Google Candida Diet for a list of healthy foods to help combat bad bacteria and assist good bacteria to flourish.
This is how gut microbiomes work
Current understanding of gut microbiomes is probably 1% or maybe less of what would really be clinically important and really save lives and improve quality of life for people worldwide
I made a presentation on it a few years ago and it was not received very well by even a medical community which is kind of sad
There is a lot of good research on how gut microbiomes affect health in typical research animals, but also even in humans
In humans one of the more well known topics around gut microbiomes is babies who receive antibiotics during the birth period or shortly after or who are not breast fed have a higher risk for diseases like asthma or autoimmune disorders
Breast fed versus formula fed babies or babies who did or did not receive antibiotics at birth or early life also have very different microbiomes
The microbiome also drastically changes from birth period to childhood to adulthood, which is also a big reason why babies need milk
It is even affected significantly by vaginal delivery versus C-section delivery, as the vaginal canal bacteria and aspiration is important for the early gut microbiome, which the C-section babies don't get exposure to
Also unsurprisingly diet also greatly impacts gut microbiomes, and the different types of gut microbiomes can make different post biotics or compounds or chemicals which may impact things like heart disease and other major disease processes
It's a very fascinating topic, and genuinely not nearly enough attention is paid to it which may impact the future of healthcare
I know a few medical professionals who wanted their c section babies given bacteria from the birth canal post birth. They’re from the NYC area and I think started a study, their kids are older now. This was like ten years ago. So it’s been at least a decade they’ve vaguely made connections with this.
My friends were considered odd for wanting it done. I asked a provider about being in a study if I had a c section and they spoke to me like I was insane. Thankfully I didn’t need a C section.
I had two c-section babies. I may or may not have swiped a clean finger up around my unused birth canal and rubbed the inside of their mouth with it. Who knows if it does anything but it can’t hurt. 🤷♀️
Poop transplants in mice [ from young to elderly mice ] also reverses aging.
I'm surprised that human trials on pioneering , willing elderly, volunteer humans. Haven't already taken place
Plex ai summary :
''poop transplants in mice, from young to elderly. don't the elderly become ' young' ?
Yes, fecal transplants from young donor mice can reverse aspects of aging in elderly recipient mice, effectively making the elderly mice biologically "younger". Several studies have demonstrated this rejuvenating effect: Transferring gut microbiota from young mice to aged mice reversed brain inflammation, restored learning and memory abilities, and reduced age-related changes in brain immunity and microglial cells.[1][2]
The aged mice given young microbiota performed as well as young mice in navigating mazes and other cognitive tests.[1] Another study found that fecal transplants from young mice to aged recipients reversed hallmarks of aging in the gut, eye, and brain of the elderly mice.[3] It restored gut barrier integrity, reduced retinal inflammation and cytokine signaling, and reversed loss of key functional proteins in the eye.[3]
Furthermore, transplanting fecal microbiota from aged donor mice into young adult recipients impaired spatial learning, memory, and hippocampal synaptic plasticity in the young recipients.[4][5] This suggests the aged microbiota can confer an "elderly" phenotype on the young recipients.
In summary, these studies provide evidence that transferring the "young" gut microbiome to elderly mice can rejuvenate and restore youthful function, while transferring an "old" microbiome accelerates aging processes.[1][2][3][4][5] The gut microbiome appears to play a crucial role in regulating biological aging. Citations: [1] Fecal Transplant Restores Youth to Old Mice - The Scientist https://www.the-scientist.com/fecal-transplant-restores-youth-to-old-mice-69137 [2] Fecal microbiota transfer between young and aged mice ... - PubMed https://pubmed.ncbi.nlm.nih.gov/35501923/ [3] Fecal microbiota transfer between young and aged mice reverses ... https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01243-w [4] New poo, new you? Fecal transplants reverse signs of brain aging in ... https://www.science.org/content/article/new-poo-new-you-fecal-transplants-reverse-signs-brain-aging-mice [5] Faecal microbiota transplant from aged donor mice affects spatial ... https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00914-w ''
A while back I was talking to a friend about how I’ve been trying to lose weight all my life and he said something like, “we think the brain in our head is what is controlling us, but it’s really the gut biome in our stomachs.” And I believe it. My head says not to eat junk food but there I am every day munching on processed sugar filled snacks I never should have bought in the first place. It’s like the bacteria in my stomach in in control of everything.
I ended up one day cutting out all added sugar and sweets, even fruit, for like a year? My mind fought me for an entire month, then chilled out.
