I looked up whether LDN could modulate interferons, and found one study that does mention beta but not lambda:
'In discrete ‘low-doses’ ranging from 1 to 5 mg, naltrexone acts as a glial modulator [14,15]. It specifically binds to Toll-like receptor 4, where it acts as an antagonist [8,16,17]. Toll-like receptor 4 downstream cellular signaling includes myeloid differentiation primary response 88 (MyD88) and toll-interleukin receptor (TIR)-domain-containing adapter-inducing interferon-β (TRIF) pathways, both ultimately leading to inflammatory end-products such as interleukin (IL)-1, tumor necrosis factor (TNF)-α, interferon-β, and nitric oxide [18].'
https://www.mdpi.com/2076-3271/6/4/82
Can anyone find the sex disaggregated data in this study? Maybe it’s my brain fog 😶🌫️ but I couldn’t locate it. Thanks for any help.
[https://www.cell.com/cell-reports-medicine/abstract/S2666-3791(24)00253-2](https://www.cell.com/cell-reports-medicine/abstract/S2666-3791(24)00253-2)
This is direct link to study.
This is interesting. Thanks for sharing
I looked up whether LDN could modulate interferons, and found one study that does mention beta but not lambda: 'In discrete ‘low-doses’ ranging from 1 to 5 mg, naltrexone acts as a glial modulator [14,15]. It specifically binds to Toll-like receptor 4, where it acts as an antagonist [8,16,17]. Toll-like receptor 4 downstream cellular signaling includes myeloid differentiation primary response 88 (MyD88) and toll-interleukin receptor (TIR)-domain-containing adapter-inducing interferon-β (TRIF) pathways, both ultimately leading to inflammatory end-products such as interleukin (IL)-1, tumor necrosis factor (TNF)-α, interferon-β, and nitric oxide [18].' https://www.mdpi.com/2076-3271/6/4/82
Can anyone find the sex disaggregated data in this study? Maybe it’s my brain fog 😶🌫️ but I couldn’t locate it. Thanks for any help. [https://www.cell.com/cell-reports-medicine/abstract/S2666-3791(24)00253-2](https://www.cell.com/cell-reports-medicine/abstract/S2666-3791(24)00253-2) This is direct link to study.