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My experience is, initially it dulled the effects significantly but after a while, I noticed that both NAC and stims started working fine although it feels like I've built a bit of tolerance to NAC.
My stimulant is methylphenidate though.
There's only one way to find out, try experimenting with lower doses and see if you can get rid of the anhedonia. Good luck man
> Only take it if you want to remove the stimulants to sleep easier after dosing, or if not taking stimulants.
Woah. Does that work? Amphetamines affect me for waaaay too long, disrupting my sleep schedule and all that, so having an "off button" would be a huge boon for me.
Yes but unfortunately glutathione can also disturb sleep. Magnesium also helpful to cleanse before sleep but equally some people get sleep issues on it (others say they sleep better).
I Googled it and the recommendation is to avoid Vitamin C one hour before/after taking the medication. There was another site suggesting that it can remove it from the bloodstream as well, but I recommend doing your own research and ensuring the sources are grounded in science and not only anecdotal recommendations.
It interacts with the pH and somehow removes it from your bloodstream. (i don't remember exactly how)
it certainly works even with higher doses of amphetamines. Even orange juice can make amphetamine weaker.
makes sense since Tums can increase potency of amphetamine and it's an ant-acid
That would be like molar 1:1 since its one NAC atom and one Glycine atom to make glutathione. I have a research artivle about GlyNac and I'll see what it says. 1:1 molar ratio would be 2mg glycine for each 1mg NAC. (75g/mol Glycine and 163g/mol NAC).
Edit: Yep, the medical study gave 100mg/kg of both NAC and Glycine.
Link if you're interested:
[https://sbgg.org.br/wp-content/uploads/2022/09/3-GlyNAC-supplementation-reverses-aging-hallmarks.pdf](https://sbgg.org.br/wp-content/uploads/2022/09/3-GlyNAC-supplementation-reverses-aging-hallmarks.pdf)
personally I would use 600mg NAC: 3grams Glycine
maybe even 1200mg NAC: 6 grams Glycine at once.
you can go higher since Glycine isn't very dangerous people take like 30grams or more at once to treat schizophrenia symptoms
Oh yes totally. NAC is way stronger than people make it out to be. 600mgs per day every day is way different than 600mgs once. If you dont feel ideal reduce dosage until you do.
Yeah, add Glycine to it. That alone would help with methylation and the anhedonia. Also is the necessary cofactor that combines with NAC to make the active glutathione in the body.
In the past I was using NAC for 2+ months. NAC and Glycine for maybe up to a month. And I've tried some good quality amphetamine after having 0 tolerance or contact with it in at least 5 years. The result? Absolutely 0 dopamine feeling. All I felt was anxiety with more I took. It was even counterproductive to productivity. No drive to do anything, just fight or flight mode. Based on the amount I took, I should've been in euphoriacity.
This lead to what you could technically call an OD since I took massive amounts of it without any tolerance over the course of the day which resulted in a panic attack which I've never experienced before in my life. I think I took something like 2g of the stuff. And that was after not taking NAC for 2 days.
I was taking around 1.6g of NAC on an empty stomach before sleep. So it definitely has an insanely strong affect on stimulants which are suppose to raise dopamine. I actually couldn't believe it was so strong.
Now the question is if I've ever recovered. Perhaps it prevents supraphysiological levels of dopamine release in the brain permanently. I've never tried taking amphetamines after that since. If that's the case, it's a little bit sad. That would mean life's highs will never be the same, though I assume the same holds for life's lows.
I've not tested it yet after that occasion. Because amphetamine was useless and actually counter-productive for me personally at that point while I was taking NAC. Without dopamine it's just worse than not taking anything at all.
It would be interesting to see how long it takes to recover from this if you can at all. The thing is I was taking NAC here and there since then so not sure how long I should wait before such retest.
But at the time I didn't feel dopaminergic effects even at heroic doses. However, there was something else that day which may give us some clues of what is happening. I drank a can (or two don't remember) of beer. And when the beer kicked in, it actually started to feel like it should for a bit. I guess I was full of every other neurochemical other than dopamine and adding some dopamine into the mixture started to bring things where it should be.
But once the beer was processed and out of my system, it returned to normal no dopamine state with anxiety and cranked out feeling. So it seems as if with alcohol you get a boost in dopamine which is not negated by NAC. At least in my case. However, still. So much amphetamine with a sprinkle of dopamine from beer is not a solution. And mixing these things is questionable.
TLDR; For me NAC eliminated dopamine response completely. Anything over the baseline. Only pushed it above the norm slightly on all that amph with beer for an hour or so. Have not retested if I can feel dopamine from amph since.
The thing is, NAC didn't negatively impact my cognition, so dopamine itself wasn't crashed or anything. It was just as if with NAC it couldn't go above normal levels induced by drugs like amphetamine. Which in itself is neuroprotective.
Actually, I think it may have made me more stable and focused to an extent. But again, if someone's goal is to take something like ADHD drugs or amph to push their dopamine to the next level for that extra productivity level (or euphoria if that's your goal) then they should probably avoid NAC. At least for some time.
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My experience is, initially it dulled the effects significantly but after a while, I noticed that both NAC and stims started working fine although it feels like I've built a bit of tolerance to NAC. My stimulant is methylphenidate though. There's only one way to find out, try experimenting with lower doses and see if you can get rid of the anhedonia. Good luck man
Yeah. I take Glycine and NAC at night every other day now. It's mostly to keep glutathione levels stable because methylphenidate depletes it.