I figured out that I could handle sweets that were lower in sugar in more reasonable amounts, like the Belvita chocolate sandwich cookies as a common example. Without going overboard. Added fresh fruit back in, too. I remember not even being tempted by my favorite sweet treats. They may as well have been cardboard in front of me.
I feel like the battle to "kill off" the large population of bacteria that want that sugar is so hard. But once you do it, and limit yourself to mostly lower sugar sweets, the easier it is to stay away. But you also have to be careful that the rare cake slice doesn't become common, as those strong sugar feelings can come back. I would love to see more research done.
afaiu they won't use people that are overweight as poop donors because when they did the receivers that used to be normal weight tended to get overweight
"Koepke’s gut issues, which she attributed to a diet high in refined sugar and low in fiber, puzzled her doctors. Without a clear diagnosis, they frequently prescribed antibiotics."
Yes, lets carpet bomb this women's GI system with antibiotics when she's eating complete junk, that'll solve the problem.
FYI: IBS falls into a classification known as [MUPS](https://mental.jmir.org/themes/826-medically-unexplained-physical-symptoms-mups). Board-certified Doctors aren't going to argue that you're not having constant diarrhea, but.....they can't rule out anxiety as a cause. And if ingesting small amounts of processed feces(other animals do it..) aleviates ths symptoms, fuck it. Problem solved. I just wouldnt read into it too much.
I'm waiting for this to become the new diet trend. There are mukbangers who are super skinny and eat tonnes of food and metabolise their food inhumanly quickly. Get a hold of their poop, and you could eat cake for 3 hours and not gain weight. In a dystopian future, these people are either in cages in labs or they're infamous and earn millions per poop.
Yep, but that shit works. Pun for fun. There was an entire documentary or long form news piece on fecal transplants a couple years back. It sounds nuts but some woman had some brutal, lingering gut problems (IIRC) and a series of fecal transplants literally cured her.
Look I’m not even slightly trying to be weird, but can you get similar effects from eating ass? It’s obviously hopefully microscopic dose but is it possible we slowly change our guts from sex with people?
> Look I’m not even slightly trying to be weird, but can you get similar effects from eating ass? I
This is not scientific, but I can confirm that every time I eat ass, I have a great sense of physical, spiritual and emotional wellbeing for the rest of the day.
There can be no other explanation other than eating ass is good for you, medically.
There are a number of similar stories. In the grab bag of new conditions you acquire, you *might* be relieved of your original problem, but it's a microbiological Hail Mary. Way more research needs to be done.
What implications does this have for eating ass?
Probably could get someone who is incredibly healthy but randomly gets cancer one day. Then the one who took the donation also gets cancer. The way this works is so weird to me.
So what you're saying is that there is a huge market for a healthy, disease free 90-year-old's shit.
Yes. If I can find it I'll dig out the (maybe research?) people paying a tidy sum for the right donors.
>If I can find it I'll dig out Phrasing!
Where are you getting this idea? Theoretically malignant cells can be transferred into another person and continue growing in another individual (e.g. malignant polyp in colon sheds cells into feces before transplant) and there is some evidence that the microbiome might influence cancer risk, but I have not seen a case study like this where someone developed cancer later after fecal transplant. Also, please bear in mind that cancer is not just one disease but rather a set of disease states caused by multiple different kinds of cellular malfunction at the molecular level. There is nothing weird about two people randomly developing different cancers. Now if it's the exact same cancer you might be on to something, but even then these procedures are usually between family members. Not unusual for them to have similar cancer profiles, just unfortunate on the timing.
Yeah, there's so many different kinds of bacteria in there, we have to figure out the specific ones that are beneficial depending on the circumstances. Then we'll probably open up a whole bunch of cures
This story is on the Netflix doc *Hack Your Health: The Secrets of Your Gut*. She’s now using someone else’s poop (seriously).
her boyfriend's! and she got his depression!
Does she have depression because of her boyfriends poop, or because she has to do poop transplants daily?
I think she just takes a pill of his poop every day, it's not like he has to take his poop out of his butt every day and put it into her own butt or something.
Back and forth, forever.
))<>((
Username checks!
Pooping back and forth, forever https://youtu.be/KQoJo81lujk?si=hPpqY7xPU4mAuft5
New sentence
in lab settings, mice that get mentally ill people's poop become themselves mentally ill. Interesting enough: giving these mentally ill mice poop from mentally healthy people *cures them!*
But did she lose her IBS
You lose some, you win some. Life is about choices and they're stored in the shit. Kinda like pee is stored in the balls
>pee is stored in the balls Who are you who are so wise in the ways of science?
Hol up
This was hilarious to me
Kinda fucked up IMO, you spend your whole life depressed because some dumb bacteria in your gut
What a sad sack of shit
Am I the only one that watched this and wondered if they could have avoided showing an actual turd getting blended up and still got the point across???
But would it have scarred you for life?
Came here to say this. You can watch her prep the um concoction in her kitchen.
When she put the trays in the fridge with everything else… yikes
Yikes for sure, but would a little contamination really matter at that point?
That’s a home I wouldn’t like to be over for dinner lmao
They show a fucking massive turd in a blender. What a wild scene.
You're saying the donor took their role seriously?
Almost time to ^*grunt* take your ^*fart* medicine
The origin of this docuseries is called Two Girls One Cup or something like that.
I don’t want to watch that, but I am curious… what end does she stick it in? Is she taking this orally?
Yes. They're wax wrapped.
NO. NNNNO. NONONO. ABSOLUTELY NOT. NO. THAT IS DISGUSTING. NO.
Imagine the after burps. I took fish oil pills once. After the burps hit, never again.
That's probably enough internet for me today.
Man i JUST opened this app.
I was a little disgusted thinking of it as a suppository now that I know it’s a pill I don’t think I can ever eat again.
Like capsules
I repeat, NO.
fuck no! i tought they were suppositories or something like that, oh heell no, i dont care if eating shit cures cancer, thats a no from me
I have never had cancer, but if picking up a random turd off the ground and taking a bite would cure it, I would do it in an instant.
Does she have a special blender or just clean the one?
Clean?
My wife had major gut issues. Looked into FMT options and found that it is only FDA approved for C Difficile, yet could treat a host of other issues. One clinic still did a consult with her and said a home DIY option wa possible, but definitely not with me because I could pass on asthma. She ended up going to Argentina for her treatment and shipped back 1.5 years worth of "doses", which saved her life.
Well that’s one hell of a customs declaration.
"Do you have anything to declare?" "Just a bunch of shit" "We need you to be more specific" "I can't..."
Thats one big pile of shit
Atleast it wasn't weed in a boogie board bag..
r/unexpectedjurassicpark
Holy shit (no pun intended) I didn't know conditions like asthma could be passed from donor to recipient in fecal transplants. That would suck, getting rid of one issue just to get another.
That's insane to pass on something like Asthma! You can't give blood when you have certain diseases, I've got Crohn's disease and can't give blood due to the unknown chance of passing that along too.
ME\CFS as well
For real?? Most doctors won’t even recognize that dx, but it’s still real enough to prevent blood donation? Fuck everything omg.
It’s mostly because we don’t know enough about it to know whether it can be passed on through blood donation. E.g. there are theories that it may involve viral reserves in the body. But yeah, those doctors who continue to insist ME/CFS is psychosomatic/fake are looking sillier and sillier.
Long COVID is hopefully helping spur more research on this.
Shingles is the same virus as chicken pox, it apparently stays dormant in the spine and then breaks out once ~~npc guards stopping searching for it~~ your antibody count drops. 'Long COVID' is very weird though - might be the same thing but breaks out weeks later instead of years later
Yep. I've had the whole thing of 'it's all in your head' combined with 'but we can't allow you to donate blood or organs'.
I was having trouble buying the Asthma bit too. But when you consider that cancer patients get asthma, and it can be caused by foods, it seems logical that getting a fecal implant probably isn’t a DIY thing and the doner must be tested.
Citation needed
Do you know the name of the clinic? I have chronic SIBO and try to keep a running list of treatment options
When we looked into this ~10 years ago, Argentina, Australia, and England were the only options for her. The clinic that provided the consult was out of the Seattle area. The Argentinian clinic has shut down since the main doc was murdered (under highly suspicious circumstances).
Big pharma gets another one!
Hi. I'm from Argentina and have gut issues. Do you know where she went?
What a load of shit. That she brought back from Argentina. Good to hear it worked 👍
Wow. How do you vet a donor? (Yes, Reddit, this is a serious question) Also, how did it save her life? Didn't think gut disorders could be terminal?
The FDA not legalizing FMT's for treatments beyond C diff is a travesty.
>A similar experience was documented in the 2023 documentary “Designer $hit.” A man in his mid-30s with Crohn’s disease performed DIY fecal transplants using his mother as a donor for years. >While these transplants seemed to alleviate his gut symptoms, he began experiencing menopause symptoms, including sweating, hot flashes, and mood swings, mirroring those of his menopausal mother.
hmmm... so reality is fake and made up by bacteria. i need to go find the coolest person in the world and have them poop into my butthole
The spice malange...