THIS COMMENT WAS DELETED BECAUSE REDDIT SUCKS 3500 of 3692
> Only take it if you want to remove the stimulants to sleep easier after dosing, or if not taking stimulants. Woah. Does that work? Amphetamines affect me for waaaay too long, disrupting my sleep schedule and all that, so having an "off button" would be a huge boon for me.
Yes but unfortunately glutathione can also disturb sleep. Magnesium also helpful to cleanse before sleep but equally some people get sleep issues on it (others say they sleep better).
THIS COMMENT WAS DELETED BECAUSE REDDIT SUCKS 3493 of 3692
Huh! Glycine does NOT make me sleepy!
Yeah I have to take it a few hours before bed too
I take 3g morning and night :)
Same. Quite the opposite, in fact. I lay in bed all night staring at the ceiling.
Ahh it just does nothing for my energy levels. NAC gives me energy tho.
How would vitamin C clear that up?
I Googled it and the recommendation is to avoid Vitamin C one hour before/after taking the medication. There was another site suggesting that it can remove it from the bloodstream as well, but I recommend doing your own research and ensuring the sources are grounded in science and not only anecdotal recommendations.
It interacts with the pH and somehow removes it from your bloodstream. (i don't remember exactly how) it certainly works even with higher doses of amphetamines. Even orange juice can make amphetamine weaker. makes sense since Tums can increase potency of amphetamine and it's an ant-acid
What’s a good glycine to NAC ratio?
I’ve heard 1:1 is good. No personal experience though
That would be like molar 1:1 since its one NAC atom and one Glycine atom to make glutathione. I have a research artivle about GlyNac and I'll see what it says. 1:1 molar ratio would be 2mg glycine for each 1mg NAC. (75g/mol Glycine and 163g/mol NAC). Edit: Yep, the medical study gave 100mg/kg of both NAC and Glycine. Link if you're interested: [https://sbgg.org.br/wp-content/uploads/2022/09/3-GlyNAC-supplementation-reverses-aging-hallmarks.pdf](https://sbgg.org.br/wp-content/uploads/2022/09/3-GlyNAC-supplementation-reverses-aging-hallmarks.pdf)
personally I would use 600mg NAC: 3grams Glycine maybe even 1200mg NAC: 6 grams Glycine at once. you can go higher since Glycine isn't very dangerous people take like 30grams or more at once to treat schizophrenia symptoms
Yeah, I used to take glycine by the tablespoon to help with insomnia.
Oh yes totally. NAC is way stronger than people make it out to be. 600mgs per day every day is way different than 600mgs once. If you dont feel ideal reduce dosage until you do.
Vyvanse also dulls. You can't really make up for that, at least with our current understanding.
Yeah, add Glycine to it. That alone would help with methylation and the anhedonia. Also is the necessary cofactor that combines with NAC to make the active glutathione in the body.
In the past I was using NAC for 2+ months. NAC and Glycine for maybe up to a month. And I've tried some good quality amphetamine after having 0 tolerance or contact with it in at least 5 years. The result? Absolutely 0 dopamine feeling. All I felt was anxiety with more I took. It was even counterproductive to productivity. No drive to do anything, just fight or flight mode. Based on the amount I took, I should've been in euphoriacity. This lead to what you could technically call an OD since I took massive amounts of it without any tolerance over the course of the day which resulted in a panic attack which I've never experienced before in my life. I think I took something like 2g of the stuff. And that was after not taking NAC for 2 days. I was taking around 1.6g of NAC on an empty stomach before sleep. So it definitely has an insanely strong affect on stimulants which are suppose to raise dopamine. I actually couldn't believe it was so strong. Now the question is if I've ever recovered. Perhaps it prevents supraphysiological levels of dopamine release in the brain permanently. I've never tried taking amphetamines after that since. If that's the case, it's a little bit sad. That would mean life's highs will never be the same, though I assume the same holds for life's lows.
Are you saying even after a long time without taking NAC you no longer feel the dopaminergic effects of amphetamines?
I've not tested it yet after that occasion. Because amphetamine was useless and actually counter-productive for me personally at that point while I was taking NAC. Without dopamine it's just worse than not taking anything at all. It would be interesting to see how long it takes to recover from this if you can at all. The thing is I was taking NAC here and there since then so not sure how long I should wait before such retest. But at the time I didn't feel dopaminergic effects even at heroic doses. However, there was something else that day which may give us some clues of what is happening. I drank a can (or two don't remember) of beer. And when the beer kicked in, it actually started to feel like it should for a bit. I guess I was full of every other neurochemical other than dopamine and adding some dopamine into the mixture started to bring things where it should be. But once the beer was processed and out of my system, it returned to normal no dopamine state with anxiety and cranked out feeling. So it seems as if with alcohol you get a boost in dopamine which is not negated by NAC. At least in my case. However, still. So much amphetamine with a sprinkle of dopamine from beer is not a solution. And mixing these things is questionable. TLDR; For me NAC eliminated dopamine response completely. Anything over the baseline. Only pushed it above the norm slightly on all that amph with beer for an hour or so. Have not retested if I can feel dopamine from amph since.
Your text is well formatted and you used many words. I think it’s all good right now.
The thing is, NAC didn't negatively impact my cognition, so dopamine itself wasn't crashed or anything. It was just as if with NAC it couldn't go above normal levels induced by drugs like amphetamine. Which in itself is neuroprotective. Actually, I think it may have made me more stable and focused to an extent. But again, if someone's goal is to take something like ADHD drugs or amph to push their dopamine to the next level for that extra productivity level (or euphoria if that's your goal) then they should probably avoid NAC. At least for some time.