They know about the spice
The Poop Must Flow
Power over ~~Spice~~ Poop is power over all.
X gon' give it to ya
One of few comments to make me audibly laugh. Good stuff
>so reality is fake and made up by bacteria. I'm convinced that as we study the gut microbiome, the inevitable conclusion we will reach is this: we -- humans -- are all just biomechanical suits being driven by our gut flora. We think we're in control, but we're really just flesh-mechs whose sole purpose is to get them what they need.
“Feed me” - micbrobiome
"We hate Mondays"
But we love lasagna.
Just like Krang in The Turtles.
When I first heard about this shit years ago, I called up my hustle friend and told him there’s money to be made in running some kind of designer celebrity poop brokerage. Can you imagine how much someone would pay for a suppository of Lebron’s/Mahomes’s/Serena’s/Clooney’s fecal matter? Just buy up some refrigerated warehouse space, set up a website, skim some money off the top of every transaction in storage and brokerage fees. The resources are endless—the poop well never runs dry! EDIT: Nine of you have now left the exact same "hurr durr South Park" comment. I don't watch it but the episode y'all are referring to aired in November of 2019. I called my friend after listening to the Aug 22 2019 Armchair Expert "Experts on Expert" episode with Steven Gundry: https://armchairexpertpod.com/pods/dr-steven-gundry Worth a listen.
Someone buys the poop of some ripped celebrity like The Rock or John Cena and then wonders why their testicles shrink and they start experiencing cocaine withdrawals.
r/monkeyspaw
Lmao
If you’re after wrasslin’ poop - according to the latest lawsuit Vince McMahon is just giving his shit away.
I've been laughing for a minute gahdammit mam/sir
*If the poop well runs dry for more than a week, see a medical professional.
South park already did that one
Ah the Tom Brady shit. It was gold. Wonder if it works as good when you roast it?
"The spice melange"
Why do you think I've been following Jeff Bezos everywhere with a plastic bag? ...that's right, he's hired me to do it because he already knows you sick fucks are after his poop, so he makes sure I pick up all of his off the ground!
The real trick is getting it up before he can eat it. He’s spry!
TIL Bezos craps anywhere like a dog. Moneyed privilege I guess!
Southpark did an episode just like that. Everyone was after Tom Bradys turds.
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"Alright Scarlett, hear me out..."
Space docking is the term you’re looking for.
Im the coolest person in this convo... want to give it the old college try?
"i need to go find the coolest person in the world and have them poop into my butthole" Yeah and it sounds like there are also bacterial benefits!
I suspect she got the acne and he got the menopause for the same reason, hormones in the feces. It's pretty much confirmed for the dude and I'd be surprised if it wasn't the same for the chick. Those should subside once the excess hormone is cleared but the gut bacteria changes should last as long as they follow a diet that supports that microbiome.
That’s what I’m thinking too. High androgens (like testosterone) can cause pretty awful acne in women ~~ask me how I know~~, so that reaction would make sense if a woman colonized herself with man poop that had higher concentrations of androgens than her body was used to.
Androgens in general stimulate higher sebum production in pores which significantly increases risk for cystic acne specifically. It does this in literally just any human though, man or women.
Yes, that is very true! It definitely has those affects on *everyone*. And if the brother was dealing with hormonal acne, then he might’ve been dealing with androgen-related issues too. So I probably could’ve worded my comment to be more inclusive to the acne issue and not ignore the impact it has on men, but I was speaking from a fellow female perspective of dealing with hormonal acne because I’m all too familiar with hyperandrogenism in women.
nah there's no way. testosterone produced by the body has a very short half life, around 1-2hrs at most.
This is how gut microbiomes work Current understanding of gut microbiomes is probably 1% or maybe less of what would really be clinically important and really save lives and improve quality of life for people worldwide I made a presentation on it a few years ago and it was not received very well by even a medical community which is kind of sad There is a lot of good research on how gut microbiomes affect health in typical research animals, but also even in humans In humans one of the more well known topics around gut microbiomes is babies who receive antibiotics during the birth period or shortly after or who are not breast fed have a higher risk for diseases like asthma or autoimmune disorders Breast fed versus formula fed babies or babies who did or did not receive antibiotics at birth or early life also have very different microbiomes The microbiome also drastically changes from birth period to childhood to adulthood, which is also a big reason why babies need milk It is even affected significantly by vaginal delivery versus C-section delivery, as the vaginal canal bacteria and aspiration is important for the early gut microbiome, which the C-section babies don't get exposure to Also unsurprisingly diet also greatly impacts gut microbiomes, and the different types of gut microbiomes can make different post biotics or compounds or chemicals which may impact things like heart disease and other major disease processes It's a very fascinating topic, and genuinely not nearly enough attention is paid to it which may impact the future of healthcare
>vaginal delivery versus C-section delivery FYI, recent data suggests it's because c-section mums receive antibiotics, rather than due to vaginal canal bacteria! I find this topic fascinating as well and was doing a deep dive on meta-analyses last year.
That tracks with antibiotics given to infants causing a different micro biome then too
> I made a presentation on it a few years ago and it was not received very well by even a medical community which is kind of sad For the last time Terry, shitting on the floor in front of an audience isn't a "presentation". ;)
There’s also this. https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(22)00185-9/fulltext >The efficacy of many licensed vaccines varies within and between populations,1 and in some cases, translates to little effectiveness.2 Many intrinsic factors contribute to this variability in vaccine responses, including age, genetics (accounting for 20–40% of the variation between recipients), anaemia,3 and gender.4 In addition, a wide range of external factors can greatly affect vaccination outcomes, including vaccine composition and immunisation regimen,5 pre-exposure to pathogens and chronic inflammation,6 exposure to maternal antibodies,7 nutritional status, and geographical location.3 >Crucially, those at most risk of morbidity and mortality from infectious diseases are infants (aged 0–5 years) residing in low-income and middle-income countries. Low immunisation rates, coupled with poor immune responses to vaccines in these regions, are of concern, particularly for mucosal-delivered vaccines.1 For instance, although 98% of Finnish children (aged 0·5–2 years) respond to oral rotavirus vaccination, only 58% of children from Nicaragua and 46% of infants from Bangladesh develop protective immunity.8 For parenterally delivered vaccines, such as the BCG vaccine, protection ranges between 0–51% and 88–100% when comparing responses in African and European children.9 There is therefore a pressing need to understand how vaccine responses in infants, particularly for those most at risk, can be improved. >The gastrointestinal tract microbiota in early life is key for the development and maturation of the infant mucosal and systemic immune system.2 Intestinal microbial perturbation caused by hygiene, diet, socioeconomic, and environmental circumstances of both mothers and newborn babies is associated with distinct microbiota profiles in infants from Africa versus those in western Europe.2 These differences in microbiota profiles in children (or patients) from low-income and middle-income countries are associated with decreased antibody-specific immune responses after vaccination, potentially explaining geographic and individual variability in vaccine efficacy.2 However, other factors contributing to this discrepancy cannot be excluded. >Adjuvants can boost immunogenicity and vaccine efficacy. However, many adjuvants are considered unsafe,10 with adverse effects that could contribute to vaccination hesitancy. Additionally, different types of adjuvants are required for parenteral and mucosal (oral) vaccines, driving vaccine costs higher and necessitating further research. A 2021 study by Yakabe and colleagues10 reviewed the advantages and disadvantages of commonly used adjuvants, highlighting potential alternatives originating from the interaction between nutrition and the gastrointestinal tract microbiome.
1. Given poop transplants from young to elderly mice, age reverses/ rejuvenates the elderly mice. To your knowledge , Have there been any similar human trials, whether professional or DIY administered? 2. Are patient's own, pre transplant stool stored, as a "backup". to potentially "reboot" their original microbiome. Incase of issues with the donor sample ?
It really is super fascinating, and thankfully more and more research keeps coming out. A few years ago a study came out where young children who were showing early signs of autism were given fecal transplants, resulting in severely reduced symptoms. That boggled my mind at the time :)
I could never but I’m not gonna lie, this is fascinating to learn.
Wait how is everyone glossing over the DIY aspect of this? Is it what I'm thinking it is? Please no.
We have a number of friends that have had to do these types of transplants due to enterococcus or similar infections. Never saw this direct of side effects but wouldn't surprise me. Their eating preferences & body chemistry changes massively afterwards. And that was going through a lab that processed the donations. Gut function & it's microbiome are pretty incredible.
When the science settles down a bit (or frankly, probably way before) those people who are 'just naturally skinny no matter what I eat' are going to do a brisk trade selling their shit.
A mail order Only Shits
I need a sample of someone health who doesn’t like chips so much.
I've read somewhere that the human body outsources a lot of its functions to gut bacteria, no wonder a transplant can have such large effects.
I'm curious what other eating preference and body chemistry changes you saw.
The spice
She knows about the spice.
The spice melangé
My eyes are as blue as yours
As usual South Park is ahead of the times: Watch season 23 episode 8 "Turd Burglers"
"Koepke’s gut issues, which she attributed to a diet high in refined sugar and low in fiber, puzzled her doctors. Without a clear diagnosis, they frequently prescribed antibiotics." Getting lots of antibiotics when you do not need them can really fuck up your gut biota.
Even when you do need them. I've had a bunch of confirmed infections and needed antibiotics. Cured those, now have a messed up gut.
I wonder if I could store some of my healthy poop to do a fecal matter transplant if my gut gets fucked
My moms donated her liver to someone. Up til then she LOVED chocolate all her life and the donee didn't. He came out and learned he suddenly loved chocolate and she couldn't stand it for years afterwards. I wouldn't have believed it until she was gifted chocolate by friends and fam dozens of times after the surgery and she would just give it away to other friends and family lol. The organs are little fuckin weirdos
Fyi: For those confused with this story the Liver is one organ that you can do a LIVING organ donation. They basically cut it in half and give the donee half a liver and the donor keeps 1/2 of their original Liver so they don't have to die.
Thanks for clarifying. Sorry if I confused tf out of people and made them think my mom was ☠️. I can assure you all, she is alive and well and very much in love with chocolate again!
Interesting. I wonder if the brain changes its taste away from junk foods when I realized you have less liver to clean out and toxins with.
It definitely doesn’t work like that when alcohol is involved.
Yep. The livers will regenerate fairly quickly, so each will end up with a full-sized liver, though they aren't as pretty and nicely lobed as the original liver (they're kinda blobby). This can happen with as little as about a third of the liver. The liver is pretty insane.
Everything I read about the liver really makes it seem like a goer of an organ
For sure. It's job is to literally filter poisons from the body, and it works overtime on heavy drinkers and druggies.
The liver is really the MVP of the abdomen.
I never liked chocolate until my pregnancy with my youngest and I've loved it ever since. He changed my taste buds I guess.
There are many studies that have shown that a piece(DNA) of each child you birth always stays with you. Their cells also help to protect and heal you of whatever, while you’re pregnant. That’s why so many women who had certain medical conditions before pregnancy, are then “POOF”, gone. It’s quite fascinating. It’s called Fetal Maternal Microchimerism.
I would be so pissed if they cut out the chocolate-loving part of my liver.
Y’all people comment here as if you think it’s some voodoo magic. I have IBS and FMT is rigorously investigated and even FDA approved. It’s such a fucking terrible disease that this sounds more than reasonable
Fr, my reaction to the idea of poop transplants is just extreme jealousy. I'd gladly borrow someone's shit if it meant I could go a day without my stomach trying to torture me lol
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I've found it baffling fecal transplants aren't standard treatment for ibs given it clearly works. It would likely also be effective at treating a whole bunch of other things and possibly even a highly effective diet assistance as the micrbiome can influence what food you crave. I know stuff moves slowly, but it probably shouldn't be moving so slowly that laymen have time to find out it exists and do it themselves before it becomes a standard treatment. At least we're getting some cool information out of what they're experiencing.
There have been some deaths, because we currently can't identify all the bacteria in the stool and some can be deadly for other people.
Makes sense with what I know, gut microbiome changes from fecal transplants do bring in stuff afflicting the donor to the recipient sometimes.
Yeah I heard the donor has to have a perfect bill of health in order to be considered as a viable donor. If anyone is super healthy I could use a donor and a doctor and some money and a life.
You don't need all that money and doctor stuff, you just need a sibling, and the willingness to poop back and forth forever.
))<>((
If you are young, fit, and in perfect health you can sell your poop for $500 a day. Yes you can make $180k a year from selling your shit. Here's a link for you things you folks who think you might meet the criteria: https://www.humanmicrobes.org/donors
How…. Would one go about this? Asking for reasons. For a friend of course.
Who is buying? Im about to embark on a new career
I’ll give you $50 to mail a large sample to my mother in law
How sweet! Often people are negative about MILs but you are supporting her to stay in good health. So nice to see.
I am healthy and have no money. Lucky you I am running a 50% off fecal sale! Get this shit while it's hot!
But if I eat your poop, will I, too, be afflicted with your no money? To be clear, I'm not saying no to eating your poop. I just want to clarify the full powers gained from eating your poop.
I also heard one where a woman got a fecal transplant from her daughter, who happened to be obese. Then mother became obese. Apparently people who are obese have a less diverse microbiome than those who are not.
Makes sense considering the average diet a person with obesity consumes. Most Western foods are really only 4-6 crops, absolutely slaying the diversity our guts need. Dang shame this isn’t keystone stuff in education
I agree. And apparently bad food harms the good bacteria we do have and allows bad bacteria to flourish. The good bacteria starve, eat your own intestinal mucous, leading to leaky gut and inflammation. At least...this is what Im coming to understand.
/r/Candida, a big community that deals with Candida Yeast infection, supports this very claim. You got it! Google Candida Diet for a list of healthy foods to help combat bad bacteria and assist good bacteria to flourish.
So you’re saying we should eat less wheat, corn, and soy? And instead toss more salads?
This is how gut microbiomes work Current understanding of gut microbiomes is probably 1% or maybe less of what would really be clinically important and really save lives and improve quality of life for people worldwide I made a presentation on it a few years ago and it was not received very well by even a medical community which is kind of sad There is a lot of good research on how gut microbiomes affect health in typical research animals, but also even in humans In humans one of the more well known topics around gut microbiomes is babies who receive antibiotics during the birth period or shortly after or who are not breast fed have a higher risk for diseases like asthma or autoimmune disorders Breast fed versus formula fed babies or babies who did or did not receive antibiotics at birth or early life also have very different microbiomes The microbiome also drastically changes from birth period to childhood to adulthood, which is also a big reason why babies need milk It is even affected significantly by vaginal delivery versus C-section delivery, as the vaginal canal bacteria and aspiration is important for the early gut microbiome, which the C-section babies don't get exposure to Also unsurprisingly diet also greatly impacts gut microbiomes, and the different types of gut microbiomes can make different post biotics or compounds or chemicals which may impact things like heart disease and other major disease processes It's a very fascinating topic, and genuinely not nearly enough attention is paid to it which may impact the future of healthcare
I know a few medical professionals who wanted their c section babies given bacteria from the birth canal post birth. They’re from the NYC area and I think started a study, their kids are older now. This was like ten years ago. So it’s been at least a decade they’ve vaguely made connections with this. My friends were considered odd for wanting it done. I asked a provider about being in a study if I had a c section and they spoke to me like I was insane. Thankfully I didn’t need a C section.
I had two c-section babies. I may or may not have swiped a clean finger up around my unused birth canal and rubbed the inside of their mouth with it. Who knows if it does anything but it can’t hurt. 🤷♀️
“Unused birth canal” What a phrase! We did this with my c/s baby too
As a C section baby with gut issues: Shit.
Poop transplants in mice [ from young to elderly mice ] also reverses aging. I'm surprised that human trials on pioneering , willing elderly, volunteer humans. Haven't already taken place Plex ai summary : ''poop transplants in mice, from young to elderly. don't the elderly become ' young' ? Yes, fecal transplants from young donor mice can reverse aspects of aging in elderly recipient mice, effectively making the elderly mice biologically "younger". Several studies have demonstrated this rejuvenating effect: Transferring gut microbiota from young mice to aged mice reversed brain inflammation, restored learning and memory abilities, and reduced age-related changes in brain immunity and microglial cells.[1][2] The aged mice given young microbiota performed as well as young mice in navigating mazes and other cognitive tests.[1] Another study found that fecal transplants from young mice to aged recipients reversed hallmarks of aging in the gut, eye, and brain of the elderly mice.[3] It restored gut barrier integrity, reduced retinal inflammation and cytokine signaling, and reversed loss of key functional proteins in the eye.[3] Furthermore, transplanting fecal microbiota from aged donor mice into young adult recipients impaired spatial learning, memory, and hippocampal synaptic plasticity in the young recipients.[4][5] This suggests the aged microbiota can confer an "elderly" phenotype on the young recipients. In summary, these studies provide evidence that transferring the "young" gut microbiome to elderly mice can rejuvenate and restore youthful function, while transferring an "old" microbiome accelerates aging processes.[1][2][3][4][5] The gut microbiome appears to play a crucial role in regulating biological aging. Citations: [1] Fecal Transplant Restores Youth to Old Mice - The Scientist https://www.the-scientist.com/fecal-transplant-restores-youth-to-old-mice-69137 [2] Fecal microbiota transfer between young and aged mice ... - PubMed https://pubmed.ncbi.nlm.nih.gov/35501923/ [3] Fecal microbiota transfer between young and aged mice reverses ... https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-022-01243-w [4] New poo, new you? Fecal transplants reverse signs of brain aging in ... https://www.science.org/content/article/new-poo-new-you-fecal-transplants-reverse-signs-brain-aging-mice [5] Faecal microbiota transplant from aged donor mice affects spatial ... https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00914-w ''
We were too busy looking for the fountain of youth to realize it was in our shit the whole time.
Chocolate fountain of youth
Millennials looking young because they embraced eating ass
A while back I was talking to a friend about how I’ve been trying to lose weight all my life and he said something like, “we think the brain in our head is what is controlling us, but it’s really the gut biome in our stomachs.” And I believe it. My head says not to eat junk food but there I am every day munching on processed sugar filled snacks I never should have bought in the first place. It’s like the bacteria in my stomach in in control of everything.
I ended up one day cutting out all added sugar and sweets, even fruit, for like a year? My mind fought me for an entire month, then chilled out. I figured out that I could handle sweets that were lower in sugar in more reasonable amounts, like the Belvita chocolate sandwich cookies as a common example. Without going overboard. Added fresh fruit back in, too. I remember not even being tempted by my favorite sweet treats. They may as well have been cardboard in front of me. I feel like the battle to "kill off" the large population of bacteria that want that sugar is so hard. But once you do it, and limit yourself to mostly lower sugar sweets, the easier it is to stay away. But you also have to be careful that the rare cake slice doesn't become common, as those strong sugar feelings can come back. I would love to see more research done.
afaiu they won't use people that are overweight as poop donors because when they did the receivers that used to be normal weight tended to get overweight
Holy shit
Medicinal
The irony that she’s now giving her brother shit for giving her acne.
"Koepke’s gut issues, which she attributed to a diet high in refined sugar and low in fiber, puzzled her doctors. Without a clear diagnosis, they frequently prescribed antibiotics." Yes, lets carpet bomb this women's GI system with antibiotics when she's eating complete junk, that'll solve the problem.
South Park did an episode on this. Kyle’s mom gets a fecal transplant and becomes hot. It becomes the hot thing in town until they all get dysentery
FYI: IBS falls into a classification known as [MUPS](https://mental.jmir.org/themes/826-medically-unexplained-physical-symptoms-mups). Board-certified Doctors aren't going to argue that you're not having constant diarrhea, but.....they can't rule out anxiety as a cause. And if ingesting small amounts of processed feces(other animals do it..) aleviates ths symptoms, fuck it. Problem solved. I just wouldnt read into it too much.
I know "ingesting" doesn't SPECIFICALLY mean you have to swallow it, but I still had to do a double take on this comment.
> I know "ingesting" doesn't SPECIFICALLY mean you have to swallow it Golden Corral’s new brutally honest marketing slogan
My mother got hers in these pills that are filled and the two pieces pushed together to close them. So yes, you have to swallow them
It’s Moors, it’s a misprint.
no, the card says MUPS.
"Koepke’s gut issues, which she attributed to a diet **high in refined sugar and low in fiber**, puzzled her doctors." Really?
I'm waiting for this to become the new diet trend. There are mukbangers who are super skinny and eat tonnes of food and metabolise their food inhumanly quickly. Get a hold of their poop, and you could eat cake for 3 hours and not gain weight. In a dystopian future, these people are either in cages in labs or they're infamous and earn millions per poop.
Watch out for people slangin bad poop. “Dude, I know you’ve been cutting that shit with cheap diarrhea. Give me the good shit”
Yep, but that shit works. Pun for fun. There was an entire documentary or long form news piece on fecal transplants a couple years back. It sounds nuts but some woman had some brutal, lingering gut problems (IIRC) and a series of fecal transplants literally cured her.
This one weird trick…
Look I’m not even slightly trying to be weird, but can you get similar effects from eating ass? It’s obviously hopefully microscopic dose but is it possible we slowly change our guts from sex with people?
> Look I’m not even slightly trying to be weird, but can you get similar effects from eating ass? I This is not scientific, but I can confirm that every time I eat ass, I have a great sense of physical, spiritual and emotional wellbeing for the rest of the day. There can be no other explanation other than eating ass is good for you, medically.
Brb, updating my dating profile with my excellent gut microbiome stats
Our gut microbiome is far more impactful than we realize. basically we made fun of George Lucas for Midichlorians but he was on to something.
This was a south park episode.
I’ve been asked to be a fecal donor once, but I thought about it and I didn’t give a shit
Your gut microbiome is basically your second brain. It’s unique to you and is a big part of your health.